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Fungal Drug Response and Antimicrobial Resistance

Journal of Fungi, 2023
Antifungal resistance is a growing concern as it poses a significant threat to public health. Fungal infections are a significant cause of morbidity and mortality, especially in immunocompromised individuals.
Paloma Osset-Trénor, Amparo Pascual-Ahuir, Markus Proft   +2 more
doaj   +2 more sources

Mitochondria-Mediated Azole Drug Resistance and Fungal Pathogenicity: Opportunities for Therapeutic Development

Microorganisms, 2020
In recent years, the role of mitochondria in pathogenic fungi in terms of azole resistance and fungal pathogenicity has been a rapidly developing field. In this review, we describe the molecular mechanisms by which mitochondria are involved in regulating
Jinxing Song, Jingwen Zhou, Lei Zhang, Rongpeng Li   +3 more
doaj   +2 more sources

Epigenetic Regulation of Antifungal Drug Resistance

Journal of Fungi, 2022
In medical mycology, epigenetic mechanisms are emerging as key regulators of multiple aspects of fungal biology ranging from development, phenotypic and morphological plasticity to antifungal drug resistance.
Sandip Patra, Mayur Raney, Aditi Pareek, Rupinder Kaur   +3 more
doaj   +2 more sources

Fungal Cell Wall: Emerging Antifungals and Drug Resistance

Frontiers in Microbiology, 2019
The cell wall is an essential component in fungal homeostasis. The lack of a covering wall in human cells makes this component an attractive target for antifungal development. The host environment and antifungal stress can lead to cell wall modifications
Soraia L. Lima, Arnaldo L. Colombo, João N. de Almeida Junior   +2 more
doaj   +2 more sources

Antifungals and Drug Resistance

Encyclopedia, 2022
Antifungal drugs prevent topical or invasive fungal infections (mycoses) either by stopping growth of fungi (termed fungistatic) or by killing the fungal cells (termed fungicidal).
Chowdhury Mobaswar Hossain, Lisa Kathleen Ryan, Meeta Gera, Sabyasachi Choudhuri, Nazmun Lyle, Kazi Asraf Ali, Gill Diamond   +6 more
doaj   +2 more sources

Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance

Nature Communications, 2023
Arastehfar et al. show that macrophage-engulfed cells of fungal pathogen Candida glabrata exhibit multidrug tolerance and increased survival in the presence of cidal antifungal drugs, forming a reservoir from which drug-resistant mutants emerge Candida ...
A. Arastehfar, F. Daneshnia, Nathaly Cabrera, Suyapa Penalva-Lopez, Jansy P. Sarathy, M. Zimmerman, Erika Shor, D. Perlin   +7 more
semanticscholar   +1 more source

Prevalence of Fungal Drug Resistance in COVID-19 Infection: a Global Meta-analysis

Current Fungal Infection Reports, 2022
Secondary bacterial or fungal infections are one of the most important medical complications among patients with Coronavirus Disease 2019 (COVID-19). The emergence of multidrug-resistant (MDR) candida can cause many problems such as treatment failure ...
Adrina Habibzadeh, Kamran B. Lankarani, M. Farjam, M. Akbari, Seyyed Mohammad Amin Kashani, Zeinab Karimimoghadam, Kan Wang, M. Imanieh, R. Tabrizi, F. Ahmadizar   +9 more
semanticscholar   +1 more source

Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens

Biochemical Society Transactions, 2022
Fungal pathogens pose an increasingly worrying threat to human health, food security and ecosystem diversity. To tackle fungal infections and improve current diagnostic and therapeutic tools it is necessary to understand virulence and antifungal drug ...
Miquel Àngel Schikora-Tamarit, T. Gabaldón   +1 more
semanticscholar   +1 more source

Antifungal resistance in dermatophytosis: A global health concern

Letters in Animal Biology, 2022
Dermatophytosis is a common dermatological problem in animals as well as humans which is associated with interference in immune function. Unlike the antibacterial resistance which is frequently reported, antifungal resistance is less commonly reported ...
Jubeda Begum, P Das
doaj   +1 more source

The metal chaperone protein MtmA plays important roles in antifungal drug susceptibility in Aspergillus fumigatus

Frontiers in Microbiology, 2022
Drug-resistant fungal infections are emerging as an important clinical problem. In general, antifungal resistance results from increased target expression or mutations within the target protein sequence.
Pengfei Zhai, Yinyan Ma, Wenlong Du, Ling Lu   +3 more
doaj   +1 more source