Results 41 to 50 of about 4,681,502 (208)

The integrated analysis of SIRT family expression, prognostic value, and potential implications in childhood acute lymphoblastic leukemia

Frontiers in Oncology
BackgroundAcute lymphoblastic leukemia (ALL) is a rapidly progressive hematological malignancy caused by the dysregulated proliferation and abnormal differentiation or differentiation block of lymphoid precursors.
Xusan Xu, Zhendong Wang, Xiaoxia Wang, Wensen Zhang, Zhengqiang Luo, Xiaomei Zheng, Ronghua Pan, Ying Fu, Yajun Wang, Guochun Huang, Riling Chen, Guoda Ma   +11 more
doaj   +1 more source

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
Sylke Müller, Hideo Imamura (62469), Dujardin, J., Khanal, Basudha, Brunker, K., Brunker, Kirstyn, Kirstyn Brunker (181178), Graham H. Coombs (164011), Suman Rijal (181185), Imamura, Hideo, Jean-Claude Dujardin, M\ufcller, Sylke, Dujardin, Jean-Claude, Dujardin, J. C., Coombs, G. H., Muller, S., Jean-Claude Dujardin (56958), Decuypere, S., Coombs, G.H., Vanaerschot, M., Decuypere, Saskia, Coombs, Graham H, Rijal, S., Manu Vanaerschot, Sylke Müller (37476), Basudha Khanal, Khanal, B., Hideo Imamura, Kirstyn Brunker, Müller, Sylke, Coombs, Graham H., Vanaerschot, Manu, Imamura, H., Rijal, Suman, Saskia Decuypere, Basudha Khanal (181181), Saskia Decuypere (181176), Manu Vanaerschot (109210), Suman Rijal, Graham H Coombs   +39 more
core   +4 more sources

Targeted and personalized immunotherapy in lung adenocarcinoma: single-cell RNA sequencing of MAFF+ tumor cells and the therapeutic potential of FOS

Frontiers in Immunology
BackgroundNon-small cell lung cancer (NSCLC) was a major cause of cancer-related mortality globally. Despite advancements in immunotherapy and targeted therapies, clinical outcomes were still limited by tumor heterogeneity and treatment resistance.
Xiangsong Cheng, Shu Chen, Yilong Fu, Runze Jiang, Yanlong Jing, Bizhu Zhao, Dong Guo, Liangyu Wang, Zi Ye, Yumeng Li, Xianliang Chen   +10 more
doaj   +1 more source

Inducible Co-Stimulator ICOS Expression Correlates with Immune Cell Infiltration and Can Predict Prognosis in Lung Adenocarcinoma

International Journal of General Medicine, 2022
Gujie Wu,1,* Min He,1,* Kuan Ren,1,* Huiyun Ma,1 Qun Xue2 1Medical School of Nantong University, Nantong, People’s Republic of China; 2Cardiothoracic Surgery Department, Affiliated Hospital of Nantong University, Nantong, People’s Republic of
Wu G, He M, Ren K, Ma H, Xue Q
doaj  

Effects of physiological levels of the green tea extract Epigallocatechin gallate (EGCG) on breast cancer cells

Frontiers in Endocrinology, 2014
Physiological concentrations of the green tea extract EGCG caused growth inhibition in oestrogen receptor α (ERα)-positive MCF7 cells, that was associated with down-regulation of the ERα and reduced insulin-like growth factor (IGF) binding protein-2 ...
Li eZeng, Jeff M P Holly, Claire ePerks
doaj   +1 more source

A mitochondrial ferroptosis-related gene signature predicts prognosis and immune landscape in colon cancer

Frontiers in Medicine
BackgroundColon cancer is a highly aggressive gastrointestinal malignancy with significant global health implications. Although mitochondrial ferroptosis-related genes have been implicated in colon cancer progression, their prognostic significance ...
Hou Wang, Hou Wang, Hou Wang
doaj   +1 more source

Western Hemisphere Drug Policy Commission [website]

, 2021
Website of the Western Hemisphere Drug Policy Commission (WHDPC), charged to "evaluate a range of US counternarcotics programs in the Americas and then make recommendations to improve them" -- including a recording and transcript of the group's hearing ...
United States. Western Hemisphere Drug Policy Commission.
core  

Knowledge among Drug Dispensers and Antimalarial Drug Prescribing Practices in Public Health Facilities in Dar es Salaam. [PDF]

, 2013
Irrational prescribing and dispensing of antimalarials has been identified as a contributing factor in the emergence of malaria parasites resistant to existing antimalarial drugs.
Kamuhabwa AA, Silumbe R, Kamuhabwa, Appolinary Ar, Silumbe, Richard   +3 more
core   +1 more source

YRDC is a Prognostic‐Related Biomarker Correlated With Immune Infiltration and Drug Sensitivity in Pan‐Cancer

Cancer Reports
Background YRDC has emerged as a potential biomarker in cancer, yet its prognostic value, oncogenic mechanisms, role in immune infiltration, and anticancer drugs efficacy in pan‐cancer remained poorly understood.
Li Qiao, Yuetong Zhang, Pin Huang
doaj   +1 more source

Acute Myeloid Leukemia: A Key Role of DGKα and DGKζ in Cell Viability

Cells
Acute myeloid leukemia (AML) is a heterogeneous disease with an unmet need for novel therapeutic drugs. Previous studies have reported the upregulation of diacylglycerol kinases (DGKs) in AML.
Elisa Gorla, Marco Cristiano Cartella, Edoardo Borghetti, Ginevra Lovati, Luisa Racca, Teresa Gravina, Giorgio Biazzo, Gabriele Bonello, Valeria Malacarne, Veronica De Giorgis, Davide Corà, Marcello Manfredi, Alberto Massarotti, Andrea Graziani, Gianluca Baldanzi   +14 more
doaj   +1 more source