Results 81 to 90 of about 2,071,500 (370)
Intra-Vesical Colistin for Pseudomonas aeruginosa Urinary Tract Infections
European Journal of Case Reports in Internal Medicine, 2019 The numbers of multiple drug-resistant Gram-negative bacterial infections are rising worldwide. The threat is increased by the lack of new antibiotics, so clinicians are turning to older drugs previously abandoned due to their recognized toxicity, such ...
Rui Encarnado Assis +6 more
doaj +1 more source
Simultaneous prediction of multiple outcomes using revised stacking algorithms [PDF]
, 2019 Motivation: HIV is difficult to treat because its virus mutates at a high rate and mutated viruses easily develop resistance to existing drugs. If the relationships between mutations and drug resistances can be determined from historical data, patients can be provided personalized treatment according to their own mutation information.
arxiv +1 more source
Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance
Frontiers in Pharmacology, 2021 Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad spectrum of structurally and mechanistically unrelated drugs across membranes, severely impairs the response to chemotherapy and leads to chemotherapy failure ...
Huan Xiao +4 more
semanticscholar +1 more source
Biomarkers and Multiple Drug Resistance in Breast Cancer [PDF]
Current Cancer Drug Targets, 2006 Breast cancer, the most common form of cancer among women in North America and almost all of Europe, is a significant health problem in terms of both morbidity and mortality. It is estimated that each year this disease is diagnosed in over one million people worldwide and is the cause of more than 400,000 deaths.
Lorraine O'Driscoll, Martin Clynes
openaire +4 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype [PDF]
, 2016 Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range of cancers. Indeed, aberrant activation of the Hh pathway occurring either by ligand-dependent or -independent mechanisms is a key driver in tumorigenesis.
Alfonsi, Romina +13 more
core +1 more source
Паёми Сино, 2018 Objective: To assess the epidemic situation in the Russian Federation on tuberculosis with multidrug-resistant and extensively drug-resistant (MDR, XDR) of the pathogen and the effectiveness of its treatment.
A.E. ERGESHOV +5 more
doaj +1 more source
Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma.
Journal of Clinical Investigation, 2015 Alterations in chromatin modifications, such as histone methylation, have been suggested as mediating chemotherapy resistance in several cancer types; therefore, elucidation of the epigenetic mechanisms that underlie drug resistance may greatly ...
J. Kikuchi +6 more
semanticscholar +1 more source
Drug resistance and Cancer stem cells
Cell Communication and Signaling, 2021 Therapy resistance is a major problem when treating cancer patients as cancer cells develop mechanisms that counteract the effect of therapeutic compounds, leading to fit and more aggressive clones that contribute to poor prognosis.
Yuan Li +3 more
semanticscholar +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source