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Study on Synergistic Effect of Bromocriptine and Sitagliptin in Streptozotocin-induced Diabetic Rats [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Diabetes mellitus is a potentially morbid condition with high prevalence worldwide. Restoration of euglycemia in type 2 diabetes mellitus is difficult to achieve due to its multifactorial pathogenesis and frequently requires multiple ...
Govindaraj Nileshraj +3 more
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Novel Developments to Enable Treatment of CNS Diseases with Targeted Drug Delivery
Pharmaceutics, 2023 The blood-brain barrier (BBB) is a major hurdle for the development of systemically delivered drugs against diseases of the central nervous system (CNS).
Axel H. Meyer +5 more
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Genomics, Proteomics & Bioinformatics, 2022 Combinatorial therapies have been recently proposed to improve the efficacy of anticancer treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug combination datasets.
Shuyu Zheng +7 more
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Antidepressant Effect of Neuropeptide Y in Models of Acute and Chronic Stress
Scientia Pharmaceutica, 2022 The search for potential effective antidepressants with minimal side effects is necessary. Peptides are possible applicants for this role. We investigated the antidepressant effect of neuropeptide Y (NY), alone and in combination with clomipramine, in ...
Nika Andriushchenko +10 more
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Biomolecules, 2022 CD38 was first discovered as a T-cell antigen and has since been found ubiquitously expressed in various hematopoietic cells, including plasma cells, NK cells, B cells, and granulocytes. More importantly, CD38 expression levels on malignant hematopoietic
Nurulhuda Mustafa +3 more
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Human Vaccines & Immunotherapeutics, 2020 Background: Older people (≥60 years old) are particularly vulnerable to influenza virus infection, and vaccine is effective in reducing the disease burden in this population. However, it remains obscure whether their antibody response is lower than those
Ziyan Meng +6 more
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Optimized 5-Fluorouridine Prodrug for Co-Loading with Doxorubicin in Clinically Relevant Liposomes
Pharmaceutics, 2021 Liposome-based drug delivery systems have allowed for better drug tolerability and longer circulation times but are often optimized for a single agent due to the inherent difficulty of co-encapsulating two drugs with differing chemical profiles. Here, we
Debra Wu +7 more
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New In Vitro-In Silico Approach for the Prediction of In Vivo Performance of Drug Combinations
Molecules, 2021 Pharmacokinetic (PK) studies improve the design of dosing regimens in preclinical and clinical settings. In complex diseases like cancer, single-agent approaches are often insufficient for an effective treatment, and drug combination therapies can be ...
Cristiana Correia +6 more
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Pharmaceutics, 2023 Chagas disease (CD) caused by the protozoan Trypanosoma cruzi affects more than six million people worldwide. Treatment is restricted to benznidazole (Bz) and nifurtimox (Nf) that display low activity in the later chronic stage besides triggering toxic ...
Raiza Brandão Peres +5 more
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Opioid Free Postoperative Pain Management in Day Case Surgery of Tonsillectomy [PDF]
International Journal of Medical Arts, 2020 Background: Post-surgical pain is a challenging problem. Different modifications of surgical procedures and use of different analgesics had been reported. However, no consensus had been reached for post-surgical pain control.
Sabri A. Soltan +2 more
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