Results 41 to 50 of about 783,471 (282)

Drug-gene interaction and druggable genes associated with each GO process in each ML cluster.

, 2023
Drug-gene interaction and druggable genes associated with each GO process in each ML cluster.
Sudhanshu Shukla (408600), S. R. M. Prasanna (13236801), Seema Khadirnaikar (9227318)   +2 more
core   +1 more source

Digoxin + Cyclosporine - contextualized potential drug-drug interaction clinical algorithm

, 2020
An algorithm developed for research purposes that summarizes the potential drug-drug interaction between digoxin and cyclosporine. The information is not advice, and should not be treated as such.
Contributors to the A Minimum Representation of Potential Drug-Drug Interaction Knowledge and Evidence - Technical and User-centered Foundation Specification
core   +1 more source

Towards personalized management of drug interactions: from drug-drug-interaction to drug-drug-gene-interaction [PDF]

, 2020
Drug-drug interactions (DDIs) are still an important contributor to ineffective treatment or deleterious side effects. Therefore, assessing the prevalence and clinical relevance of frequently observed potential DDIs is an important step towards improving medication safety.
openaire   +2 more sources

Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study [PDF]

BMC Medicine, 2020
Abstract Background The number of patients living with co-existing diseases is growing. This study aimed to assess the extent of multimorbidity, medication use, and drug- and gene-based interactions in patients following a non-ST elevation acute coronary syndrome (NSTE-ACS). Methods
Turner, RM, de Koning, EM, Fontana, V, Thompson, A, Pirmohamed, M   +4 more
openaire   +2 more sources

Potential drug interactions : exposure and management in hospital and ambulatory settings [PDF]

, 2006
Health care professionals are responsible to ensure safe dispensing and use of drug regimens involving the use of drug combinations that may interact and cause serious adverse events.
Indermitte, Jörg Lorenz
core   +1 more source

Big Data Management in Drug–Drug Interaction: A Modern Deep Learning Approach for Smart Healthcare [PDF]

, 2022
The detection and classification of drug–drug interactions (DDI) from existing data are of high importance because recent reports show that DDIs are among the major causes of hospital-acquired conditions and readmissions and are also necessary for ...
Hafiz Suliman Munawar, Khan, Sara Imran, Ullah, Fahim, Muhammad Waseem Akram, Salman, Muhammad, Fahim Ullah, Khalid Latif, Muhammad Salman, Latif, Khalid, Sara Imran Khan, Munawar, Hafiz Suliman, Akram, Muhammad Waseem   +11 more
core   +1 more source

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
Sylke Müller, Hideo Imamura (62469), Dujardin, J., Khanal, Basudha, Brunker, K., Brunker, Kirstyn, Kirstyn Brunker (181178), Graham H. Coombs (164011), Suman Rijal (181185), Imamura, Hideo, Jean-Claude Dujardin, M\ufcller, Sylke, Dujardin, Jean-Claude, Dujardin, J. C., Coombs, G. H., Muller, S., Jean-Claude Dujardin (56958), Decuypere, S., Coombs, G.H., Vanaerschot, M., Decuypere, Saskia, Coombs, Graham H, Rijal, S., Manu Vanaerschot, Sylke Müller (37476), Basudha Khanal, Khanal, B., Hideo Imamura, Kirstyn Brunker, Müller, Sylke, Coombs, Graham H., Vanaerschot, Manu, Imamura, H., Rijal, Suman, Saskia Decuypere, Basudha Khanal (181181), Saskia Decuypere (181176), Manu Vanaerschot (109210), Suman Rijal, Graham H Coombs   +39 more
core   +1 more source

Gene-network based analysis of human placental trophoblast subtypes identifies critical genes as potential targets of therapeutic drugs

Journal of Integrative Bioinformatics, 2023
During early pregnancy, extravillous trophoblasts (EVTs) play a crucial role in modifying the maternal uterine environment. Failures in EVT lineage formation and differentiation can lead to pregnancy complications such as preeclampsia, fetal growth ...
Lackner Andreas Ian, Pollheimer Jürgen, Latos Paulina, Knöfler Martin, Haider Sandra   +4 more
doaj   +1 more source

Novel network pharmacology methods for drug mechanism of action identification, pre-clinical drug screening and drug repositioning

, 2011
The high rates of failure in oncology drug clinical trials highlight the problems of using pre-clinical data to predict the clinical effects of drugs. Here we present two methodology innovations on network pharmacology modeling.
Jianghui Xiong
core   +1 more source

Potential Breast Anticancer Drug Targets Revealed by Differential Gene Regulatory Network Analysis and Molecular Docking: Neoadjuvant Docetaxel Drug as a Case Study

Cancer Informatics, 2018
Understanding gene-gene interaction and its causal relationship to protein-protein interaction is a viable route for understanding drug action at the genetic level, which is largely hindered by inability to robustly map gene regulatory networks. Here, we
Adel Aloraini, Karim M ElSawy
doaj   +1 more source