Results 71 to 80 of about 2,071,500 (370)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Metabolic signature identifies novel targets for drug resistance in multiple myeloma.

Cancer Research, 2015
Drug resistance remains a major clinical challenge for cancer treatment. Multiple myeloma is an incurable plasma cell cancer selectively localized in the bone marrow.
P. Maiso, D. Huynh, M. Moschetta, A. Sacco, Y. Aljawai, Y. Mishima, J. Asara, A. Roccaro, Alec C. Kimmelman, I. Ghobrial   +9 more
semanticscholar   +1 more source

EMT‐associated microRNAs and their roles in cancer stemness and drug resistance

Cancer Communications, 2021
Epithelial‐to‐mesenchymal transition (EMT) is implicated in a wide array of malignant behaviors of cancers, including proliferation, invasion, and metastasis.
G. Pan, Yuhan Liu, Luorui Shang, Fangyuan Zhou, Shenglan Yang   +4 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Increased expression of a microRNA correlates with anthelmintic resistance in parasitic nematodes [PDF]

, 2017
Resistance to anthelmintic drugs is a major problem in the global fight against parasitic nematodes infecting humans and animals. While previous studies have identified mutations in drug target genes in resistant parasites, changes in the expression ...
Bartley, David, Britton, Collette, Devaney, Eileen, Gillan, Victoria, Gilleard, John S., Gu, Henry, Laing, Roz, Maitland, Kirsty, Marks, Neil D., Martinelli, Axel, Morrison, Alison, Rezansoff, Andrew M., Skuce, Philip J., Winter, Alan D.   +13 more
core   +2 more sources

Prospect for application of mathematical models in combination cancer treatments [PDF]

arXiv, 2020
The long-term efficacy of targeted therapeutics for cancer treatment can be significantly limited by the type of therapy and development of drug resistance, inter alia. Experimental studies indicate that the factors enhancing acquisition of drug resistance in cancer cells include cell heterogeneity, drug target alteration, drug inactivation, DNA damage
arxiv  

RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma

Leukemia, 2017
Multiple myeloma (MM) is a plasma cell cancer with poor survival, characterized by the expansion of multiple myeloma cells (MMCs) in the bone marrow.
E. Viziteu, B. Klein, J. Basbous, Yea-Lih Lin, C. Hirtz, C. Gourzonès, L. Tiers, A. Bruyer, L. Vincent, C. Grandmougin, A. Seckinger, H. Goldschmidt, A. Constantinou, P. Pasero, D. Hose, J. Moreaux   +15 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Significant geographical differences in prevalence of mutations associated with Plasmodium falciparum and Plasmodium vivax drug resistance in two regions from Papua New Guinea [PDF]

, 2015
Drug resistance remains a major obstacle to malaria treatment and control. It can arise and spread rapidly, and vary substantially even at sub-national level.
Barnadas, Céline, Davis, Timothy M., Iga, Jonah, Javati, Sarah, Karunajeewa, Harin, Kiniboro, Benson, Koepfli, Cristian, Malau, Elisheba, Mueller, Ivo, Rare, Lawrence, Reeder, John C., Robinson, Leanne J., Senn, Nicolas, Siba, Peter M., Timinao, Lincoln, Zimmerman, Peter A.   +15 more
core   +3 more sources

Left-Sided Endocarditis Associated with Multi-Drug Resistance Acinetobacter Lwoffii [PDF]

Journal of Tehran University Heart Center, 2009
Acinetobacter lwoffii, an important nosocomial pathogen, is a gram-negative aerobic bacillus that is a component of the normal flora on the skin, oropharynx, and perineum of about 20-25% of healthy individuals.
Hossein Ahmadi, Mohammad Ali Boroumand, Maryam Sotoudeh Anvari, Abbasali Karimi, Naghmeh Moshtaghi   +4 more
doaj   +1 more source