Antifungal drug-resistance mechanisms in Candida biofilms
Current Opinion in Microbiology, 2022 Infections caused by the Candida species of human fungal pathogens are a significant medical problem because they can disseminate to nearly every organ of the body. In addition, there are only a few classes of antifungal drugs available to treat patients
Jaspreet Kaur, C. Nobile
semanticscholar +1 more source
Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in
mBio, 2016 Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal meningitis in immunocompromised individuals. Treatment options for cryptococcosis are limited.
Wei Huang +7 more
doaj +1 more source
Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. [PDF]
PLoS Pathogens, 2012 The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are front-line therapeutics for ...
Sheena D Singh-Babak +9 more
doaj +1 more source
Quantitative Analysis of Candida Cell Wall Components by Flow Cytometrywith Triple-Fluorescence Staining [PDF]
, 2017 This work was supported by the European Commission within the FP7 Framework Programme [Fungitect-Grant No 602125]. We also thank Thomas Sauer, Vienna Biocenter Campus (VBC), Austria, for technical support at the FACS facility of the MFPL, Karl Kuchler ...
Gow, N +5 more
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Linking calcium signaling and mitochondrial function in fungal drug resistance [PDF]
Proceedings of the National Academy of Sciences, 2020 The host range for Aspergillus fumigatus is wide, including mammals, aves, and insecta (stonebrood). This is linked to the significant adaptability of this important fungal pathogen. It is thermotolerant, able to grow up to 70 °C, and astonishingly also remains viable down to −20 °C (1).
Paul Bowyer +2 more
openaire +3 more sources
Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation [PDF]
, 2017 This work was funded by the UK Biotechnology and Biological Research Council [www.bbsrc.ac.uk] JQ (BB/K016393/1); AJPB (BB/K017365/1). The work was also supported by the Wellcome Trust [www.wellcome.ac.uk], JQ (086048, 097377); AJPB (097377)); LPE ...
Brown, Alistair J P +9 more
core +6 more sources
Antifungal drug resistance: an update
European Journal of Hospital Pharmacy: Science and Practice, 2022 The number of antifungal classes is small, and resistance is becoming a much more frequent problem. Much greater emphasis needs to be placed on susceptibility testing and antifungal stewardship.
D. Denning
semanticscholar +1 more source
New Clox Systems for rapid and efficient gene disruption in Candida albicans [PDF]
, 2014 Acknowledgements: We are grateful to Janet Quinn, Lila Kastora, Joanna Potrykus, Michelle Leach, and others for sharing their experiences with the Clox cassettes.
Ballou, Elizabeth R +6 more
core +7 more sources
Biomédica: revista del Instituto Nacional de Salud, 2023 Introduction. Malassezia is a lipophilic and lipid-dependent yeast genus belonging to the skin microbiota of humans and other animals. However, due to dysbiosis processes or other factors in the host, this yeast can cause different pathologies, ranging ...
Kevin Ehemann +2 more
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The mPEG-PCL Copolymer for Selective Fermentation of Staphylococcus lugdunensis Against Candida parapsilosis in the Human Microbiome. [PDF]
, 2016 Many human skin diseases, such as seborrheic dermatitis, potentially occur due to the over-growth of fungi. It remains a challenge to develop fungicides with a lower risk of generating resistant fungi and non-specifically killing commensal microbes.
Barshop, Bruce A +15 more
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