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Drug-induced liver injury [PDF]

Clinical Medicine, 2016
Drug-induced liver injury (DILI) remains the most common cause of acute liver failure (ALF) in the western world. Excluding paractamol overdose, nearly all DILI encountered in the clinical setting is idiosyncratic in nature, since affected individuals ...
A, Amacher, Chalasani, Chen, Chien, El Sherrif, Hillman, Maggi, Russo, Sakaan, Studniarz, Suk, Yeong   +12 more
core   +7 more sources

Drug-induced liver injury [PDF]

Yeungnam University Journal of Medicine, 2020
Drug-induced liver injury (DILI), including herbal and dietary supplement hepatotoxicity, is often passed lightly; however, it can lead to the requirement of a liver transplant or may even cause death because of liver failure. Recently, the American College of Gastroenterology, Chinese Society of Hepatology and European Association for the Study of the
Jeong Ill Suh
openaire   +4 more sources

Ivermectin drug induced liver injury

South African Medical Journal, 2023
Ivermectin remains a popular, albeit unproven, therapy used in both the prevention and treatment of COVID-19. We discuss a patient who developed jaundice and a liver injury 3 weeks after initiating ivermectin for COVID prevention.  Liver histology demonstrated a pattern of injury that was both portal and lobular, with a bile ductulitis as well with ...
Sonderup, M W, Mudini, W, Spearman, C W N   +2 more
openaire   +5 more sources

Drug-induced liver injury [PDF]

, 2010
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Skoða/Opna(view/open)Drug-induced liver injury (DILI) is a well known adverse reaction of many drugs. Direct toxic liver damage is associated with paracetamol toxicity
Einar S. Björnsson
core   +2 more sources

Semaglutide-Induced Hepatic Injury: A Rare Case of Drug Induced Liver Injury. [PDF]

Clin Case Rep
Semaglutide, a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, is widely used for type 2 diabetes mellitus and has demonstrated hepatoprotective effects.
Kundu R, Shtoff L.
europepmc   +2 more sources

Drug-induced liver injury [PDF]

Canadian Medical Association Journal, 2021
Drug-induced liver injury is estimated to have an incidence of 14–19 cases per 100 000 individuals.[1][1],[2][2] Although asymptomatic liver enzyme elevation is the most common presentation, drug-induced liver injury is the most common cause of acute liver failure in most Western countries,
Kumachev, Alexander, Wu, Peter E.
openaire   +4 more sources

The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. [PDF]

, 2014
BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1 ...
A Tostmann, Atikaimu Wubuli, B Roy, B Roy, C Benichou, Corinne Merle, D Yee, DL Zhu, DS Huang, DW Hein, H Devarbhavi, HG Xie, HJ Cho, HJ De Rosa, HR An, HR An, I Vieira, J Meyer D, JH Wang, Jiayi Gu, Jinfeng Ma, JJ Saukkonen, JN Hirschhorn, JN Pande, JR Mitchell, JR Mitchell, Lei Yang, LG Possuelo, Long Ma, M Dossing, M Guo, M Guo, M Ingelman-Sundberg, M Ohno, M Runge-Morris, Mark Patrick Nicol, Mingqin Cao, N Vuilleumier, Paul Milligan, PD Bose, PD Roy, Qian Wang, Qian Wang, R Shakya, RC Strange, RL Teixeira, S Chatterjee, S Huang Y, S Russmann, S Sunahara, S Yamada, SH Kim, SH Kim, SK Sharma, SW Lee, SW Tang, T Mohri, T Sotsuka, T Wang, T Wang, T Yamamoto, V Leiro, Wei Liu, Weidong Wu, WJ Burman, WM Lee, WW Yew, Xia Zhu, Xiumei Xin, Xuemei Yao, XZ Lv, Y Chen, Yang Xiang, Ying Mao, YM Wu, Yongguang Li, YS Huang, YS Huang, YS Huang, YS Huang   +79 more
core   +16 more sources

Drug-Induced Liver Injury [PDF]

Mayo Clinic Proceedings, 2014
Drug hepatoxicity can be nonidiosyncratic (predictable), as in the case of acetaminophen, or idiosyncratic (unpredictable). This review article focuses primarily on idiosyncratic drug-induced liver injury (DILI). New epidemiologic data suggest that approximately 20 new cases of DILI per 100,000 persons occur each year.
Michael D, Leise, John J, Poterucha, Jayant A, Talwalkar   +2 more
  +5 more sources

Drug-induced liver injury [PDF]

Nature Reviews Disease Primers, 2019
Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that occurs either as a predictable event when an individual is exposed to toxic doses of some compounds or as an unpredictable event with many drugs in common use. Drugs can be harmful to the liver in susceptible individuals owing to genetic and environmental risk ...
Andrade, Raul J, Chalasani, Naga, Björnsson, Einar S, Suzuki, Ayako, Kullak-Ublick, Gerd A, Watkins, Paul B, Devarbhavi, Harshad, Merz, Michael, Lucena, M Isabel, Kaplowitz, Neil, Aithal, Guruprasad P   +10 more
  +9 more sources

Comparative Metabolomic Profiling of the Metabolic Differences of Δ9-Tetrahydrocannabinol and Cannabidiol

Molecules, 2022
More than one hundred cannabinoids have been found in cannabis. Δ9-Tetrahydrocannabinol (THC) is the recognized addictive constituent in cannabis; however, the mechanisms underlying THC-induced toxicity remain elusive.
Qianru Rao, Ting Zhang, Manyun Dai, Bin Li, Qianlun Pu, Min Zhao, Yan Cheng, Dongmei Yan, Qi Zhao, Zhanxuan E. Wu, Fei Li   +10 more
doaj   +1 more source