Results 61 to 70 of about 598,220 (234)

Drug Combination Recommendation Model for Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Pharmaceuticals
Background: Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS) are two common autoimmune disorders for which the choice of drug regimen is clinically crucial.
Ling Wang, Zhengyang Zhang, Ziheng Zhang, Tie Hua Zhou, Keun Ho Ryu   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Drug response prediction using graph representation learning and Laplacian feature selection

BMC Bioinformatics, 2022
Background Knowing the responses of a patient to drugs is essential to make personalized medicine practical. Since the current clinical drug response experiments are time-consuming and expensive, utilizing human genomic information and drug molecular ...
Minzhu Xie, Xiaowen Lei, Jianchen Zhong, Jianxing Ouyang, Guijing Li   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Hepatotoxicity and rhabdomyolysis in kidney transplant patient with COVID-19: possible role of remdesivir and atorvastatin drug-drug-gene interactions [PDF]

, 2022
Introduction: Because of very variable clinical presentation of COVID-19 and polypharmacy in elderly, sometimes is difficult to distinguish between the drug-drug, disease-drug or drug- druggene induced side effects. Description: A 63–year old Caucasian woman with kidney transplant, was hospitalized due to COVID-19 infection.
Božina, Tamara, Šimičević, Livija, Osmanović, Jelena, Božina, Nada, Ganoci, Lana   +4 more
openaire  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Drug-drug-gene interactions as mediators of adverse drug reactions to diclofenac and statins: a case report and literature review.

Arhiv za higijenu rada i toksikologiju, 2021
Concomitant treatment with drugs that inhibit drug metabolising enzymes and/or transporters, such as commonly prescribed statins and nonsteroidal anti- inflammatory drugs (NSAIDs), has been associated with prolonged drug exposure and increased risk of adverse drug reactions (ADRs) due to drug-drug interactions. The risk is further increased in patients
Božina, Nada, Ganoci, Lana, Šimičević, Livija, Gvozdanović, Katarina, Klarica Domjanović, Iva, Borić Bilušić, Ana, Laganović, Mario, Božina, Tamara   +7 more
openaire   +1 more source

Protocol to estimate the heritability of drug response with GxEMM and identify gene-drug interactions with TxEWAS

STAR Protocols
Summary: Identifying factors that affect treatment response is a central objective of clinical research. Here, we present a protocol to study the genetic architecture of response to commonly prescribed drugs using gene-context interaction techniques.
Michal Sadowski, Andy W. Dahl, Noah Zaitlen   +2 more
doaj   +1 more source