Results 241 to 250 of about 401,429 (294)

Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injury. [PDF]

Mater Today Bio
Gu W, Bai R, Wang J, Wang J, Fang C, Shi Y, Wang P, Wang Q, Bing W, Xie T, Mu J.   +10 more
europepmc   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Autologous Organoid-T Cell Co-Culture Platform for Modeling of Immune-Mediated Drug-Induced Liver Injury. [PDF]

Adv Sci (Weinh)
Soussi FEA, Brusilovsky M, Buck E, Bacon WC, Dadgar S, Fullerton A, Durban VM, Barrile R, Helmrath MA, Takebe T, Roth A, Kasendra M.   +11 more
europepmc   +1 more source

Long‐Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury

Advanced Science, EarlyView.
Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti, Edwige Rice, Franck Desmoulin, Maylis Combeau, Mélissa Parny, Lorenne Robert, Etienne Buscail, Barbara Bournet, Nathalie Vergnolle, Isabelle Raymond‐Letron, Isabelle Loubinoux, Carla Cirillo   +11 more
wiley   +1 more source

Multiscale modeling of drug-induced liver injury from organ to lobule. [PDF]

NPJ Digit Med
Malka-Markovitz A, Camara Dit Pinto S, Cherkaoui M, Levine SM, Anandasabapathy S, Sood GK, Dhingra S, Yujia G, Vierling JM, Gallo NR.   +9 more
europepmc   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

From Therapy to Toxicity: A Rare Case of Acute Piperacillin/Tazobactam-Associated Drug-Induced Liver Injury. [PDF]

Cureus
Maheshwari PK, Maddox A, Yoo J, Harrison A, Fahim P.   +4 more
europepmc   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Computed tomography manifestations of drug-induced liver injury according to type and severity of injury. [PDF]

Quant Imaging Med Surg
Chen Y, Xi Y, Zhao F, Li H, Zhou M, Xu Y, Fan S, Liu M.   +7 more
europepmc   +1 more source

Drug-Induced Liver Injury in Patients With Chronic Liver Disease. [PDF]

Liver Int
Ghabril M, Vuppalanchi R, Chalasani N.
europepmc   +1 more source