Results 21 to 30 of about 598,220 (234)

Drug Repurposing Using Modularity Clustering in Drug-Drug Similarity Networks Based on Drug–Gene Interactions

Pharmaceutics, 2021
Drug repurposing is a valuable alternative to traditional drug design based on the assumption that medicines have multiple functions. Computer-based techniques use ever-growing drug databases to uncover new drug repurposing hints, which require further ...
Vlad Groza, Mihai Udrescu, Alexandru Bozdog, Lucreţia Udrescu   +3 more
doaj   +1 more source

Systematic Prediction of Antifungal Drug Synergy by Chemogenomic Screening in Saccharomyces cerevisiae

Frontiers in Fungal Biology, 2021
Since the earliest days of using natural remedies, combining therapies for disease treatment has been standard practice. Combination treatments exhibit synergistic effects, broadly defined as a greater-than-additive effect of two or more therapeutic ...
Hamid Gaikani, Hamid Gaikani, Andrew M. Smith, Anna Y. Lee, Guri Giaever, Corey Nislow, Corey Nislow   +6 more
doaj   +1 more source

A Review of Current In Silico Methods for Repositioning Drugs and Chemical Compounds

Frontiers in Oncology, 2021
Drug repositioning is a new way of applying the existing therapeutics to new disease indications. Due to the exorbitant cost and high failure rate in developing new drugs, the continued use of existing drugs for treatment, especially anti-tumor drugs ...
Binsheng He, Fangxing Hou, Changjing Ren, Changjing Ren, Pingping Bing, Xiangzuo Xiao   +5 more
doaj   +1 more source

Pharmacogenomic network analysis of the gene-drug interaction landscape underlying drug disposition

Computational and Structural Biotechnology Journal, 2020
In recent decades the identification of pharmacogenomic gene-drug associations has evolved tremendously. Despite this progress, a major fraction of the heritable inter-individual variability remains elusive.
Yitian Zhou, Volker M. Lauschke
doaj   +1 more source

Physiologically Based Pharmacokinetic Model to Assess the Drug-Drug-Gene Interaction Potential of Belzutifan in Combination With Cyclin-Dependent Kinase 4/6 Inhibitors. [PDF]

JCO Precis Oncol
PURPOSE Belzutifan is a novel treatment for von Hippel-Lindau–associated cancers and is being evaluated in clinical trials for the treatment of renal cell carcinoma in combination with the cyclin-dependent kinase 4/6 inhibitors abemaciclib (ClinicalTrials.gov identifier: NCT04627064 ...
Meiman D, Skaar TC, Shugg T, Quinney SK.
europepmc   +3 more sources

Drug repositioning in non-small cell lung cancer (NSCLC) using gene co-expression and drug–gene interaction networks analysis

Scientific Reports, 2022
Lung cancer is the most common cancer in men and women. This cancer is divided into two main types, namely non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Around 85 to 90 percent of lung cancers are NSCLC.
Habib MotieGhader, Parinaz Tabrizi-Nezhadi, Mahshid Deldar Abad Paskeh, Behzad Baradaran, Ahad Mokhtarzadeh, Mehrdad Hashemi, Hossein Lanjanian, Seyed Mehdi Jazayeri, Masoud Maleki, Ehsan Khodadadi, Sajjad Nematzadeh, Farzad Kiani, Mazaher Maghsoudloo, Ali Masoudi-Nejad   +13 more
doaj   +1 more source

Text Mining-Based Drug Discovery for Connective Tissue Disease–Associated Pulmonary Arterial Hypertension

Frontiers in Pharmacology, 2022
Background: The current medical treatments for connective tissue disease–associated pulmonary arterial hypertension (CTD-PAH) do not show favorable efficiency for all patients, and identification of novel drugs is desired.Methods: Text mining was ...
Jiang-Shan Tan, Song Hu, Ting-Ting Guo, Lu Hua, Xiao-Jian Wang   +4 more
doaj   +1 more source

Impact of study design and statistical model in pharmacogenetic studies with gene‐treatment interaction

CPT: Pharmacometrics & Systems Pharmacology, 2021
Gene‐treatment interactions, just like drug‐drug interactions, can have dramatic effects on a patient response and therefore influence the clinician decision at the patient’s bedside.
Camille Couffignal, France Mentré, Julie Bertrand   +2 more
doaj   +1 more source

12621 Targeted Chemical-Genetic Screen Platform for Identifying Drug Modes-of-Action

Journal of Clinical and Translational Science, 2021
IMPACT: The key to advancing precision medicine is to deepen our understanding of drug modes-of-action (MOA). This project aims to develop a novel method for predicting MOA of potential drug compounds, providing an experimental and computational platform
Kevin Lin, Maximilian Billmann, Henry Ward, Ya-Chu Chang, Anja-Katrin Bielinsky, Chad L. Myers   +5 more
doaj   +1 more source

Investigating drug–target interactions in frontotemporal dementia using a network pharmacology approach

Beni-Suef University Journal of Basic and Applied Sciences, 2021
Background Frontotemporal dementia (FTD) is the second most common type of dementia in individuals aged below 65 years with no current cure. Current treatment plan is the administration of multiple medications.
Archana Balasubramanian, Raksha Sudarshan, Jhinuk Chatterjee   +2 more
doaj   +1 more source