Results 71 to 80 of about 160,880 (298)
Flipping and other astonishing transporter dance moves in fungal drug resistance
BioEssays, 2022 AbstractIn all domains of life, transmembrane proteins from the ATP‐binding cassette (ABC) transporter family drive the translocation of diverse substances across lipid bilayers. In pathogenic fungi, the ABC transporters of the pleiotropic drug resistance (PDR) subfamily confer antibiotic resistance and so are of interest as therapeutic targets.
Raschka, Stefanie L +3 more
openaire +2 more sources
Advanced Functional Materials, EarlyView.Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou +11 more
wiley +1 more source
Lysine Deacetylases Hda1 and Rpd3 Regulate Hsp90 Function thereby Governing Fungal Drug Resistance
Cell Reports, 2012 The molecular chaperone Hsp90 is a hub of protein homeostasis and regulatory circuitry. Hsp90 function is regulated by posttranslational modifications including acetylation in mammals; however, whether this regulation is conserved remains unknown.
Nicole Robbins +2 more
doaj +1 more source
A reverse chemical ecology approach to explore wood natural durability [PDF]
, 2020 The natural durability of wood species, defined as their inherent resistance to wood‐destroying agents, is a complex phenomenon depending on many biotic and abiotic factors.
Beauchène J. +11 more
core +3 more sources
Advanced Functional Materials, EarlyView.Polyferrocene block copolymers are synthesized and assembled into micron‐sized polymer cubosomes with double diamond lattice and pore diameter of ≈30 nm. The ferrocene functionality is retained within the polymer cubosome wall as demonstrated on supramolecular modification, and oxidative disassembly.
Chin Ken Wong +4 more
wiley +1 more source
Indian Journal of Community Medicine, 2019 Background: It is well documented in the literature that fungal infections are common in diabetic foot ulcers (DFUs). This has led to an overuse of antifungal agents, namely fluconazole, with a consequent risk of emergence of resistance to this drug ...
Chankramath S Arun +5 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.As implantable medical devices become indispensable to modern medicine, a silent threat grows alongside them: device‐associated infections. Despite decades of antibiotic innovation, infection rates keep climbing, costing lives and billions in healthcare expenses.
Benito Baldauf +5 more
wiley +1 more source
The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors [PDF]
Frontiers in Microbiology, 2019 CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is also the target of azole drugs in clinical practice. In recent years, researches on fungal CYP51 have stepped into a new stage attributing to the discovery of crystal ...
Jingxiang Zhang +8 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales +11 more
wiley +1 more source
Nanoemulsion as an Effective Treatment against Human-Pathogenic Fungi
mSphere, 2019 Infections triggered by pathogenic fungi cause a serious threat to the public health care system. In particular, an increase of antifungal drug-resistant fungi has resulted in difficulty in treatment.
Alexis Garcia +6 more
doaj +1 more source