Results 31 to 40 of about 160,880 (298)

Fungal biofilm resistance [PDF]

, 2012
Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required ...
Rajendran, Ranjith, Ramage, Gordon, Sherry, Leighann, Williams, Craig   +3 more
core   +4 more sources

The Microevolution of Antifungal Drug Resistance in Pathogenic Fungi

Microorganisms, 2023
The mortality rates of invasive fungal infections remain high because of the limited number of antifungal drugs available and antifungal drug resistance, which can rapidly evolve during treatment.
Kylie J. Boyce
doaj   +1 more source

Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. [PDF]

, 2019
Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic
Aller, Altamirano, Arechavala, Bicanic, Bicanic, Boeva, Chang, Chen, Dannaoui, DePristo, Drusano, Harrison, Li, Longley, Loyse, Martin, Mayanja-Kizza, McKenna, Molloy, Mondon, Neely, Nixon, Nussbaum, Saag, Sionov, Sionov, Stone, Stott, Stott, Sudan, Wiederhold, Witt   +31 more
core   +1 more source

Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study [PDF]

, 2013
Background: Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. Objective: To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany ...
Ballus, Jose, Bingold, Tobias Michael, Kaskel, Peter, Krobot, Karl J., Kumar, Ritesh N., Mavros, Panagiotis, Nocea, Gonzalo, Wissing, Heimo   +7 more
core   +1 more source

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates [PDF]

, 2011
The effectiveness of the potent antifungal drug fluconazole is being compromised by the rise of drug-resistant fungal pathogens. While inhibition of Hsp90 or calcineurin can reverse drug resistance in Candida, such inhibitors also impair the homologous ...
Bittker, Joshua A., Buhrlage, Sara J., Dandapani, Sivaraman, Hartland, Cathy L., Johnston, Stephen, Lindquist, Susan, MacPherson, Lawrence, Morgan, Barbara J., Munoz, Benito, Palmer, Michelle, Schreiber, Stuart L., Vincent, Benjamin, Whitesell, Luke, Youngsaye, Willmen   +13 more
core   +1 more source

Coordination of fungal biofilm development by extracellular vesicle cargo

Nature Communications, 2021
The fungal pathogen Candida albicans can release extracellular vesicles that promote biofilm formation and antifungal resistance. Here, Zarnowski et al.
Robert Zarnowski, Andrea Noll, Marc G. Chevrette, Hiram Sanchez, Ryley Jones, Hanna Anhalt, Jen Fossen, Anna Jaromin, Cameron Currie, Jeniel E. Nett, Aaron Mitchell, David R. Andes   +11 more
doaj   +1 more source

Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance

Journal of Infection and Public Health, 2023
In recent years, we are facing the challenge of drug resistance emergence in fungi. The availability of limited antifungals and development of multi-drug resistance in fungal pathogens has become a serious concern in the past years in the health sector ...
Ali A. Rabaan, Khalid Eljaaly, Wadha A. Alfouzan, Abbas Al Mutair, Saad Alhumaid, Amal H. Alfaraj, Yahya Aldawood, Abdulmonem A. Alsaleh, Hawra Albayat, Reyouf Al Azmi, Nawal AlKaabi, Samira J. Alzahrani, Salma AlBahrani, Tarek Sulaiman, Abeer N. Alshukairi, Abdulmonem A. Abuzaid, Mohammed Garout, Rafiq Ahmad, Javed Muhammad   +18 more
doaj   +1 more source

Exploring hidden dimensions of soil fungal biodiversity: A simple technique to detect soil fungi resistant to antifungal compounds [PDF]

, 2010
Soils are known to be ultimate and complex reservoirs of microbial diversity. The complex dimensions of bacterial and fungal diversity in tropical soils and microbial community dynamics are underexplored.
Nandkumar M. Kamat, Sonashia Velho-Pereira   +1 more
core   +2 more sources

Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in Cryptococcus neoformans

mBio, 2016
Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal meningitis in immunocompromised individuals. Treatment options for cryptococcosis are limited.
Wei Huang, Guojian Liao, Gregory M. Baker, Yina Wang, Richard Lau, Padmaja Paderu, David S. Perlin, Chaoyang Xue   +7 more
doaj   +1 more source

Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. [PDF]

PLoS Pathogens, 2012
The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are front-line therapeutics for ...
Sheena D Singh-Babak, Tomas Babak, Stephanie Diezmann, Jessica A Hill, Jinglin Lucy Xie, Ying-Lien Chen, Susan M Poutanen, Robert P Rennie, Joseph Heitman, Leah E Cowen   +9 more
doaj   +1 more source