Results 21 to 30 of about 8,468,954 (280)

Physiologically Based Pharmacokinetic Model to Assess the Drug-Drug-Gene Interaction Potential of Belzutifan in Combination With Cyclin-Dependent Kinase 4/6 Inhibitors. [PDF]

JCO Precis Oncol
PURPOSE Belzutifan is a novel treatment for von Hippel-Lindau–associated cancers and is being evaluated in clinical trials for the treatment of renal cell carcinoma in combination with the cyclin-dependent kinase 4/6 inhibitors abemaciclib (ClinicalTrials.gov identifier: NCT04627064 ...
Meiman D, Skaar TC, Shugg T, Quinney SK.
europepmc   +3 more sources

Drug repositioning in non-small cell lung cancer (NSCLC) using gene co-expression and drug–gene interaction networks analysis

Scientific Reports, 2022
Lung cancer is the most common cancer in men and women. This cancer is divided into two main types, namely non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Around 85 to 90 percent of lung cancers are NSCLC.
Habib MotieGhader, Parinaz Tabrizi-Nezhadi, Mahshid Deldar Abad Paskeh, Behzad Baradaran, Ahad Mokhtarzadeh, Mehrdad Hashemi, Hossein Lanjanian, Seyed Mehdi Jazayeri, Masoud Maleki, Ehsan Khodadadi, Sajjad Nematzadeh, Farzad Kiani, Mazaher Maghsoudloo, Ali Masoudi-Nejad   +13 more
doaj   +1 more source

Text Mining-Based Drug Discovery for Connective Tissue Disease–Associated Pulmonary Arterial Hypertension

Frontiers in Pharmacology, 2022
Background: The current medical treatments for connective tissue disease–associated pulmonary arterial hypertension (CTD-PAH) do not show favorable efficiency for all patients, and identification of novel drugs is desired.Methods: Text mining was ...
Jiang-Shan Tan, Song Hu, Ting-Ting Guo, Lu Hua, Xiao-Jian Wang   +4 more
doaj   +1 more source

Drug metabolism and liver disease: a drug–gene–environment interaction [PDF]

, 2017
Despite the central role of the liver in drug metabolism, surprisingly there is lack of certainty in anticipating the extent of modification of the clearance of a given drug in a given patient.
Khoueiry-Zgheib, Nathalie, Branch, Robert A.   +1 more
core   +1 more source

Drug-drug interactions in the hospital [PDF]

, 2007
Introduction Drug interaction screening programs are an important tool to check prescriptions of multiple drugs for potential drug-drug interactions (pDDIs). Several programs are available on the market.
Vonbach, Priska
core   +1 more source

Impact of study design and statistical model in pharmacogenetic studies with gene‐treatment interaction

CPT: Pharmacometrics & Systems Pharmacology, 2021
Gene‐treatment interactions, just like drug‐drug interactions, can have dramatic effects on a patient response and therefore influence the clinician decision at the patient’s bedside.
Camille Couffignal, France Mentré, Julie Bertrand   +2 more
doaj   +1 more source

12621 Targeted Chemical-Genetic Screen Platform for Identifying Drug Modes-of-Action

Journal of Clinical and Translational Science, 2021
IMPACT: The key to advancing precision medicine is to deepen our understanding of drug modes-of-action (MOA). This project aims to develop a novel method for predicting MOA of potential drug compounds, providing an experimental and computational platform
Kevin Lin, Maximilian Billmann, Henry Ward, Ya-Chu Chang, Anja-Katrin Bielinsky, Chad L. Myers   +5 more
doaj   +1 more source

Drug-gene interaction and druggable genes associated with each GO process in each ML cluster.

, 2023
Drug-gene interaction and druggable genes associated with each GO process in each ML cluster.
Sudhanshu Shukla (408600), S. R. M. Prasanna (13236801), Seema Khadirnaikar (9227318)   +2 more
core   +1 more source

Investigating drug–target interactions in frontotemporal dementia using a network pharmacology approach

Beni-Suef University Journal of Basic and Applied Sciences, 2021
Background Frontotemporal dementia (FTD) is the second most common type of dementia in individuals aged below 65 years with no current cure. Current treatment plan is the administration of multiple medications.
Archana Balasubramanian, Raksha Sudarshan, Jhinuk Chatterjee   +2 more
doaj   +1 more source

Gene-Drug Interaction in Stroke

Stroke Research and Treatment, 2011
Stroke is the third cause of mortality and one of most frequent causes of long-term neurological disability, as well as a complex disease that results from the interaction of environmental and genetic factors.
Serena Amici, Maurizio Paciaroni, Giancarlo Agnelli, Valeria Caso   +3 more
doaj   +1 more source