Results 31 to 40 of about 2,583,563 (290)

Doxycycline Plus Trimethoprim-Sulfamethoxazole versus Doxycycline plus Rifampicin in Treatment of Brucellosis: A Randomized Controlled Trial

Al-Azhar Assiut Medical Journal, 2022
Background and aim Brucellosis is one of the most common endemic zoonotic diseases that have large animal and human burden. Many regimens of drug combinations are used for a variable period (at least 6 weeks).
Waleed A Hassan, Muhammad Abdel-Gawad, Ahmed S Abdelmohsen   +2 more
doaj   +1 more source

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, incurable cancer with a 20% 1 year survival rate. While standard-of-care therapy can prolong life in a small fraction of cases, PDAC is inherently resistant to current treatments, and novel ...
Adile, Ashley A., Bakhshinyan, David, Berger-Becvar, Angelika, de Araujo, Elvin D., Deininger, Michael W., Fishel, Melissa L., Gawel, Justyna M., Geletu, Mulu, Grimard, Michelle L., Gunning, Patrick T., Heaton, William L., Konieczny, Stephen F., Luchman, H. Artee, O'Hare, Thomas, Raouf, Yasir, Shah, Fenil, Shouksmith, Andrew E., Singh, Sheila K., Venugopal, Chitra, Weiss, Samuel   +19 more
core   +3 more sources

Combination of Oncolytic Measles Virus and Ursolic Acid Synergistically Induces Oncolysis of Hepatocellular Carcinoma Cells

Viruses, 2023
Hepatocellular carcinoma (HCC) remains a difficult-to-treat cancer due to late diagnosis and limited curative treatment options. Developing more effective therapeutic strategies is essential for the management of HCC.
Ching-Hsuan Liu, Chen-Jei Tai, Yu-Ting Kuo, Shen-Shong Chang, Liang-Tzung Lin   +4 more
doaj   +1 more source

Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism

BMC Cancer, 2020
Background Despite an improvement of prognosis in breast and colon cancer, the outcome of the metastatic disease is still severe. Microevolution of cancer cells often leads to drug resistance and tumor-recurrence.
Jérôme Ruhnau, Jonas Parczyk, Kerstin Danker, Britta Eickholt, Andreas Klein   +4 more
doaj   +1 more source

Effect of acupressure on smoking cessation in young smokers with nicotine dependence: A mixed methods study

Integrative Medicine Research
Background: Acupressure has been widely used to help people quit for a long time in China. This study explores the feasibility and effects of acupressure on smoking cessation in young smokers with nicotine dependence to inform policy and decision-making.
Ying-Ying Zhang, Yi-Jie Liu, Yuan Wang, Chen Shen, Shi-Bing Liang, Nicola Robinson, Hai-Fa Qiao, Jian-Ping Liu   +7 more
doaj   +1 more source

Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms

Frontiers in Pharmacology, 2022
Breast cancer is one of the most deadly malignancies in women worldwide. Salvia miltiorrhiza, a perennial plant that belongs to the genus Salvia, has long been used in the management of cardiovascular and cerebrovascular diseases.
Huan Zhao, Bing Han, Xuan Li, Chengtao Sun, Yufei Zhai, Man Li, Mi Jiang, Weiping Zhang, Yi Liang, Guoyin Kai   +9 more
doaj   +1 more source

A survey of Top 200 Drugs—Inconsistent Practice of Drug Strength Expression for Drugs Containing Salt Forms [PDF]

, 2012
Many ionizable drugs are developed and marketed as salt forms. However, there are no clear US regulatory guidelines on drug strength labeling for salts. The strengths of some drugs are expressed as salts and some as free acids/bases.
Prohotsky, Daniel, Zhao, Fang
core   +2 more sources

A Drug Combination Screen Identifies Drugs Active against Amoxicillin-induced Round Bodies of Borrelia burgdorferi Persisters from an FDA Drug Library

Frontiers in Microbiology, 2016
Although currently recommended antibiotics for Lyme disease such as doxycycline or amoxicillin cure the majority of the patients, about 10-20% of patients treated for Lyme disease may experience lingering symptoms including fatigue, pain, or joint and ...
Jie eFeng, Wanliang eShi, Shuo eZhang, David eSullivan, Paul eAuwaerter, Ying eZhang   +5 more
doaj   +1 more source

Can Twitter be a source of information on allergy? Correlation of pollen counts with tweets reporting symptoms of allergic rhinoconjunctivitis and names of antihistamine drugs [PDF]

, 2015
Pollen forecasts are in use everywhere to inform therapeutic decisions for patients with allergic rhinoconjunctivitis (ARC). We exploited data derived from Twitter in order to identify tweets reporting a combination of symptoms consistent with a case ...
Carloni, E, D'Ambrosio, A, Fiocchi, A, Gesualdo, F, Pandolfi, E, STILO, GIOVANNI, Tozzi, Ae, VELARDI, Paola   +7 more
core   +1 more source

Electroacupuncture alleviates motor dysfunction by regulating neuromuscular junction disruption and neuronal degeneration in SOD1G93A mice

Brain Research Bulletin
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by the progressive destruction of the neuromuscular junction (NMJ) and the degeneration of motor neurons, eventually leading to atrophy and paralysis of voluntary muscles ...
Junyang Liu, Weijia Zhao, Jie Guo, Kaiwen Kang, Hua Li, Xiaohang Yang, Jie Li, Qiang Wang, Haifa Qiao   +8 more
doaj   +1 more source