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Review of Predicting Synergistic Drug Combinations [PDF]

Life, 2023
The prediction of drug combinations is of great clinical significance. In many diseases, such as high blood pressure, diabetes, and stomach ulcers, the simultaneous use of two or more drugs has shown clear efficacy. It has greatly reduced the progression
Yichen Pan, Haotian Ren, Liang Lan, Yixue Li, Tao Huang   +4 more
doaj   +2 more sources

Drug combinations targeting antibiotic resistance [PDF]

npj Antimicrobials and Resistance
While the rise of antibiotic resistance poses a global health challenge, the development of new antibiotics has slowed down over the past decades. This turned the attention of researchers towards the rational design of drug combination therapies to ...
Bence Bognár, Réka Spohn, Viktória Lázár   +2 more
doaj   +2 more sources

Candyflipping and Other Combinations: Identifying Drug–Drug Combinations from an Online Forum [PDF]

Frontiers in Psychiatry, 2018
Novel psychoactive substances (NPS) refer to synthetic compounds or derivatives of more widely known substances of abuse that have emerged over the last two decades.
Michael Chary, David Yi, Alex F. Manini
doaj   +3 more sources

Synergistic and antagonistic drug combinations depend on network topology. [PDF]

PLoS ONE, 2014
Drug combinations may exhibit synergistic or antagonistic effects. Rational design of synergistic drug combinations remains a challenge despite active experimental and computational efforts.
Ning Yin, Wenzhe Ma, Jianfeng Pei, Qi Ouyang, Chao Tang, Luhua Lai   +5 more
doaj   +6 more sources

Network-based prediction of anti-cancer drug combinations [PDF]

Frontiers in Pharmacology
Drug combinations have emerged as a promising therapeutic approach in cancer treatment, aimed at overcoming drug resistance and improving the efficacy of monotherapy regimens.
Jue Jiang, Xuxu Wei, YuKang Lu, Simin Li, Xue Xu   +4 more
doaj   +2 more sources

piscesCSM: prediction of anticancer synergistic drug combinations [PDF]

Journal of Cheminformatics
While drug combination therapies are of great importance, particularly in cancer treatment, identifying novel synergistic drug combinations has been a challenging venture.
Raghad AlJarf, Carlos H. M. Rodrigues, Yoochan Myung, Douglas E. V. Pires, David B. Ascher   +4 more
doaj   +2 more sources

Drug interactions and lethal drug combinations [PDF]

Journal of Clinical Pathology, 1975
A. Richens
openalex   +5 more sources

TransferBAN-Syn: a transfer learning-based algorithm for predicting synergistic drug combinations against echinococcosis [PDF]

Frontiers in Genetics
Echinococcosis is a zoonotic parasitic disease caused by the larvae of echinococcus tapeworms infesting the human body. Drug combination therapy is highly valued for the treatment of echinococcosis because of its potential to overcome resistance and ...
Haitao Li, Haitao Li, Yuanyuan Chu, Yuanyuan Chu, Liyuan Jiang, Liyuan Jiang, Lei Li, Lei Li, GuoDong Lv, Yuansheng Liu, Chunhou Zheng, Chunhou Zheng, Yansen Su, Yansen Su   +13 more
doaj   +2 more sources

Letter: Drug combinations for anaesthesia. [PDF]

BMJ, 1975
Marc Hudson
openalex   +7 more sources

Novel Synergistic Anti-Enteroviral Drug Combinations

Viruses, 2022
Background: Enterovirus infections affect people around the world, causing a range of illnesses, from mild fevers to severe, potentially fatal conditions. There are no approved treatments for enterovirus infections. Methods: We have tested our library of
Aleksandr Ianevski, Eva Zusinaite, Tanel Tenson, Valentyn Oksenych, Wei Wang, Jan Egil Afset, Magnar Bjørås, Denis E. Kainov   +7 more
doaj   +1 more source