Evolving Experimental Techniques for Structure-Based Drug Design [PDF]
, 2022 Cody Aplin +4 more
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Social and environmental factors influencing in-prison drug use [PDF]
, 2011 Purpose – There is a strong political imperative to regard the prison as a key social setting for health promotion, but evidence indicates that drug misuse continues to be a significant issue for many prisoners.
Woodall, J
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Nothing Besides Remains: Preserving the Scientific and Cultural Value of Paleontological Resources in the United States [PDF]
, 2005 Receptor occupancy assessed by Positron Emission Tomography (PET) can provide important translational information to help bridge information from one drug to another or from animal to man.
Chew, Alexa Z.
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An Evolutionary Approach to Drug-Design Using Quantam Binary Particle Swarm Optimization Algorithm
, 2012 The present work provides a new approach to evolve ligand structures which represent possible drug to be docked to the active site of the target protein. The structure is represented as a tree where each non-empty node represents a functional group.
Chowdhury, Arkabandhu +3 more
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Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa [PDF]
, 2014 Substantial amounts of data have been generated from patient management and academic exercises designed to better understand the human immunodeficiency virus (HIV) epidemic and design interventions to control it.
Bester, Armand +17 more
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Scientific Reports, 2017 GPR139 is an orphan G protein-coupled receptor expressed in the brain, in particular in the habenula, hypothalamus and striatum. It has therefore been suggested that GPR139 is a possible target for metabolic disorders and Parkinson’s disease.
Anne Cathrine Nøhr +9 more
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Synthesis of the calcilytic ligand NPS 2143
Beilstein Journal of Organic Chemistry, 2013 (R)-3 (NPS 2143) is a negative allosteric modulator of the human calcium-sensing receptor (CaSR) and as such represents an important pharmacological tool compound for studying the CaSR.
Henrik Johansson +4 more
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DAPTEV: Deep aptamer evolutionary modelling for COVID-19 drug design [PDF]
, 2022 Cameron Andress +4 more
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Heliyon, 2019 Our group had previously reported the encapsulation efficiency of cyclic β-(1, 2)-glucan for various drugs. The current study is aimed at evaluating the use of glucan as a drug carrier system by blending with poly lactic-co- glycolic acid (L:G = 10:90 ...
Geetha Venkatachalam +3 more
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Spirituality, Religiosity, Depression, Anxiety, and Drug-Use Consequences During Methadone Maintenance Therapy [PDF]
, 2013 Substance addiction is damaging to the health of persons, families, and society. Often the person with addiction has decreased spirituality and religiosity and suffers from anxiety, depression, or both, increasing the risk for continued substance use and
Piacentine, Linda B.
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