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Review of Predicting Synergistic Drug Combinations [PDF]

Life, 2023
The prediction of drug combinations is of great clinical significance. In many diseases, such as high blood pressure, diabetes, and stomach ulcers, the simultaneous use of two or more drugs has shown clear efficacy. It has greatly reduced the progression
Yichen Pan, Haotian Ren, Liang Lan, Yixue Li, Tao Huang   +4 more
doaj   +2 more sources

Drug combinations targeting antibiotic resistance [PDF]

npj Antimicrobials and Resistance
While the rise of antibiotic resistance poses a global health challenge, the development of new antibiotics has slowed down over the past decades. This turned the attention of researchers towards the rational design of drug combination therapies to ...
Bence Bognár, Réka Spohn, Viktória Lázár   +2 more
doaj   +2 more sources

Synergistic and antagonistic drug combinations depend on network topology. [PDF]

PLoS ONE, 2014
Drug combinations may exhibit synergistic or antagonistic effects. Rational design of synergistic drug combinations remains a challenge despite active experimental and computational efforts.
Ning Yin, Wenzhe Ma, Jianfeng Pei, Qi Ouyang, Chao Tang, Luhua Lai   +5 more
doaj   +6 more sources

Network-based prediction of anti-cancer drug combinations [PDF]

Frontiers in Pharmacology
Drug combinations have emerged as a promising therapeutic approach in cancer treatment, aimed at overcoming drug resistance and improving the efficacy of monotherapy regimens.
Jue Jiang, Xuxu Wei, YuKang Lu, Simin Li, Xue Xu   +4 more
doaj   +2 more sources

piscesCSM: prediction of anticancer synergistic drug combinations [PDF]

Journal of Cheminformatics
While drug combination therapies are of great importance, particularly in cancer treatment, identifying novel synergistic drug combinations has been a challenging venture.
Raghad AlJarf, Carlos H. M. Rodrigues, Yoochan Myung, Douglas E. V. Pires, David B. Ascher   +4 more
doaj   +2 more sources

Novel Synergistic Anti-Enteroviral Drug Combinations

Viruses, 2022
Background: Enterovirus infections affect people around the world, causing a range of illnesses, from mild fevers to severe, potentially fatal conditions. There are no approved treatments for enterovirus infections. Methods: We have tested our library of
Aleksandr Ianevski, Eva Zusinaite, Tanel Tenson, Valentyn Oksenych, Wei Wang, Jan Egil Afset, Magnar Bjørås, Denis E. Kainov   +7 more
doaj   +1 more source

Oncology drug-companion diagnostic combinations

Cancer Treatment and Research Communications, 2021
With the development of trastuzumab for metastatic breast cancer a new era began in cancer drug development. The drug-diagnostic codevelopment model with its clinical enrichment trial design has enabled development of target specific drugs for molecular ...
Jan Trøst Jørgensen
doaj   +1 more source

Impact of additional selexipag on prostacyclin infusion analogs in patients with pulmonary arterial hypertension

Respiratory Medicine Case Reports, 2022
The effective therapy for pulmonary arterial hypertension (PAH) with inadequate clinical response is scarce except for lung transplantation when prostacyclin infusion is ineffective.
Mizuki Momoi, Takahiro Hiraide, Yoshiki Shinya, Hiromi Momota, Shogo Fukui, Michiyuki Kawakami, Keiichi Fukuda, Masaharu Kataoka   +7 more
doaj   +1 more source

Eradication of Drug-Tolerant Mycobacterium tuberculosis 2022: Where We Stand

Microorganisms, 2023
The lungs of tuberculosis (TB) patients contain a spectrum of granulomatous lesions, ranging from solid and well-vascularized cellular granulomas to avascular caseous granulomas.
Alessio Lanni, Angelo Iacobino, Lanfranco Fattorini, Federico Giannoni   +3 more
doaj   +1 more source

Antifungal Combinations in Dermatophytes

Journal of Fungi, 2021
Dermatophytes are the most common cause of fungal infections worldwide, affecting millions of people annually. The emergence of resistance among dermatophytes along with the availability of antifungal susceptibility procedures suitable for testing ...
Lucia Brescini, Simona Fioriti, Gianluca Morroni, Francesco Barchiesi   +3 more
doaj   +1 more source