Results 31 to 40 of about 3,896,424 (394)

COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? [PDF]

, 2020
COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory Syndrome) family.
Auwerx, Blagosklonny, Blagosklonny, Blagosklonny, Colasurdo, Colson, Diaz-Quijano, Du, Erusalimsky, Gerontol, Gorospe, Hoffmann, Häkkinen, Jang, Li, Lisanti, Lisanti, Lu, Masternak, Munster, Musso, Nowakowski, Porter, Subbarao, Subbarao, Tanga, Tremblay, Wilce, Yaron, Yusof, Zhang   +30 more
core   +2 more sources

Considerations and challenges for sex-aware drug repurposing

Biology of Sex Differences, 2022
Highlights Genetic, epigenetic, hormonal, immunological, metabolic, and environmental factors affect sex-biased drug responses. Drug repurposing approaches provide a significant advantage over novel drug development by reducing lengthy and costly ...
Jennifer L. Fisher, Emma F. Jones, Victoria L. Flanary, Avery S. Williams, Elizabeth J. Ramsey, Brittany N. Lasseigne   +5 more
doaj   +1 more source

Network Crosstalk as a Basis for Drug Repurposing

Frontiers in Genetics, 2022
The need for systematic drug repurposing has seen a steady increase over the past decade and may be particularly valuable to quickly remedy unexpected pandemics. The abundance of functional interaction data has allowed mapping of substantial parts of the
Dimitri Guala, Dimitri Guala, Erik L. L. Sonnhammer   +2 more
doaj   +1 more source

Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining [PDF]

Royal Society Open Science, 2018
Drug repurposing aims to find novel indications of clinically used or experimental drugs. Because drug data already exist, drug repurposing may save time and cost, and bypass safety concerns.
Tsang-Pai Liu, Yao-Yu Hsieh, Chia-Jung Chou, Pei-Ming Yang   +3 more
doaj   +1 more source

Drug Repurposing Using Modularity Clustering in Drug-Drug Similarity Networks Based on Drug–Gene Interactions

Pharmaceutics, 2021
Drug repurposing is a valuable alternative to traditional drug design based on the assumption that medicines have multiple functions. Computer-based techniques use ever-growing drug databases to uncover new drug repurposing hints, which require further ...
Vlad Groza, Mihai Udrescu, Alexandru Bozdog, Lucreţia Udrescu   +3 more
doaj   +1 more source

Docking-based virtual screening of known drugs against murE of Mycobacterium tuberculosis towards repurposing for TB. [PDF]

, 2016
Repurposing has gained momentum globally and become an alternative avenue for drug discovery because of its better success rate, and reduced cost, time and issues related to safety than the conventional drug discovery process.
Brindha, Sridharan, Gnanadoss, John Joel, Sundaramurthi, Jagadish Chandrabose, Velmurugan, Devadasan, Vincent, Savariar   +4 more
core   +1 more source

Buying time: Drug repurposing to treat the host in COVID‐19H

Pharmacology Research & Perspectives, 2020
In 2016 Fedson stated …. “For almost two decades, leading scientists and health officials have warned that we must prepare for a potentially devastating global pandemic of an infectious disease. Initial concern was focused on …H5N1….
Jennifer H. Martin, Julian Clark, Richard Head   +2 more
doaj   +1 more source

Synergistic drug combinations from electronic health records and gene expression. [PDF]

, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William, Daugherty, Aaron C, Desai, Manisha, Farrington, Carl, Gomez, Scarlett L, Hastie, Trevor, Kenkare, Pragati, Kurian, Allison W, Lim, Michael, Low, Yen S, Mathur, Maya, Radin, Andrew A, Schroeder, Elizabeth A, Seto, Tina, Shah, Nigam H, Sirota, Marina, Sledge, George W, Thompson, Caroline A, Weber, Susan, Yu, Peter P   +19 more
core   +2 more sources

A phase 1 clinical trial of the repurposable acetyllysine mimetic, n-methyl-2-pyrrolidone (NMP), in relapsed or refractory multiple myeloma

Clinical Epigenetics, 2023
Background N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications including use as a drug-delivery vehicle. Previously considered biologically inert, NMP demonstrates immunomodulatory and
Jake Shortt, Peter Galettis, Chan Y. Cheah, Joanne Davis, Mandy Ludford-Menting, Emma K. Link, Jennifer H. Martin, Rachel Koldej, David Ritchie   +8 more
doaj   +1 more source

Drug Repurposing: Far Beyond New Targets for Old Drugs [PDF]

, 2012
Repurposing drugs requires finding novel therapeutic indications compared to the ones for which they were already approved. This is an increasingly utilized strategy for finding novel medicines, one that capitalizes on previous investments while ...
B Flachner, B Munos, BK Lin, CG Wermuth, CR Chong, D Curley, D Schuster, D Shigemizu, F Briansó, F Prinz, FS Collins, G Steinbach, GMS Silva Da, J Mestres, J Mestres, J Mestres, J. Mestres, JO Yang, K Sanderson, K Seibert, M Campillos, M Cases, MA Lindsay, MJ Keiser, P Cuatrecasas, RF Service, RG Kurumbail, RT Strachan, S Zhao, SH Sleigh, SL Kinnings, T Kawamori, T. I. Oprea, TD Warner, TI Oprea, TI Oprea, TI Oprea, TI Oprea, TT Ashburn, W Weber, WL Lipworth   +40 more
core   +1 more source