Results 31 to 40 of about 12,201 (250)

The Liver Toxicity Knowledge Base (LKTB) and drug-induced liver injury (DILI) classification for assessment of human liver injury [PDF]

Expert Review of Gastroenterology & Hepatology, 2017
Drug-induced liver injury (DILI) is challenging for drug development, clinical practice and regulation. The Liver Toxicity Knowledge Base (LTKB) provides essential data for DILI study. Areas covered: The LTKB provided various types of data that can be used to assess and predict DILI.
Shraddha Thakkar, Minjun Chen, Hong Fang, Zhichao Liu, Ruth Roberts, Weida Tong   +5 more
openalex   +4 more sources

A Case of Suspected Lisdexamfetamine (Vyvanse) Drug-Induced Liver Injury [PDF]

, 2023
Amphetamines are a well-established cause of liver injury though the typical presentation is that of illicit drug abuse rather than liver injury occurring in a prescribed setting.1 Lisdexamfetamine (Vyvanse) is one of the most commonly prescribed ...
Ahmed, MD, Monjur, Bilello, MD, Justin, Flerova, MD, Elizaveta, Kishfy, MD, Louis   +3 more
core   +2 more sources

Case of Ibuprofen-Induced Liver Injury

Annals of Internal Medicine: Clinical Cases, 2023
Drug-induced liver injury (DILI) resulting from nonsteroidal anti-inflammatory drugs (NSAIDs) is a rare phenomenon; however, several cases have been reported in the literature and the LiverTox database.
Kirsten Wong, Beda Cha, Simon Wu
doaj   +1 more source

Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans

Nature Communications, 2023
Diagnosis of rare, unpredictable, drug-induced liver injury (DILI) is a significant challenge for patients, clinicians, and drug development. Here, the authors discover, evaluate, and validate potential blood biomarkers to diagnose DILI and distinguish ...
Kodihalli C. Ravindra, Vishal S. Vaidya, Zhenyu Wang, Joel D. Federspiel, Richard Virgen-Slane, Robert A. Everley, Jane I. Grove, Camilla Stephens, Mireia F. Ocana, Mercedes Robles-Díaz, M. Isabel Lucena, Raul J. Andrade, Edmond Atallah, Alexander L. Gerbes, Sabine Weber, Helena Cortez-Pinto, Andrew J. Fowell, Hyder Hussaini, Einar S. Bjornsson, Janisha Patel, Guido Stirnimann, Sumita Verma, Ahmed M. Elsharkawy, William J. H. Griffiths, Craig Hyde, James W. Dear, Guruprasad P. Aithal, Shashi K. Ramaiah   +27 more
doaj   +1 more source

Inhibition of canalicular and sinusoidal taurocholate efflux by cholestatic drugs in human hepatoma HepaRG cells

Biopharmaceutics &Drug Disposition, Volume 43, Issue 6, Page 265-271, December 2022., 2022
Effects of cholestatic drugs towards hepatic canalicular and sinusoidal secretion of bile acids were investigated using a biphasic functional assay in human hepatoma HepaRG cells. After an initial loading phase with taurocholate, cells were re‐incubated in taurocholate‐free medium (efflux phase), with or without calcium (for modulating the opening of ...
Marc Le Vée, Amélie Moreau, Elodie Jouan, Claire Denizot, Yannick Parmentier, Olivier Fardel   +5 more
wiley   +1 more source

Endoplasmic Reticulum Stress and Mitochondrial Stress in Drug-Induced Liver Injury

Molecules, 2023
Drug-induced liver injury (DILI) is a widespread and harmful disease closely linked to mitochondrial and endoplasmic reticulum stress (ERS). Globally, severe drug-induced hepatitis, cirrhosis, and liver cancer are the primary causes of liver-related ...
Sisi Pu, Yangyang Pan, Qian Zhang, Ting You, Tao Yue, Yuxing Zhang, Meng Wang   +6 more
doaj   +1 more source

Liver Injury Associated with Metamizole Exposure: Features of an Underestimated Adverse Event [PDF]

, 2021
INTRODUCTION AND OBJECTIVE The potential of metamizole to cause drug-induced liver injury (DILI) has received increasing attention. We investigated the distinguishing features of a case series comprising 32 patients with suspected metamizole-induced DILI.
Benesic, Andreas, Gerbes, Alexander L., Neumann, Jens, Weber, Sabine   +3 more
core   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Obliterative portal venopathy: A neglected and probably misdiagnosed disease with peculiar etiology in South America

JGH Open, Volume 6, Issue 12, Page 904-909, December 2022., 2022
Classically described in the group of non‐cirrhotic portal hypertension, obliterative portal venopathy (OPV) causes are still unknown. Our aim is to describe the characteristics of 43 OPV patients and potential risk factors. Clinically significant portal hypertension was found in 28% of cases. The most frequent indication for liver biopsy was elevation
Vinícius Nunes, Luiz A R de Freitas, Juliana R de Freitas, Caio Araújo, Gildásio N Junior, Maria I Schinoni, Fernando Bessone, Raymundo Paraná   +7 more
wiley   +1 more source

Filter Drug-induced Liver Injury Literature with Natural Language Processing and Ensemble Learning [PDF]

, 2022
Drug-induced liver injury (DILI) describes the adverse effects of drugs that damage liver. Life-threatening results including liver failure or death were also reported in severe DILI cases. Therefore, DILI-related events are strictly monitored for all approved drugs and the liver toxicity became important assessments for new drug candidates. These DILI-
arxiv   +1 more source