Results 101 to 110 of about 12,091 (224)

Paracetamol-induced liver injury modelled in Xenopus laevis embryos [PDF]

, 2019
Introduction: Failure to predict drug-induced liver injury (DILI) remains a major contributing factor to lead compound drop-out during drug development. Xenopus embryos are amenable for early stage medium throughput small molecule screens and so have the
Saide, Katy, Sherwood, Victoria, Wheeler, Grant N.   +2 more
core   +3 more sources

Immunology Highlights of Four Major Idiosyncratic DILI Subtypes Verified by the RUCAM: A New Evidence-Based Classification

Livers
Conventionally, drug-induced liver injury (DILI) exists in two types: idiosyncratic and intrinsic. Both types are classified as non-immune disorders, thereby ignoring that some iDILI cases may have an immune or autoimmune background that requires a ...
Rolf Teschke
doaj   +1 more source

Update of the statement on safety of cannabidiol as a novel food

EFSA Journal, Volume 24, Issue 2, February 2026.
Abstract During the assessment of cannabidiol (CBD) as a novel food, in 2022 the NDA Panel identified significant data gaps. Concerns focused on potential adverse effects on the liver, gastrointestinal tract, endocrine, nervous and reproductive systems.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Francesco Cubadda, Helle Katrine Knutsen, Harry J. McArdle, Peter Moldeus, Monika Neuhäuser‐Berthold, Josef Rudolf Schlatter, Alexandros Siskos, Viviana Trezza, Océane Albert, Elisa Beneventi, Irene Nuin Garciarena, George E. N. Kass, Marcello Laganaro, Annamaria Rossi, Alejandra Muñoz, Areti Favata, Anna Maria Pieger, Maura Magani, Karen Ildico Hirsch‐Ernst   +33 more
wiley   +1 more source

Pathophysiological Differences and Differential Diagnosis of Autoimmune and Drug-Induced Hepatitis

Livers
Autoimmune hepatitis (AIH) and drug-induced liver injury (DILI) are major causes of liver inflammation with distinct pathophysiology but overlapping clinical features.
Nicola Zeni, Alessandro Cristofani, Salvatore Silvio Piano, Massimo Bolognesi, Antonietta Romano   +4 more
doaj   +1 more source

Quantitative Systems Toxicology Predicts Ivacaftor‐Induced Oxidative Stress Contributes to CFTR Modulator Hepatotoxicity

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 208-218, January 2026.
Cystic fibrosis (CF) is a chronic hereditary disease that affects tens of thousands of people worldwide. The introduction of CFTR modulator therapies such as elexacaftor/tezacaftor/ivacaftor (ETI) has significantly improved the quality of life of people with CF.
Alan Shi, Cole Cornwell, Kyunghee Yang, Paul M. Beringer   +3 more
wiley   +1 more source

Rivaroxaban-induced hepatotoxicity: review of the literature and report of new cases [PDF]

, 2018
Aim/Objective/Background Direct-acting oral anticoagulant drugs are marketed worldwide for the primary and secondary prevention and treatment of thromboembolic disorders.
Almasio, Pier Luigi, Giannitrapani, Lydia, Licata, Anna, Lombardo, Vania, Minissale, Maria G, Montalto, Giuseppe, Morreale, Ilaria, Puccia, Fania, Serruto, Antonietta, Soresi, Maurizio   +9 more
core   +1 more source

Vanillin Modulates the Sedative Effect of Diazepam, Possibly Through GABAergic Interaction Pathways in Thiopental Sodium‐Induced Sleeping Mice

Food Safety and Health, Volume 4, Issue 1, Page 220-232, January 2026.
Vanillin showed moderate sedative and modulatory synergistic activities on diazepam in thiopental sodium‐induced sleeping mice. These effects are implicated with GABAergic intervention. ABSTRACT Insomnia is a common sleep disorder affecting approximately 10% of adults.
Salehin Sheikh, Md. Shimul Bhuia, Raihan Chowdhury, Md. Sakib Al Hasan, Most. Israt Jahan Oni, Imam Hossen Rakib, Mir Imran Alim, Jakia Sultana, Muhammad Torequl Islam   +8 more
wiley   +1 more source

Drug-induced liver injuries (Part 1)

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2012
The aim of review. To present modern concepts on mechanisms of drug-induced liver injury (DILI), to give their classification, to present approaches to disease diagnostics.Original positions.
S. F. Galimova
doaj  

Drug-Induced Liver Injury (DILI): A Major Challenge [PDF]

Drug Research, 2021
openaire   +2 more sources

Determination of the Lethal Concentrations of Two Phenolic Acid Derivatives Originated From the Edible Red Marine Macroalga (Bangia fuscopurpurea) Using the In Vivo Zebrafish Eleutheroembryo Model and Their In Silico Structure–Toxicity Relationship Study

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
This study compared the predicted and experimental toxicity of two phenolic acid derivatives (HBP2 and HBP3) from the edible macroalga Bangia fuscopurpurea. HBP2 exhibited greater in vivo safety and lower predicted toxicity risks in silico, whereas HBP3 displayed higher in vitro cytotoxicity in IMR‐32 cells, potentially associated with the ...
Shi‐Ying Huang, Guiling Li, Yi‐Jia Shih, Chang‐Wei Hsieh, Yun‐Sheng Lin, Jingwen Liu, Tao Sun, Chien‐Wei Feng   +7 more
wiley   +1 more source