Results 31 to 40 of about 783,471 (282)

12621 Targeted Chemical-Genetic Screen Platform for Identifying Drug Modes-of-Action

Journal of Clinical and Translational Science, 2021
IMPACT: The key to advancing precision medicine is to deepen our understanding of drug modes-of-action (MOA). This project aims to develop a novel method for predicting MOA of potential drug compounds, providing an experimental and computational platform
Kevin Lin, Maximilian Billmann, Henry Ward, Ya-Chu Chang, Anja-Katrin Bielinsky, Chad L. Myers   +5 more
doaj   +1 more source

Drug metabolism and liver disease: a drug–gene–environment interaction [PDF]

, 2017
Despite the central role of the liver in drug metabolism, surprisingly there is lack of certainty in anticipating the extent of modification of the clearance of a given drug in a given patient.
Khoueiry-Zgheib, Nathalie, Branch, Robert A.   +1 more
core   +1 more source

Drug-gene interaction networks.

, 2023
Type 2 diabetes (T2D) is one of the major metabolic disorders in humans caused by hyperglycemia and insulin resistance syndrome. Although significant genetic effects on T2D pathogenesis are experimentally proved, the molecular mechanism of T2D in South ...
Md. Golam Rabby (13514311), Md. Numan Islam (13514308), Md. Mahmudul Hasan (8520969), Md. Mostafa Kamal (13514317), Mrityunjoy Biswas (708113), Md. Hafizur Rahman (7440173), Mantasa Bonny (17636492)   +6 more
core   +1 more source

Investigating drug–target interactions in frontotemporal dementia using a network pharmacology approach

Beni-Suef University Journal of Basic and Applied Sciences, 2021
Background Frontotemporal dementia (FTD) is the second most common type of dementia in individuals aged below 65 years with no current cure. Current treatment plan is the administration of multiple medications.
Archana Balasubramanian, Raksha Sudarshan, Jhinuk Chatterjee   +2 more
doaj   +1 more source

PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α

Cells, 2021
Background: PXR is a xenobiotic-responsive nuclear receptor that controls the expression of drug-metabolizing enzymes. Drug-induced activation of PXR sometimes causes drug–drug interactions due to the induced metabolism of co-administered drugs.
Ryota Shizu, Kanako Ezaki, Takumi Sato, Ayaka Sugawara, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari   +6 more
doaj   +1 more source

Gene-Drug Interaction in Stroke

Stroke Research and Treatment, 2011
Stroke is the third cause of mortality and one of most frequent causes of long-term neurological disability, as well as a complex disease that results from the interaction of environmental and genetic factors.
Serena Amici, Maurizio Paciaroni, Giancarlo Agnelli, Valeria Caso   +3 more
doaj   +1 more source

Pre-clinical drug prioritization via prognosis-guided genetic interaction networks. [PDF]

PLoS ONE, 2010
The high rates of failure in oncology drug clinical trials highlight the problems of using pre-clinical data to predict the clinical effects of drugs. Patient population heterogeneity and unpredictable physiology complicate pre-clinical cancer modeling ...
Jianghui Xiong, Juan Liu, Simon Rayner, Ze Tian, Yinghui Li, Shanguang Chen   +5 more
doaj   +1 more source

Prediction of Drug–Gene Interaction by Using Metapath2vec

Frontiers in Genetics, 2018
Heterogeneous information networks (HINs) currently play an important role in daily life. HINs are applied in many fields, such as science research, e-commerce, recommendation systems, and bioinformatics.
Siyi Zhu, Jiaxin Bing, Xiaoping Min, Chen Lin, Xiangxiang Zeng, Xiangxiang Zeng   +5 more
doaj   +1 more source

Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]

, 2006
Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
Glasspool, R.M., Teodoridis, JM, Glasspool, RM, Teodoridis, J.M., Brown, R, R M Glasspool, Brown, R., J M Teodoridis, R Brown   +8 more
core   +1 more source

Expression of drug transporters in intestine and blood [PDF]

, 2005
Proteins that are capable to transport molecules across membranes are fundamental for the accurate functioning of the body. Many diseases have their cause in a dysfunction of a particular transport protein.
Zimmermann, Christian
core   +1 more source