Results 41 to 50 of about 3,896,424 (394)

Patient-specific data fusion for cancer stratification and personalised treatment [PDF]

, 2016
According to Cancer Research UK, cancer is a leading cause of death accounting for more than one in four of all deaths in 2011. The recent advances in experimental technologies in cancer research have resulted in the accumulation of large amounts of ...
Gligorijević, V, Malod-Dognin, N, Pržulj, N   +2 more
core   +1 more source

Drug Repurposing: An Effective Tool in Modern Drug Discovery

Russian journal of bioorganic chemistry, 2023
Drug repurposing is using an existing drug for a new treatment that was not indicated before. It has received immense attention during the COVID-19 pandemic emergency.
V. Kulkarni, V. Alagarsamy, V. Solomon, P. Jose, S. Murugesan   +4 more
semanticscholar   +1 more source

In silico and in vitro drug screening identifies new therapeutic approaches for Ewing sarcoma. [PDF]

, 2016
The long-term overall survival of Ewing sarcoma (EWS) patients remains poor; less than 30% of patients with metastatic or recurrent disease survive despite aggressive combinations of chemotherapy, radiation and surgery.
Alturkmani, Hani, Baltezor, Michael, Butte, Atul J, Chen, Bin, Flynn, Colleen A, Godwin, Andrew K, Hyter, Stephen, Ma, Yan, Neville, Kathleen A, Pessetto, Ziyan Y, Rosenthal, Howard G, Weir, Scott J   +11 more
core   +3 more sources

Biomedical knowledge graph learning for drug repurposing by extending guilt-by-association to multiple layers

Nature Communications, 2023
Computational drug repurposing aims to identify new indications for existing drugs by utilizing high-throughput data, often in the form of biomedical knowledge graphs.
D. Bang, Sangsoo Lim, Sangseon Lee, Sun Kim   +3 more
semanticscholar   +1 more source

Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]

, 2020
In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong, Faller, Douglas V., Glavas, Ioannis P., Harpp, David N., Kanara, Iphigenia, Kodukula, Krishna, Mavrakis, Anastasios N., Moos, Walter H., Pernokas, Julie, Pernokas, Mark, Pinkert, Carl A., Powers, Whitney R., Sampani, Konstantina, Steliou, Kosta, Vavvas, Demetrios G., Zamboni, Robert J.   +15 more
core   +1 more source

Drug reprofiling history and potential therapies against Parkinson’s disease

Frontiers in Pharmacology, 2022
Given the high whittling down rates, high costs, and moderate pace of new medication, revelation, and improvement, repurposing “old” drugs to treat typical and uncommon illnesses is progressively becoming an appealing proposition. Drug repurposing is the
Komal Latif, Aman Ullah, Anastasiia D. Shkodina, Anastasiia D. Shkodina, Dmytro I. Boiko, Zakia Rafique, Badrah S. Alghamdi, Badrah S. Alghamdi, Mohamed A. Alfaleh, Mohamed A. Alfaleh, Ghulam Md. Ashraf   +10 more
doaj   +1 more source

Repurposing – second life for drugs [PDF]

Pharmacia, 2022
Drug repurposing refers to finding new indications for existing drugs. The paradigm shift from traditional drug discovery to drug repurposing is driven by the fact that new drug pipelines are getting dried up because of mounting Research &amp ...
Porkodi Ayyar, Umamaheswari Subramanian
doaj   +3 more sources

Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

Nature Genetics, 2023
A multi-ancestry transcriptome-wide association study using an optimal linear combination of association statistics provides insights into tobacco use biology and suggests opportunities for drug repurposing.
Fang Chen, Xingyan Wang, Seonkyeong Jang, B. Quach, J. D. Weissenkampen, Chachrit Khunsriraksakul, Lina Yang, Renan Sauteraud, C. Albert, Nicholette D D Allred, D. Arnett, A. Ashley-Koch, K. Barnes, R. Barr, D. Becker, L. Bielak, J. Bis, J. Blangero, M. Boorgula, D. Chasman, S. Chavan, Yii-Derr Chen, Lee-Ming Chuang, A. Correa, J. Curran, S. David, L. Fuentes, R. Deka, R. Duggirala, J. Faul, M. Garrett, Sina A. Gharib, Xiuqing Guo, Michael E. Hall, N. Hawley, Jiang He, B. Hobbs, J. Hokanson, C. Hsiung, Shih-Jen Hwang, T. Hyde, M. Irvin, A. Jaffe, E. Johnson, R. Kaplan, S. Kardia, J. Kaufman, T. Kelly, J. Kleinman, C. Kooperberg, I. Lee, D. Levy, S. Lutz, A. Manichaikul, L. Martin, Olivia M Marx, S. McGarvey, R. Minster, M. Moll, Karine A Moussa, T. Naseri, K. North, E. Oelsner, J. Peralta, P. Peyser, B. Psaty, N. Rafaels, L. Raffield, M. Reupena, S. Rich, J. Rotter, D. Schwartz, A. Shadyab, W. Sheu, M. Sims, Jennifer A. Smith, Xiao Sun, K. Taylor, M. Telen, H. Watson, D. Weeks, D. Weir, L. Yanek, K. Young, K. Young, Wei Zhao, D. Hancock, Bibo Jiang, S. Vrieze, Dajiang J. Liu   +89 more
semanticscholar   +1 more source

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]

, 2014
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S., Chapman, Melissa S., Galvin, Brendan D., Li, Zhiru, Pollastri, Michael P., Poole, Catherine B., Villemaine, Estelle, Wyatt, Paul G.   +7 more
core   +4 more sources

Repurposing drugs to target nonalcoholic steatohepatitis [PDF]

, 2019
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source