Results 61 to 70 of about 543,044 (334)

Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease [PDF]

Microbiology and Molecular Biology Reviews, 2011
SUMMARYPathogenic fungi have become a leading cause of human mortality due to the increasing frequency of fungal infections in immunocompromised populations and the limited armamentarium of clinically useful antifungal drugs.Candida albicans,Cryptococcus neoformans, andAspergillus fumigatusare the leading causes of opportunistic fungal infections.
Rebecca S. Shapiro, Nicole Robbins, Leah E. Cowen   +2 more
openaire   +3 more sources

Expression of ERG11, ERG3, MDR1 and CDR1 genes in Candida tropicalis

Biomédica: revista del Instituto Nacional de Salud, 2023
Introduction. Drug resistance to azoles is a growing problem in the Candida genus. Objective. To analyze molecularly the genes responsible for fluconazole resistance in Candida tropicalis strains. Materials and methods. Nineteen strains, with and without
Ana Elisa Rojas, Leidy Yurany Cárdenas, María Camila García, Jorge Enrique Pérez   +3 more
doaj   +1 more source

Candidemia: Evolution of Drug Resistance and Novel Therapeutic Approaches

Infection and Drug Resistance, 2021
Candidemia and invasive candidiasis are the most common healthcare-associated invasive fungal infections, with a crude mortality rate of 25–50%. Candida albicans remains the most frequent etiology, followed by C. glabrata, C.
A. Tortorano, A. Prigitano, G. Morroni, L. Brescini, F. Barchiesi   +4 more
semanticscholar   +1 more source

mSphere of Influence: Rapid evolution of pathogenesis and drug resistance in human pathogenic fungi

mSphere
Pengjie Hu works in the field of fungal pathogenesis, drug resistance, and evolution. In this mSphere of Influence article, he reflects on how three works, “Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection ...
Pengjie Hu
doaj   +1 more source

Finding the needle in a haystack: Mapping antifungal drug resistance in fungal pathogen by genomic approaches

PLoS Pathogens, 2019
Fungi are ubiquitous on earth and are essential for the maintenance of the global ecological equilibrium. Despite providing benefits to living organisms, they can also target specific hosts and inflict damage.
D. Sanglard
semanticscholar   +1 more source

The Fungal Cell Wall : Structure, Biosynthesis, and Function [PDF]

, 2017
N.G. is funded by the Wellcome Trust via a senior investigator award and a strategic award and by the MRC Centre for Medical Mycology. C.M. acknowledges the support of the Wellcome Trust and the MRC. N.G. and C.M.
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core   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis

PLoS Genetics, 2016
Fungal pathogens have evolved diverse strategies to sense host-relevant cues and coordinate cellular responses, which enable virulence and drug resistance.
Elizabeth J. Polvi, A. Averette, Soo Chan Lee, Taeyup Kim, Yong-Sun Bahn, Amanda O. Veri, Nicole Robbins, J. Heitman, L. Cowen   +8 more
semanticscholar   +1 more source

Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis

Frontiers in Cellular and Infection Microbiology, 2021
Candida species are the leading cause of invasive fungal infections worldwide and are associated with acute mortality rates of ~50%. Mortality rates are further augmented in the context of host immunosuppression and infection with drug-resistant Candida ...
Sarah E. Murphy, T. Bicanic
semanticscholar   +1 more source

Vaginal yeasts in the era of "over the counter" antifungals [PDF]

, 2000
OBJECTIVE: To establish whether there has been any rise in the prevalence of non-albicans Candida species isolated from vaginal swabs since the introduction of “over the counter” antifungal treatments.
Ashbee, H.R., Brown, C., Evans, E.G.V., Reynolds, M.T., Walker, P.P.   +4 more
core   +2 more sources