Results 131 to 140 of about 11,641 (246)

Risk of acute and serious liver injury associated to nimesulide and other NSAIDs: data from drug-induced liver injury case-control study in Italy [PDF]

, 2016
Aim: Drug-induced liver injury is one of the most serious adverse drug reactions and the most frequent reason for restriction of indications or withdrawal of drugs. Some nonsteroidal anti-inflammatory drugs (NSAIDs) were withdrawn from the market because
Arzenton, E., Bonaiuti, R., Bortolami, O., Capuano, A., Conforti, A., Donati, M., Lenti, M.C., Leone, R., Moretti, U., Motola, D., Rafaniello, C., Sportiello, L., Vaccheri, A., Vannacci, A.   +13 more
core   +2 more sources

Pathophysiological Differences and Differential Diagnosis of Autoimmune and Drug-Induced Hepatitis

Livers
Autoimmune hepatitis (AIH) and drug-induced liver injury (DILI) are major causes of liver inflammation with distinct pathophysiology but overlapping clinical features.
Nicola Zeni, Alessandro Cristofani, Salvatore Silvio Piano, Massimo Bolognesi, Antonietta Romano   +4 more
doaj   +1 more source

Mechanistic insights into antiretroviral drug‐induced liver injury

Pharmacology Research & Perspectives, 2020
All classes of antiretroviral therapy (ART) have been implicated to induce adverse drug reactions such drug‐induced liver injury (DILI) and immune‐mediated adverse reactions in Human Immunodeficiency Virus (HIV) infected individuals.
Jamie N. Pillaye, Mohlopheni J. Marakalala, Nonhlanhla Khumalo, Wendy Spearman, Hlumani Ndlovu   +4 more
doaj   +1 more source

Advancements and Challenges in Salivary Metabolomics for Early Detection and Monitoring of Systemic Diseases

MedComm, Volume 6, Issue 10, October 2025.
Salivary metabolomics offers a noninvasive and effective approach for early disease detection and monitoring. Salivary metabolites reflect systemic metabolism, inflammation, and external factors such as diet and stress. Advance in bioinformatics and machine learning facilitates the identification of metabolic biomarkers with high diagnostic accuracy ...
Xinyuan Zhao, Xu Chen, Zihao Zhou, Jiarong Zheng, Yunfan Lin, Yucheng Zheng, Rongwei Xu, Shen Hu, Li Cui   +8 more
wiley   +1 more source

Natural history and outcomes in drug induced autoimmune hepatitis [PDF]

, 2016
Aim: Drug-induced autoimmune hepatitis (DIAIH) remains poorly characterized. Our aim was to assess natural history and outcomes in DIAIH. Methods: This was a retrospective cohort study.
Alla, Alvarez, Andrade, Appleyard, Björnsson, Björnsson, Björnsson, Castiella, Castiella, Cohen, Danan, Feld, Heneghan, Heurgué, Kennedy, Kocman, Lawrenson, Licata, Lucena, MacGregor, Manns, Navarro, Roberts, Russo, Sakaan, Scully, Sharp, Shepherd, Sugimoto, Suzuki, Unzueta, Verma, Verma, Weiler-Normann   +33 more
core   +1 more source

Drug-Induced Liver Injury (DILI): A Major Challenge [PDF]

Drug Research, 2021
openaire   +2 more sources

Drug‐induced cholestasis

Hepatology Communications, 2017
Cholestatic drug‐induced liver injury (DILI) can be a diagnostic challenge due to a large differential diagnosis, variability in clinical presentation, and lack of serologic biomarkers associated with this condition.
Vinay Sundaram, Einar S. Björnsson
doaj   +1 more source

Predicting Systemic and Liver Bosentan Exposure Using Physiologically‐Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1715-1726, October 2025.
ABSTRACT Bosentan is the first approved oral medication for pulmonary arterial hypertension, yet the black‐box warning on its labeling implies a substantial risk of liver injury associated with bosentan exposure. The risk assessment of bosentan‐induced liver injury requires a thorough understanding of the underlying mechanisms, for which there is ...
Miao‐Chan Huang, Julia Macente, Sofie Heylen, Chen Ning, Kristof De Vos, Neel Deferm, Pieter Annaert   +6 more
wiley   +1 more source

Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury [PDF]

, 2015
Drug‐induced liver injury (DILI) frequently has a delayed onset with several human leukocyte antigen (HLA) genotypes affecting susceptibility, indicating a potential role for the adaptive immune system in the disease.
Abajo, Bomarrito, Britschgi, Cavani, Daly, Danan, Donaldson, Fontana, Jenkins, Kindmark, Li, Lucena, Lucena, Maria, Mauri-Hellweg, Metushi, Monshi, Mudnakudu Nagaraju, Naisbitt, Nattrass, O'Donohue, Pichler, Pichler, Sabat, Schaid, Singer, Spraggs, Stephens, Wu, Wu, Wuillemin, Wuillemin, Yanaba, Yanaba   +33 more
core   +1 more source

Drug-induced liver injuries (Part 1)

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2012
The aim of review. To present modern concepts on mechanisms of drug-induced liver injury (DILI), to give their classification, to present approaches to disease diagnostics.Original positions.
S. F. Galimova
doaj