Recurrent drug-induced liver injury (DILI) with ciprofloxacin and amoxicillin/clavulanic
Revista Española de Enfermedades Digestivas, 2015 Ciprofloxacin and amoxicillin/clavulanic are two widely used antibiotics due to their high efficacy and few side effects. While the percentage of hepatotoxicity of these antibiotics is low, their frequent use has led to a progressive increase in the number of cases.
Jordi Sánchez-Delgado +5 more
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Liver International, 2022 AbstractBackground & AimsNo multi‐national prospective study of drug‐induced liver injury (DILI) has originated in Europe. The design of a prospective European DILI registry, clinical features and short‐term outcomes of the cases and controls is reported.MethodsPatients with suspected DILI were prospectively enrolled in the United Kingdom, Spain ...
Björnsson, Einar S +13 more
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PP022—Variations in drug-induced liver injury (DILI) between different prospective dili registries
Clinical Therapeutics, 2013 e24 Volume 35 Number 8S PP022—VARIATIONS IN DRUG-INDUCED LIVER INJURY (DILI) BETWEEN DIFFERENT PROSPECTIVE DILI REGISTRIES I. Medina-Caliz; A. Gonzalez-Jimenez; F. Bessone; N. Hernandez; A. Sanchez; M. Di Pace; M. Arrese; J.R. Brahm; A. Ruiz; J. Arancibia; D. Kershenobich; A. Loaeza; M. Girala; N. Mendez-Sanchez; M. Davalos; M. Lizarzabal; E.
Milagros Dávalos +20 more
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The Liver Toxicity Knowledge Base (LKTB) and drug-induced liver injury (DILI) classification for assessment of human liver injury [PDF]
Expert Review of Gastroenterology & Hepatology, 2017 Drug-induced liver injury (DILI) is challenging for drug development, clinical practice and regulation. The Liver Toxicity Knowledge Base (LTKB) provides essential data for DILI study. Areas covered: The LTKB provided various types of data that can be used to assess and predict DILI.
Hong Fang +5 more
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Genetic polymorphisms of CYP2C9 and CYP2C19 are not related to drug‐induced idiosyncratic liver injury (DILI) [PDF]
British Journal of Pharmacology, 2007 Background and purpose:The general view on the pathogenesis of drug‐induced idiosyncratic liver injury (DILI) is that parent compounds are rendered hepatotoxic by metabolism, mainly by cytochrome (CYP) 450, although other metabolic pathways can contribute. Anecdotal reports suggest a role of CYP 450 polymorphisms in DILI. We aimed to assess in a series
Pachkoria, K. +5 more
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The rediscovery of HepG2 cells for prediction of drug induced liver injury (DILI)
EXCLI journal, 2014 EXCLI Journal ; Vol.
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Drug Induced Liver Injury (Dili) and Non Alcoholic Fatty Liver Disease (Nafld)
European Journal of Medical and Health Sciences, 2020 This review article includes a review of the latest literature searched on PubMed in the field of hepatotoxicity caused by drugs that have a wide daily application. The concept of the review article consists of several parts dealing with the definition of drugs induced liver injury - DILI, diagnostic challenges related to it, and the clinical spectrum ...
Nikola Malešević +3 more
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Drug-Induced Liver Injury (DILI): A Major Challenge [PDF]
Drug Research, 2021 openaire +2 more sources
Infliximab (IFX)-Biosimilar Induced Drug-Induced Liver Injury (DILI): A Case Report. [PDF]
Cureus, 2022 Zachou M +4 more
europepmc +1 more source
Deriving time-concordant event cascades from gene expression data: A case study for Drug-Induced Liver Injury (DILI). [PDF]
PLoS Comput Biol, 2022 Liu A +3 more
europepmc +1 more source