Results 41 to 50 of about 1,143,151 (266)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The integrated analysis of SIRT family expression, prognostic value, and potential implications in childhood acute lymphoblastic leukemia

Frontiers in Oncology
BackgroundAcute lymphoblastic leukemia (ALL) is a rapidly progressive hematological malignancy caused by the dysregulated proliferation and abnormal differentiation or differentiation block of lymphoid precursors.
Xusan Xu, Zhendong Wang, Xiaoxia Wang, Wensen Zhang, Zhengqiang Luo, Xiaomei Zheng, Ronghua Pan, Ying Fu, Yajun Wang, Guochun Huang, Riling Chen, Guoda Ma   +11 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Targeted and personalized immunotherapy in lung adenocarcinoma: single-cell RNA sequencing of MAFF+ tumor cells and the therapeutic potential of FOS

Frontiers in Immunology
BackgroundNon-small cell lung cancer (NSCLC) was a major cause of cancer-related mortality globally. Despite advancements in immunotherapy and targeted therapies, clinical outcomes were still limited by tumor heterogeneity and treatment resistance.
Xiangsong Cheng, Shu Chen, Yilong Fu, Runze Jiang, Yanlong Jing, Bizhu Zhao, Dong Guo, Liangyu Wang, Zi Ye, Yumeng Li, Xianliang Chen   +10 more
doaj   +1 more source

Inducible Co-Stimulator ICOS Expression Correlates with Immune Cell Infiltration and Can Predict Prognosis in Lung Adenocarcinoma

International Journal of General Medicine, 2022
Gujie Wu,1,* Min He,1,* Kuan Ren,1,* Huiyun Ma,1 Qun Xue2 1Medical School of Nantong University, Nantong, People’s Republic of China; 2Cardiothoracic Surgery Department, Affiliated Hospital of Nantong University, Nantong, People’s Republic of
Wu G, He M, Ren K, Ma H, Xue Q
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effects of physiological levels of the green tea extract Epigallocatechin gallate (EGCG) on breast cancer cells

Frontiers in Endocrinology, 2014
Physiological concentrations of the green tea extract EGCG caused growth inhibition in oestrogen receptor α (ERα)-positive MCF7 cells, that was associated with down-regulation of the ERα and reduced insulin-like growth factor (IGF) binding protein-2 ...
Li eZeng, Jeff M P Holly, Claire ePerks
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A mitochondrial ferroptosis-related gene signature predicts prognosis and immune landscape in colon cancer

Frontiers in Medicine
BackgroundColon cancer is a highly aggressive gastrointestinal malignancy with significant global health implications. Although mitochondrial ferroptosis-related genes have been implicated in colon cancer progression, their prognostic significance ...
Hou Wang, Hou Wang, Hou Wang
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source