Results 21 to 30 of about 543,044 (334)
Fungal biofilms, drug resistance, and recurrent infection. [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 A biofilm is a surface-associated microbial community. Diverse fungi are capable of biofilm growth. The significance of this growth form for infection biology is that biofilm formation on implanted devices is a major cause of recurrent infection. Biofilms also have limited drug susceptibility, making device-associated infection extremely difficult to ...
Jigar V. Desai, A. Mitchell, D. Andes
semanticscholar +3 more sources
The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance. [PDF]
PLoS ONE, 2012 The molecular chaperone Hsp90 orchestrates regulatory circuitry governing fungal morphogenesis, biofilm development, drug resistance, and virulence. Hsp90 functions in concert with co-chaperones to regulate stability and activation of client proteins ...
Rebecca S Shapiro +4 more
doaj +1 more source
mSphere, 2021 Overexpression of the fungal pleiotropic drug resistance (PDR) transporter Cdr1 is a major cause of antifungal drug resistance in Candida ...
Golnoush Madani +2 more
doaj +1 more source
Hsp90 orchestrates stress response signaling governing fungal drug resistance. [PDF]
PLoS Pathogens, 2009 The emergence of drug resistance in microbial pathogens provides a poignant example of an evolutionary process with a profound impact on human health. Fungal drug resistance poses a particular concern given the limited number of clinically useful antifungal drugs and the growing population of immunocompromised individuals vulnerable to life-threatening
Leah E Cowen
doaj +5 more sources
Molecular mechanisms governing antifungal drug resistance
npj antimicrobials and resistance, 2023 Fungal pathogens are a severe public health problem. The leading causative agents of systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus genera.
Yunjin Lee, Nicole Robbins, L. Cowen
semanticscholar +1 more source
Potential Strategies to Control the Risk of Antifungal Resistance in Humans: A Comprehensive Review
Antibiotics, 2023 Fungal infections are becoming one of the main causes of morbidity and mortality in people with weakened immune systems. Mycoses are becoming more common, despite greater knowledge and better treatment methods, due to the regular emergence of resistance ...
Ali A. Rabaan +19 more
doaj +1 more source
The Quiet and Underappreciated Rise of Drug-Resistant Invasive Fungal Pathogens [PDF]
Journal of Fungi, 2020 Human fungal pathogens are attributable to a significant economic burden and mortality worldwide. Antifungal treatments, although limited in number, play a pivotal role in decreasing mortality and morbidities posed by invasive fungal infections (IFIs). However, the recent emergence of multidrug-resistant Candida auris and Candida glabrata and acquiring
Amir Arastehfar +7 more
openaire +5 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The incidence of infections due to fungal pathogens has dramatically increased in human populations with weakened or suppressed immune systems.
Asiya Gusa +8 more
semanticscholar +1 more source
Antifungal Drug Resistance: An Emergent Health Threat
Biomedicines, 2023 Fungal infections, named mycosis, can cause severe invasive and systemic diseases that can even lead to death. In recent years, epidemiological data have recorded an increase in cases of severe fungal infections, caused mainly by a growing number of ...
A. Vitiello +8 more
semanticscholar +1 more source
New strategic insights into managing fungal biofilms [PDF]
, 2015 Fungal infections have dramatically increased in the last decades in parallel with an increase of populations with impaired immunity, resulting from medical conditions such as cancer, transplantation or other chronic diseases.
Borghi, Elisa +6 more
core +10 more sources