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Highlight report: prediction of drug induced liver injury (DILI) with human hepatocytes in vitro [PDF]
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Correction to: Drug-Induced Liver Injury in the Elderly: Consensus Statements and Recommendations from the IQ-DILI Initiative [PDF]
Eric Cohen+13 more
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New classification of Drug Induced Liver Injury (DILI) in AASLD Guidance: What is next?
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American Journal of Gastroenterology, 2023
INTRODUCTION: Diagnosis of drug-induced liver injury (DILI) is difficult. We reviewed cases in the DILI Network prospective study that were adjudicated to have liver injury due to other causes to discover pearls for improved diagnostic accuracy.
A Sidney, Barritt+5 more
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INTRODUCTION: Diagnosis of drug-induced liver injury (DILI) is difficult. We reviewed cases in the DILI Network prospective study that were adjudicated to have liver injury due to other causes to discover pearls for improved diagnostic accuracy.
A Sidney, Barritt+5 more
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Role of immune reactions in drug-induced liver injury (DILI)
Drug Metabolism Reviews, 2012Although some drugs cause drug-induced liver injury (DILI) through direct damage to hepatocytes or intereference with bile secretion, others cause delayed, often idiosyncratic, DILI with clinical features, such as mild lymphocytic infiltrate, that are reminiscent of allergic reactions involving activation of the adaptive immune system. Even in cases of
Timothy P. Reilly, Changqing Ju
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Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment
Annals of Pharmacotherapy, 2019Background: Micafungin is increasingly used in the treatment and prevention of candidiasis in hospitalized patients. Limited data are available from which to assess the risk of drug-induced liver injury (DILI) with micafungin. No studies, to date, have applied a standardized causality assessment method to the study of micafungin-associated DILI ...
Caitlin Mullins+2 more
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Arzneimittel als Auslöser von Leberschäden [PDF]
Medikamenten-induzierte Leberschaden (Drug-induced liver injuries, DILI) fuhren zunachst zu auffalligen Leberparametern. Sie sind zwar selten, in den USA und Europa aber die haufigste Ursache fur das akute Leberversagen. Daher stellen sie eine wichtige Differenzialdiagnose dar. Der Hausarzt muss v. a. bei der Anamnese grundlich vorgehen.
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Global Epidemiology of Drug-Induced Liver Injury (DILI)
Current Hepatology Reports, 2019Drug-induced liver injury (DILI) is not an uncommon liver disease in many parts of the world. DILI is one of the most common causes of acute liver failure in most countries. The current review summarizes the global epidemiology of DILI. The number need to harm in terms of DILI due to amoxicillin-clavulanate was approximately 1 out 2300, but was higher ...
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