Results 141 to 150 of about 29,949 (269)
The Journal of Physiology, EarlyView.Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga +8 more
wiley +1 more source
Molecular MedicineThe aberrant acetylation of mitochondrial proteins is involved in the pathogenesis of multiple diseases including neurodegenerative diseases and cerebral ischemic injury.
Jiejie Zhang +8 more
doaj +1 more source
Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics [PDF]
, 2018 Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available ...
Anderton, Ryan S +4 more
core +1 more source
The role of Drp1 in adult skeletal muscle physiology [PDF]
The Journal of Physiology, 2020 Valentin Dablainville +1 more
openaire +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Dose‐dependent effects of radiation on cardiac electrophysiology and arrhythmia susceptibility. At low radiation doses (left), increased reactive oxygen species (ROS) initiate an ROS–Ca2+ positive feedback loop involving calcium/calmodulin‐dependent protein kinase II (CaMKII) activation, enhanced L‐type Ca2+ current (ICaL ...
Hannah M. Zukowski, Colleen E. Clancy
wiley +1 more source
SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia
The Journal of Physiology, EarlyView.Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu +5 more
wiley +1 more source
Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.The graphical abstract follows a top‐to‐bottom flow: stressors → ER–mitochondria crosstalk → ophthalmic diseases. The central panel highlights three core mitochondria‐associated membrane function axes, color‐coded as follows: light yellow for Ca2+ homeostasis, light blue for mitochondrial dynamics, and light red for mitophagy.
Luyang Jiang +5 more
wiley +1 more source
Journal of Experimental PharmacologyTahir Mehmood,1,2 Qandeel Nasir,2 Iqra Younis,2 Chatchai Muanprasat1 1Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangpla, Bangplee, Samut Prakarn, Thailand; 2Department of Biological Sciences ...
Mehmood T +3 more
doaj
Heme Metabolism‐Derived Carbon Monoxide Regulates Skeletal Muscle Function
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.ABSTRACT Background Heme oxygenases, HO‐1 (Hmox1) and HO‐2 (Hmox2), regulate skeletal muscle homeostasis by degrading heme and generating carbon monoxide (CO), a bioactive signalling molecule. Although HO‐1 is known to influence muscle fibre composition and mitochondrial function, the role of HO‐2 in activity‐dependent neuromuscular plasticity remains ...
Rodrigo W. Alves de Souza +8 more
wiley +1 more source
Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance. [PDF]
, 2019 A mammalian cell houses two genomes located separately in the nucleus and mitochondria. During evolution, communications and adaptations between these two genomes occur extensively to achieve and sustain homeostasis for cellular functions and ...
Jiang, Nian +3 more
core