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Drug combinations targeting antibiotic resistance [PDF]

npj Antimicrobials and Resistance
While the rise of antibiotic resistance poses a global health challenge, the development of new antibiotics has slowed down over the past decades. This turned the attention of researchers towards the rational design of drug combination therapies to ...
Bence Bognár, Réka Spohn, Viktória Lázár   +2 more
doaj   +2 more sources

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations [PDF]

, 2014
Drug resistance, de novo and acquired, pervades cellular signaling networks (SNs) from one signaling motif to another as a result of cancer progression and/or drug intervention.
Bown, James L., Goltsov, Alexey, Goltsov, Gregory, Harrison, David J., Langdon, Simon P.   +4 more
core   +7 more sources

Synergistic and antagonistic drug combinations depend on network topology. [PDF]

PLoS ONE, 2014
Drug combinations may exhibit synergistic or antagonistic effects. Rational design of synergistic drug combinations remains a challenge despite active experimental and computational efforts.
Ning Yin, Wenzhe Ma, Jianfeng Pei, Qi Ouyang, Chao Tang, Luhua Lai   +5 more
doaj   +6 more sources

Network-based prediction of anti-cancer drug combinations [PDF]

Frontiers in Pharmacology
Drug combinations have emerged as a promising therapeutic approach in cancer treatment, aimed at overcoming drug resistance and improving the efficacy of monotherapy regimens.
Jue Jiang, Xuxu Wei, YuKang Lu, Simin Li, Xue Xu   +4 more
doaj   +2 more sources

piscesCSM: prediction of anticancer synergistic drug combinations [PDF]

Journal of Cheminformatics
While drug combination therapies are of great importance, particularly in cancer treatment, identifying novel synergistic drug combinations has been a challenging venture.
Raghad AlJarf, Carlos H. M. Rodrigues, Yoochan Myung, Douglas E. V. Pires, David B. Ascher   +4 more
doaj   +2 more sources

Novel Synergistic Anti-Enteroviral Drug Combinations

Viruses, 2022
Background: Enterovirus infections affect people around the world, causing a range of illnesses, from mild fevers to severe, potentially fatal conditions. There are no approved treatments for enterovirus infections. Methods: We have tested our library of
Aleksandr Ianevski, Eva Zusinaite, Tanel Tenson, Valentyn Oksenych, Wei Wang, Jan Egil Afset, Magnar Bjørås, Denis E. Kainov   +7 more
doaj   +1 more source

Oncology drug-companion diagnostic combinations

Cancer Treatment and Research Communications, 2021
With the development of trastuzumab for metastatic breast cancer a new era began in cancer drug development. The drug-diagnostic codevelopment model with its clinical enrichment trial design has enabled development of target specific drugs for molecular ...
Jan Trøst Jørgensen
doaj   +1 more source

Impact of additional selexipag on prostacyclin infusion analogs in patients with pulmonary arterial hypertension

Respiratory Medicine Case Reports, 2022
The effective therapy for pulmonary arterial hypertension (PAH) with inadequate clinical response is scarce except for lung transplantation when prostacyclin infusion is ineffective.
Mizuki Momoi, Takahiro Hiraide, Yoshiki Shinya, Hiromi Momota, Shogo Fukui, Michiyuki Kawakami, Keiichi Fukuda, Masaharu Kataoka   +7 more
doaj   +1 more source

Bifunctional antibiotic hybrids: A review of clinical candidates

Frontiers in Pharmacology, 2023
Antibiotic resistance is a top threat to human health and a priority across the globe. This problematic issue is accompanied by the decline of new antibiotics in the pipeline over the past 30 years.
Augustine Jing Jie Koh, Varsha Thombare, Maytham Hussein, Gauri G. Rao, Jian Li, Tony Velkov, Tony Velkov   +6 more
doaj   +1 more source

Immune Modulatory Effects of Molecularly Targeted Therapy and Its Repurposed Usage in Cancer Immunotherapy

Pharmaceutics, 2022
The fast evolution of anti-tumor agents embodies a deeper understanding of cancer pathogenesis. To date, chemotherapy, targeted therapy, and immunotherapy are three pillars of the paradigm for cancer treatment. The success of immune checkpoint inhibitors
Tiancheng Zhang, Chenhao Zhang, Zile Fu, Qiang Gao   +3 more
doaj   +1 more source