Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues. [PDF]
Ann Transl Med, 2021 Clinical features of idiosyncratic drug induced liver injury (DILI) are well described in cases that have been assessed for causality using the Roussel Uclaf Causality Assessment Method (RUCAM), but our understanding of the mechanistic steps leading to injury is fragmentary.
Teschke R, Uetrecht J.
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Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure. [PDF]
Biol Direct, 2021 Abstract Background: Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are urgently needed.
Liu A +7 more
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Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis. [PDF]
Int J Mol SciMoreno-Torres M +4 more
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Dyslipidemia is a Risk Factor for the Incidence and Severity of Drug-Induced Liver Injury (DILI): A Retrospective Population-Based Study in China. [PDF]
Med Sci Monit, 2019 Li X, Wang L, Li D, Niu J, Gao P.
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Mortality associated with drug-induced liver injury (DILI). [PDF]
Transl Gastroenterol Hepatol, 2017 Idiosyncratic drug-induced liver injury (DILI) is an important cause of liver failure and liver injury leading to transplantation, although in most cases self-remitting when administration of the offending drug is stopped (1-3). In rare cases DILI can lead to a persistent/chronic form of injury (4).
Björnsson ES, Björnsson HK.
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery. [PDF]
PLoS One, 2017 Peta V +24 more
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Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET] [PDF]
Journal of Hepatology, 2021 Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF) and one of the leading indications for liver transplantation in Western societies. Given the wide use of both prescribed and over the counter drugs, DILI has become a major health issue for which there is a pressing need to find novel and effective therapies.
José C. Fernández-Checa +20 more
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Genetic polymorphisms of CYP2C9 and CYP2C19 are not related to drug‐induced idiosyncratic liver injury (DILI) [PDF]
British Journal of Pharmacology, 2007 Background and purpose:The general view on the pathogenesis of drug‐induced idiosyncratic liver injury (DILI) is that parent compounds are rendered hepatotoxic by metabolism, mainly by cytochrome (CYP) 450, although other metabolic pathways can contribute. Anecdotal reports suggest a role of CYP 450 polymorphisms in DILI. We aimed to assess in a series
Ketevan Pachkoria +5 more
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Esbriet Pirfenidon medikamenteninduzierte Leberschdigung Drug-induced liver injury DILI [PDF]
Schweizerische Ärztezeitung, 2020 Roche Pharma Schweiz AG
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Drug-Induced Liver Injury in Tuberculosis: Mechanisms of Development and Diagnostic Methods
Juvenis Scientia, 2023 The review article discusses modern aspects of drug-induced liver injury (DILI) in patients with tuberculosis who are receiving etiotropic therapy. The main mechanisms of DILI, including toxic and idiosyncratic types, are described, as well as their ...
D. S. Sukhanov +3 more
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