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Fungal Drug Response and Antimicrobial Resistance
Journal of Fungi, 2023 Antifungal resistance is a growing concern as it poses a significant threat to public health. Fungal infections are a significant cause of morbidity and mortality, especially in immunocompromised individuals.
Paloma Osset-Trénor +2 more
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Fungal Cell Wall: Emerging Antifungals and Drug Resistance [PDF]
Frontiers in Microbiology, 2019 The cell wall is an essential component in fungal homeostasis. The lack of a covering wall in human cells makes this component an attractive target for antifungal development. The host environment and antifungal stress can lead to cell wall modifications
Soraia L. Lima +2 more
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Microorganisms, 2020 In recent years, the role of mitochondria in pathogenic fungi in terms of azole resistance and fungal pathogenicity has been a rapidly developing field. In this review, we describe the molecular mechanisms by which mitochondria are involved in regulating
Jinxing Song +3 more
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Epigenetic Regulation of Antifungal Drug Resistance
Journal of Fungi, 2022 In medical mycology, epigenetic mechanisms are emerging as key regulators of multiple aspects of fungal biology ranging from development, phenotypic and morphological plasticity to antifungal drug resistance.
Sandip Patra +3 more
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Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens
Biochemical Society Transactions, 2022 Fungal pathogens pose an increasingly worrying threat to human health, food security and ecosystem diversity. To tackle fungal infections and improve current diagnostic and therapeutic tools it is necessary to understand virulence and antifungal drug ...
Miquel Àngel Schikora-Tamarit +1 more
semanticscholar +4 more sources
Antifungals and Drug Resistance
Encyclopedia, 2022 Antifungal drugs prevent topical or invasive fungal infections (mycoses) either by stopping growth of fungi (termed fungistatic) or by killing the fungal cells (termed fungicidal).
Chowdhury Mobaswar Hossain +6 more
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Prevalence of Fungal Drug Resistance in COVID-19 Infection: a Global Meta-analysis
Current Fungal Infection Reports, 2022 Secondary bacterial or fungal infections are one of the most important medical complications among patients with Coronavirus Disease 2019 (COVID-19). The emergence of multidrug-resistant (MDR) candida can cause many problems such as treatment failure ...
Adrina Habibzadeh +9 more
semanticscholar +5 more sources
Nature Communications, 2023 Arastehfar et al. show that macrophage-engulfed cells of fungal pathogen Candida glabrata exhibit multidrug tolerance and increased survival in the presence of cidal antifungal drugs, forming a reservoir from which drug-resistant mutants emerge Candida ...
A. Arastehfar +7 more
semanticscholar +1 more source
Frontiers in Microbiology, 2022 Drug-resistant fungal infections are emerging as an important clinical problem. In general, antifungal resistance results from increased target expression or mutations within the target protein sequence.
Pengfei Zhai +3 more
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mBio, 2023 Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a link between vesicular trafficking and antifungal resistance.
Juliana Rizzo +16 more
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