Results 31 to 40 of about 3,841,835 (347)

Biomedical knowledge graph learning for drug repurposing by extending guilt-by-association to multiple layers

Nature Communications, 2023
Computational drug repurposing aims to identify new indications for existing drugs by utilizing high-throughput data, often in the form of biomedical knowledge graphs.
D. Bang, Sangsoo Lim, Sangseon Lee, Sun Kim   +3 more
semanticscholar   +1 more source

COVID infection in 4 steps: Thermodynamic considerations reveal how viral mucosal diffusion, target receptor affinity and furin cleavage act in concert to drive the nature and degree of infection in human COVID-19 disease

Heliyon, 2023
We have developed a mechanistic model of SARS-CoV-2 and SARS-CoV infection, exploring the relationship between the viral diffusion in the mucosa and viral affinity for the angiotensin converting enzyme 2 (ACE2) target. Utilising the structural similarity
Marko Popovic, Jennifer H. Martin, Richard J. Head   +2 more
doaj   +1 more source

Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

Nature Genetics, 2023
A multi-ancestry transcriptome-wide association study using an optimal linear combination of association statistics provides insights into tobacco use biology and suggests opportunities for drug repurposing.
Fang Chen, Xingyan Wang, Seonkyeong Jang, Bryan C. Quach, J. D. Weissenkampen, Chachrit Khunsriraksakul, Lina Yang, Renan Sauteraud, C. Albert, Nicholette D D Allred, D. Arnett, A. Ashley-Koch, K. Barnes, R. Barr, D. Becker, L. Bielak, J. Bis, J. Blangero, M. Boorgula, D. Chasman, S. Chavan, Yii-Derr Chen, Lee-Ming Chuang, A. Correa, J. Curran, S. David, L. Fuentes, R. Deka, R. Duggirala, J. Faul, M. Garrett, Sina A. Gharib, Xiuqing Guo, Michael E. Hall, N. Hawley, Jiang He, B. Hobbs, J. Hokanson, C. Hsiung, Shih-Jen Hwang, T. Hyde, M. Irvin, A. Jaffe, E. Johnson, R. Kaplan, S. Kardia, J. Kaufman, T. Kelly, J. Kleinman, C. Kooperberg, I. Lee, D. Levy, S. Lutz, A. Manichaikul, L. Martin, Olivia M Marx, S. McGarvey, R. Minster, M. Moll, Karine A Moussa, T. Naseri, K. North, E. Oelsner, J. Peralta, P. Peyser, B. Psaty, N. Rafaels, L. Raffield, M. Reupena, S. Rich, J. Rotter, D. Schwartz, A. Shadyab, W. Sheu, M. Sims, Jennifer A. Smith, Xiao Sun, K. Taylor, M. Telen, H. Watson, D. Weeks, D. Weir, L. Yanek, K. Young, K. Young, Wei Zhao, D. Hancock, Bibo Jiang, S. Vrieze, Dajiang J. Liu   +89 more
semanticscholar   +1 more source

Drug reprofiling history and potential therapies against Parkinson’s disease

Frontiers in Pharmacology, 2022
Given the high whittling down rates, high costs, and moderate pace of new medication, revelation, and improvement, repurposing “old” drugs to treat typical and uncommon illnesses is progressively becoming an appealing proposition. Drug repurposing is the
Komal Latif, Aman Ullah, Anastasiia D. Shkodina, Anastasiia D. Shkodina, Dmytro I. Boiko, Zakia Rafique, Badrah S. Alghamdi, Badrah S. Alghamdi, Mohamed A. Alfaleh, Mohamed A. Alfaleh, Ghulam Md. Ashraf   +10 more
doaj   +1 more source

Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing

International Journal of Molecular Sciences, 2022
Polycystic ovary syndrome (PCOS) is an endocrine-gynecology disorder affecting many women of childbearing age. Although a part of the involved mechanism in PCOS occurrence is discovered, the exact etiology and pathophysiology are not comprehensively ...
H. Sadeghi, I. Adeli, D. Calina, A. Docea, Taraneh Mousavi, M. Daniali, S. Nikfar, A. Tsatsakis, M. Abdollahi   +8 more
semanticscholar   +1 more source

Repurposing – second life for drugs [PDF]

Pharmacia, 2022
Drug repurposing refers to finding new indications for existing drugs. The paradigm shift from traditional drug discovery to drug repurposing is driven by the fact that new drug pipelines are getting dried up because of mounting Research &amp ...
Porkodi Ayyar, Umamaheswari Subramanian
doaj   +3 more sources

HGTDR: Advancing drug repurposing with heterogeneous graph transformers [PDF]

Bioinformatics
Motivation Drug repurposing is a viable solution for reducing the time and cost associated with drug development. However, thus far, the proposed drug repurposing approaches still need to meet expectations.
Ali Gharizadeh, Karim Abbasi, Amin Ghareyazi, M. R. Mofrad, Hamid R. Rabiee   +4 more
semanticscholar   +1 more source

Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities

Frontiers in Pharmacology, 2023
Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions of Latin America.
Exequiel O. J. Porta, Karunakaran A Kalesh, P. Steel   +2 more
semanticscholar   +1 more source

Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids

Protein & Cell, 2023
Colorectal cancer (CRC) is a highly heterogeneous cancer and exploring novel therapeutic options is a pressing issue that needs to be addressed. Here, we established human CRC tumor-derived organoids that well represent both morphological and molecular ...
Yunuo Mao, Wei Wang, Jingwei Yang, Xiaoxia Zhou, Yongqu Lu, Junpeng Gao, Xiao Wang, Lu Wen, W. Fu, Fuchou Tang   +9 more
semanticscholar   +1 more source

Drug Repurposing in Parkinson’s Disease [PDF]

CNS Drugs, 2018
The development of an intervention to slow or halt disease progression remains the greatest unmet therapeutic need in Parkinson's disease. Given the number of failures of various novel interventions in disease-modifying clinical trials in combination with the ever-increasing costs and lengthy processes for drug development, attention is being turned to
Athauda, D, Foltynie, T
openaire   +3 more sources