Results 11 to 20 of about 613,359 (339)
Fungal Biofilms and Drug Resistance
Emerging Infectious Diseases, 2004 Candida species, including the novel opportunistic pathogen Candida dubliniensis, are now emerging as major agents of nosocomial infections. Many such manifestations of infections associated with the formation of Candida biofilms include those occurring ...
Mary Ann Jabra-Rizk +2 more
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Development and research progress of anti-drug resistant fungal drugs
Journal of Infection and Public Health, 2022 With the widespread use of immunosuppressive agents and the increase in patients with severe infections, the incidence of fungal infections worldwide has increased year by year.
Xiangyi Cui +3 more
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Sphingolipids: Regulators of azole drug resistance and fungal pathogenicity
Molecular Microbiology, 2020 In recent years, the role of sphingolipids in pathogenic fungi, in terms of pathogenicity and resistance to azole drugs, has been a rapidly growing field.
Jinxing Song, Xiao Liu, Rongpeng Li
semanticscholar +3 more sources
Hsp90 governs dispersion and drug resistance of fungal biofilms. [PDF]
PLoS Pathogens, 2011 Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
Nicole Robbins +7 more
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Virulence Regulation and Drug-Resistance Mechanism of Fungal Infection
Microorganisms, 2022 In this issue, I propose promising developments in the field of the mechanism of virulence factors that can be linked to antifungal resistance [...]
Letizia Angiolella
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The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors [PDF]
Frontiers in Microbiology, 2019 CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is also the target of azole drugs in clinical practice.
Jingxiang Zhang +5 more
semanticscholar +4 more sources
Fungal biofilms, drug resistance, and recurrent infection. [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 A biofilm is a surface-associated microbial community. Diverse fungi are capable of biofilm growth. The significance of this growth form for infection biology is that biofilm formation on implanted devices is a major cause of recurrent infection. Biofilms also have limited drug susceptibility, making device-associated infection extremely difficult to ...
Jigar V. Desai, A. Mitchell, D. Andes
semanticscholar +3 more sources
Hsp90 orchestrates stress response signaling governing fungal drug resistance. [PDF]
PLoS Pathogens, 2009 The emergence of drug resistance in microbial pathogens provides a poignant example of an evolutionary process with a profound impact on human health. Fungal drug resistance poses a particular concern given the limited number of clinically useful antifungal drugs and the growing population of immunocompromised individuals vulnerable to life-threatening
Leah E Cowen
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mBio, 2023 Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a link between vesicular trafficking and antifungal resistance.
Juliana Rizzo +16 more
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The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance. [PDF]
PLoS ONE, 2012 The molecular chaperone Hsp90 orchestrates regulatory circuitry governing fungal morphogenesis, biofilm development, drug resistance, and virulence. Hsp90 functions in concert with co-chaperones to regulate stability and activation of client proteins ...
Rebecca S Shapiro +4 more
doaj +1 more source