Results 261 to 270 of about 401,429 (294)
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Drug Safety, 2007
Drug-induced liver injury is a frequent cause of hepatic dysfunction. Reliably establishing whether the liver disease was caused by a drug requires the exclusion of other plausible causes and the search for a clinical drug signature. The drug signature consists of the pattern of liver test abnormality, the duration of latency to symptomatic ...
Gebran, Abboud, Neil, Kaplowitz
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Drug-induced liver injury is a frequent cause of hepatic dysfunction. Reliably establishing whether the liver disease was caused by a drug requires the exclusion of other plausible causes and the search for a clinical drug signature. The drug signature consists of the pattern of liver test abnormality, the duration of latency to symptomatic ...
Gebran, Abboud, Neil, Kaplowitz
openaire +2 more sources
Drug-Induced Hepatotoxicity or Drug-Induced Liver Injury
Clinics in Liver Disease, 2009Drug-induced hepatotoxicity is underreported and underestimated in the United States. It is an important cause of acute liver failure. Common classes of drugs causing drug-induced hepatotoxicity include antibiotics, lipid lowering agents, oral hypoglycemics, psychotropics, antiretrovirals, acetaminophen, and complementary and alternative medications ...
Aaron J, Pugh +4 more
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Drug-Induced Liver Injury from Antiepileptic Drugs
Clinics in Liver Disease, 2013Drug-induced liver injury is a potential complication of innumerable medications. Most cases do not occur in a predictable, dose-dependent manner, leading to delayed recognition of a drug's hepatotoxic potential until after its release into the market. The estimated occurrence is 1 in 10,000 to 100,000 patients.
Jennifer S, Au, Paul J, Pockros
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Drug rechallenge following drug‐induced liver injury
Hepatology, 2017Drug‐induced hepatocellular injury is identified internationally by alanine aminotransferase (ALT) levels equal to or exceeding 5× the upper limit of normal (ULN) appearing within 3 months of drug initiation, after alternative causes are excluded. Upon withdrawing the suspect drug, ALT generally decrease by 50% or more.
Christine M. Hunt +3 more
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Medicine, 2011
Abstract Drug-induced liver injury (DILI) accounts for 9.5% of all suspected adverse drug reactions (ADRs) and for a significant proportion of fatal ADRs. DILI may be a direct toxic effect or an immunological reaction to either the drug or an active metabolite. Drugs can cause a diverse array of liver injury, which may be acute or chronic.
Adam D. Farmer, Alison Brind
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Abstract Drug-induced liver injury (DILI) accounts for 9.5% of all suspected adverse drug reactions (ADRs) and for a significant proportion of fatal ADRs. DILI may be a direct toxic effect or an immunological reaction to either the drug or an active metabolite. Drugs can cause a diverse array of liver injury, which may be acute or chronic.
Adam D. Farmer, Alison Brind
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1987
The manifold aspects of adverse hepatic drug reactions which have been frequently reviewed (Kaplowitz et al. 1986; Ludwig and Axelsen 1983; Popper et al. 1972; Strieker and Spoelstra 1985; Zimmerman 1978) include (a) pharmacology, based also on the chemical constitution of the drug, (b) mechanistics, dealing with the pathogenesis of the reaction, (c ...
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The manifold aspects of adverse hepatic drug reactions which have been frequently reviewed (Kaplowitz et al. 1986; Ludwig and Axelsen 1983; Popper et al. 1972; Strieker and Spoelstra 1985; Zimmerman 1978) include (a) pharmacology, based also on the chemical constitution of the drug, (b) mechanistics, dealing with the pathogenesis of the reaction, (c ...
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2018
Drug-induced liver injury (DILI) accounts for about 50% of acute liver failure cases in the United States. Diagnosis is challenging, especially due to the myriad combinations of potentially hepatotoxic medications and clinical presentations. Unexplained liver injury should prompt a thorough investigation of medication administration (e.g., for ...
Dennis L. Shung, Joseph K. Lim
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Drug-induced liver injury (DILI) accounts for about 50% of acute liver failure cases in the United States. Diagnosis is challenging, especially due to the myriad combinations of potentially hepatotoxic medications and clinical presentations. Unexplained liver injury should prompt a thorough investigation of medication administration (e.g., for ...
Dennis L. Shung, Joseph K. Lim
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
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