Results 1 to 10 of about 160,273 (298)
Hsp90 governs dispersion and drug resistance of fungal biofilms. [PDF]
PLoS Pathogens, 2011 Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
Nicole Robbins +7 more
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Fungal Drug Response and Antimicrobial Resistance
Journal of Fungi, 2023 Antifungal resistance is a growing concern as it poses a significant threat to public health. Fungal infections are a significant cause of morbidity and mortality, especially in immunocompromised individuals.
Paloma Osset-Trénor +2 more
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Epigenetic Regulation of Antifungal Drug Resistance
Journal of Fungi, 2022 In medical mycology, epigenetic mechanisms are emerging as key regulators of multiple aspects of fungal biology ranging from development, phenotypic and morphological plasticity to antifungal drug resistance.
Sandip Patra +3 more
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Antifungal resistance in dermatophytosis: A global health concern
Letters in Animal Biology, 2022 Dermatophytosis is a common dermatological problem in animals as well as humans which is associated with interference in immune function. Unlike the antibacterial resistance which is frequently reported, antifungal resistance is less commonly reported ...
Jubeda Begum, P Das
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Frontiers in Microbiology, 2022 Drug-resistant fungal infections are emerging as an important clinical problem. In general, antifungal resistance results from increased target expression or mutations within the target protein sequence.
Pengfei Zhai +3 more
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mBio, 2023 Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a link between vesicular trafficking and antifungal resistance.
Juliana Rizzo +16 more
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The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance. [PDF]
PLoS ONE, 2012 The molecular chaperone Hsp90 orchestrates regulatory circuitry governing fungal morphogenesis, biofilm development, drug resistance, and virulence. Hsp90 functions in concert with co-chaperones to regulate stability and activation of client proteins ...
Rebecca S Shapiro +4 more
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mSphere, 2021 Overexpression of the fungal pleiotropic drug resistance (PDR) transporter Cdr1 is a major cause of antifungal drug resistance in Candida ...
Golnoush Madani +2 more
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Microorganisms, 2020 In recent years, the role of mitochondria in pathogenic fungi in terms of azole resistance and fungal pathogenicity has been a rapidly developing field. In this review, we describe the molecular mechanisms by which mitochondria are involved in regulating
Jinxing Song +3 more
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Potential Strategies to Control the Risk of Antifungal Resistance in Humans: A Comprehensive Review
Antibiotics, 2023 Fungal infections are becoming one of the main causes of morbidity and mortality in people with weakened immune systems. Mycoses are becoming more common, despite greater knowledge and better treatment methods, due to the regular emergence of resistance ...
Ali A. Rabaan +19 more
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