Results 11 to 20 of about 3,896,424 (394)
Drug repurposing for Alzheimer’s disease from 2012–2022—a 10-year literature review
Frontiers in Pharmacology, 2023 Background: Alzheimer’s disease (AD) is a debilitating neurodegenerative condition with few treatment options available. Drug repurposing studies have sought to identify existing drugs that could be repositioned to treat AD; however, the effectiveness of
Monika E. Grabowska +4 more
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Drug repurposing for rare: progress and opportunities for the rare disease community
Frontiers in MedicineRepurposing is one of the key opportunities to address the unmet rare diseases therapeutic need. Based on cases of drug repurposing in small population conditions, and previous work in drug repurposing, we analyzed the most important lessons learned ...
Anneliene Hechtelt Jonker +19 more
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Drug Repurposing as an Effective Drug Discovery Strategy: A Critical Review [PDF]
Drug Design, Development and TherapyAbdulaziz H Al Khzem,1 Saad M Wali2 1Department of Pharmaceutical Chemistry, College of Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Eastern Province, Kingdom of Saudi Arabia; 2Pharmacology and Toxicology Department, College of ...
Al Khzem AH, Wali SM
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How drug repurposing can advance drug discovery: challenges and opportunities
Frontiers in Drug DiscoveryTraditional de novo drug discovery, which typically presents an 11% approval rate from phase I trials and even higher failure rates in fields like neurodegeneration, often requires two to three billion dollars and 10–17 years per new drug.
Luca Pinzi +2 more
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Literature data-based de novo candidates for drug repurposing [PDF]
BMC BioinformaticsBackground Drug repurposing offers a promising strategy for drug discovery. Drug repurposing involves identifying new therapeutic indications for existing, marketed drugs, thereby reducing the risks, costs, and time typically required for drug ...
Xianglong Liang, Xin Jiang, Yifang Ma
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DrugReAlign: a multisource prompt framework for drug repurposing based on large language models
BMC BiologyDrug repurposing is a promising approach in the field of drug discovery owing to its efficiency and cost-effectiveness. Most current drug repurposing models rely on specific datasets for training, which limits their predictive accuracy and scope.
Jinhang Wei +6 more
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Drug repurposing for cancer therapy
Signal Transduction and Targeted TherapyCancer, a complex and multifactorial disease, presents a significant challenge to global health. Despite significant advances in surgical, radiotherapeutic and immunological approaches, which have improved cancer treatment outcomes, drug therapy ...
Ying Xia +3 more
semanticscholar +4 more sources
Does collective consciousness compromise during epidemics and pandemics? [PDF]
EAI Endorsed Transactions on Smart Cities, 2021 The ongoing pandemic, COVID-19, has received unprecedented global attention. Though a pathogen is essentially the causative agent, the dynamics of the cause-effect in major events like the ongoing COVID-19 pandemic is not ...
Anoushka Khanna +3 more
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Editorial: Drug Repurposing [PDF]
Frontiers in Medicine, 2019 Pan Pantziarka +5 more
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Paclitaxel and Therapeutic Drug Monitoring with Microsampling in Clinical Practice
Pharmaceuticals, 2023 Paclitaxel is an anticancer agent efficacious in various tumors. There is large interindividual variability in drug plasma concentrations resulting in a wide variability in observed toxicity in patients.
Mirjana Radovanovic +4 more
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