Results 41 to 50 of about 404,775 (298)

Genetic polymorphisms of interleukin-10 and transforming growth factor-β1 and antituberculosis drugs-induced liver injury [PDF]

, 2017
Purpose: Drug-induced liver injury is one of the serious adverse reactions resulting in severe morbidity and discontinuation of med ications. Previously, IL-10 gene polymorphism has been reported to be associated with diclofenac-induced hepatitis.
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core   +1 more source

Drug-Induced Liver Injury Induced by Bioflavonoids [PDF]

Cureus, 2021
Drug-induced liver injury (DILI) is a relatively rare disease with a vast spectre of clinical manifestations. Its diagnosis is based on the exclusion of other causes of liver disease. The identification of a causal agent is based on the temporal relation between the symptoms and their resolution after stopping the suspected drug.
Pais, João P, Mota, Rita, Cruz, Mariana, Cambão, Ana R, Nascimento, Ana   +4 more
openaire   +2 more sources

Combined activities of JNK1 and JNK2 in hepatocytes protect against toxic liver injury [PDF]

, 2015
Background & Aims: c-Jun N-terminal kinase (JNK)1 and JNK2 are expressed in hepatocytes and have overlapping and distinct functions. JNK proteins are activated, via phosphorylation, in response to acetaminophen- or CCl4-induced liver damage; the level of
Al Masaoudi, Malika, Bechmann, Lars P., Boekschoten, Mark V., Canbay, Ali E., Cubero, Francisco Javier, Davis, Roger J., Gassler, Nikolaus, Hu, Wei, Liedtke, Christian, Luedde, Tom, Muller, Michael, Nevzorova, Yulia A., Peng, Jin, Preisinger, Christian, Trautwein, Christian, Zhao, Gang, Zoubek, Miguel Eugenio   +16 more
core   +1 more source

The iron-chelating drug M30 down-regulates carbon tetrachloride (CCI4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro [PDF]

, 2013
Topic: 2 Acute Liver FailureThis journal suppl. entitled: APASL Liver Week 2013BACKGROUND/AIMS: The novel multifunctional brain permeable ironchelator M30 possesses neuroprotective activities against several insults applicable to various ...
Fung, ML, Guo, R, Lin, B, Liong, EC, Pan, J, So, KF, Tipoe, GL, Xiao, J, Youdim, M   +8 more
core   +1 more source

Mechanisms of drug induced liver injury. [PDF]

Cell Mol Life Sci
Drug induced liver injury (DILI) is a serious and potentially life-threatening condition resulting from an adverse drug reaction. Both the clinical manifestations and pathological mechanisms of DILI vary depending on drug characteristics, dose, duration of exposure as well as host specific factors.
Skat-Rørdam J, Lykkesfeldt J, Gluud LL, Tveden-Nyborg P.   +3 more
europepmc   +3 more sources

Indigenous Herbal Drug (Tinospora Cordifolia) Induced Liver Injury: A Case Report [PDF]

Bengal Physician Journal
Drug-induced liver injury (DILI) is a condition characterized by acute or chronic liver damage following the use of hepatotoxic drugs. It can be classified based on clinical presentation (hepatocellular, cholestasis, or mixed), mechanism of ...
Sounak Kumar Roy, Muniruddin SK, Subham Mondal, Sandipan Mukherjee, Santa Subhra Chatterjee   +4 more
doaj   +1 more source

Febuxostat-induced acute liver injury [PDF]

, 2016
Febuxostat is a unique xanthine oxidase inhibitor that was approved for the prevention of gout in the United States in 2009. Unlike allopurinol, febuxostat is not a nucleoside analogue and has a higher specificity for xanthine oxidase. Although this drug
Matt Bohm, Naga Chalasani, null null, Raj Vuppalanchi   +3 more
core   +2 more sources

Ayurvedic Drug-Induced Liver Injury

American Journal of Gastroenterology, 2017
Drug induced liver injury is responsible for 50% of acute liver failure in developed countries. Ayurvedic and homeopathic medicine have been linked to liver injury. This case describes the first documented case of Punarnava mandur and Kanchnar guggulu causing drug induced liver injury. Drug induced liver injury may be difficult to diagnosis, but use of
Dalal, Kunal K, Holdbrook, Thomas, Peikin, Steven R   +2 more
openaire   +2 more sources

Impact of Non-Alcoholic Simple Fatty Liver Disease on Antituberculosis Drug-Induced Liver Injury

Infection and Drug Resistance, 2021
Yi-Hui Liu,1 Yan Guo,2 Hong Xu,1 Hui Feng,1 Dong-Ya Chen1 1Department of Digestive Hepatology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, 310003, People’s Republic of China; 2Department of Gastroenterology, Hangzhou Third Hospital, Hangzhou ...
Liu YH, Guo Y, Xu H, Feng H, Chen DY
doaj  

Role of High-Mobility Group Box-1 in Liver Pathogenesis [PDF]

, 2019
High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location.
Huda, Nazmul, Khambu, Bilon, Yan, Shengmin, Yin, Xiao-Ming   +3 more
core   +1 more source