Results 1 to 10 of about 5,280 (85)
Clinical management of patients with drug-induced liver injury (DILI). [PDF]
United European Gastroenterol J, 2021 AbstractDrug‐induced liver injury (DILI) should be considered in all patients with recent elevation of liver tests without obvious etiology and normal hepatobiliary imaging. There is currently no biomarker that is helpful in diagnosis which relies on clinical and laboratory findings.
Björnsson ES.
europepmc +5 more sources
Biomarkers of idiosyncratic drug-induced liver injury (DILI) - a systematic review. [PDF]
Expert Opin Drug Metab Toxicol, 2021 Idiosyncratic drug-induced liver injury (DILI) is an unpredictable event, and there are no specific biomarkers that can distinguish DILI from alternative explanations or predict its clinical outcomes. This systematic review summarizes the available evidence for all biomarkers proposed to have a role in the diagnosis or prognosis of DILI.
Atallah E +6 more
europepmc +9 more sources
The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment. [PDF]
Metabolites, 2022 Drug-induced liver injury (DILI) is one of the most frequent adverse clinical reactions and a relevant cause of morbidity and mortality. Hepatotoxicity is among the major reasons for drug withdrawal during post-market and late development stages, representing a major concern to the pharmaceutical industry.
Moreno-Torres M, Quintás G, Castell JV.
europepmc +6 more sources
Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes. [PDF]
Arch Toxicol, 2021 AbstractDrug-induced liver injury (DILI) is an adverse toxic hepatic clinical reaction associated to the administration of a drug that can occur both at early clinical stages of drug development, as well after normal clinical usage of approved drugs. Because of its unpredictability and clinical relevance, it is of medical concern. Three DILI phenotypes
Quintás G +5 more
europepmc +6 more sources
When Is Suspected Drug-Induced Liver Injury (DILI) Not DILI? An Analysis of Unlikely Cases From the Drug-Induced Liver Injury Network. [PDF]
Am J Gastroenterol, 2023 INTRODUCTION: Diagnosis of drug-induced liver injury (DILI) is difficult. We reviewed cases in the DILI Network prospective study that were adjudicated to have liver injury due to other causes to discover pearls for improved diagnostic accuracy.
Barritt AS +6 more
europepmc +3 more sources
Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)-In Vitro Testing. [PDF]
Pharmaceutics, 2022 Bile acids and bile salts (BA/BS) are substrates of both influx and efflux transporters on hepatocytes. Canalicular efflux transporters, such as BSEP and MRP2, are crucial for the removal of BA/BS to the bile. Basolateral influx transporters, such as NTCP, OATP1B1/1B3, and OSTα/β, cooperate with canalicular transporters in the transcellular vectorial ...
Tátrai P, Erdő F, Krajcsi P.
europepmc +4 more sources
Overview of Causality Assessment for Drug-Induced Liver Injury (DILI) in Clinical Trials. [PDF]
Drug Saf, 2021 Causality assessment for suspected drug-induced liver injury (DILI) during drug development and following approval is challenging. The IQ DILI Causality Working Group (CWG), in collaboration with academic and regulatory subject matter experts (SMEs), developed this manuscript with the following objectives: (1) understand and describe current practices;
Hey-Hadavi J +16 more
europepmc +5 more sources
Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues. [PDF]
Ann Transl Med, 2021 Clinical features of idiosyncratic drug induced liver injury (DILI) are well described in cases that have been assessed for causality using the Roussel Uclaf Causality Assessment Method (RUCAM), but our understanding of the mechanistic steps leading to injury is fragmentary.
Teschke R, Uetrecht J.
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Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure. [PDF]
Biol Direct, 2021 Abstract Background: Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are urgently needed.
Liu A +7 more
europepmc +8 more sources
Mortality associated with drug-induced liver injury (DILI). [PDF]
Transl Gastroenterol Hepatol, 2017 Idiosyncratic drug-induced liver injury (DILI) is an important cause of liver failure and liver injury leading to transplantation, although in most cases self-remitting when administration of the offending drug is stopped (1-3). In rare cases DILI can lead to a persistent/chronic form of injury (4).
Björnsson ES, Björnsson HK.
europepmc +5 more sources