Case of cholestatic drug-induced liver injury (DILI) associated with black cohosh. [PDF]
BMJ Case Rep, 2021 Drug-induced liver injury is an uncommon yet fatal cause of liver injury. Black cohosh is a herbal supplement that is derived from Actaea racemosa. It has been used for vasomotor symptoms in postmenopausal women, but it can cause liver injury. A 50-year-old Afro-American woman presented with a 2-month history of malaise, itching and severe jaundice ...
Brar HS, Marathi R.
europepmc +6 more sources
Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives. [PDF]
Curr Drug Metab, 2018 Drug-induced Liver Injury (DILI) is an important cause of acute liver failure cases in the United States, and remains a common cause of withdrawal of drugs in both preclinical and clinical phases.A structured search of bibliographic databases - Web of Science Core Collection, Scopus and Medline for peer-reviewed articles on models of DILI was performed.
Kuna L +8 more
europepmc +5 more sources
Biomarkers of idiosyncratic drug-induced liver injury (DILI) - a systematic review. [PDF]
Expert Opin Drug Metab Toxicol, 2021 Idiosyncratic drug-induced liver injury (DILI) is an unpredictable event, and there are no specific biomarkers that can distinguish DILI from alternative explanations or predict its clinical outcomes. This systematic review summarizes the available evidence for all biomarkers proposed to have a role in the diagnosis or prognosis of DILI.
Atallah E +6 more
europepmc +9 more sources
A case report of a drug-induced liver injury (DILI) caused by multiple antidepressants with causality established by the updated Roussel Uclaf causality assessment method (RUCAM) and in vitro testing. [PDF]
Clin Case Rep, 2020 González-Muñoz M +8 more
europepmc +3 more sources
pDILI_v1: A Web-Based Machine Learning Tool for Predicting Drug-Induced Liver Injury (DILI) Integrating Chemical Space Analysis and Molecular Fingerprints. [PDF]
ACS OmegaAmin SA, Kar S, Piotto S.
europepmc +3 more sources
Diagnostic Dilemma in a Septuagenarian Patient: Drug-Induced Liver Injury (DILI) or Autoimmune Hepatitis? [PDF]
CureusNnonyelu C.
europepmc +2 more sources
When Is Suspected Drug-Induced Liver Injury (DILI) Not DILI? An Analysis of Unlikely Cases From the Drug-Induced Liver Injury Network. [PDF]
Am J Gastroenterol, 2023 INTRODUCTION: Diagnosis of drug-induced liver injury (DILI) is difficult. We reviewed cases in the DILI Network prospective study that were adjudicated to have liver injury due to other causes to discover pearls for improved diagnostic accuracy.
Barritt AS +6 more
europepmc +3 more sources
Comprehensive analysis of high-throughput transcriptomics to distinguish drug-induced liver injury (DILI) phenotypes. [PDF]
Arch ToxicolShin S, Lee C, Park T.
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Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)-In Vitro Testing. [PDF]
Pharmaceutics, 2022 Bile acids and bile salts (BA/BS) are substrates of both influx and efflux transporters on hepatocytes. Canalicular efflux transporters, such as BSEP and MRP2, are crucial for the removal of BA/BS to the bile. Basolateral influx transporters, such as NTCP, OATP1B1/1B3, and OSTα/β, cooperate with canalicular transporters in the transcellular vectorial ...
Tátrai P, Erdő F, Krajcsi P.
europepmc +4 more sources
S2840 Drug-Induced Liver Injury (DILI) Secondary to Kratom Use
American Journal of Gastroenterology, 2021 Ali Wakil +4 more
openalex +4 more sources