Results 31 to 40 of about 4,681,502 (208)

Culture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markers. [PDF]

, 2013
BACKGROUND: The screening of lead compounds against in vitro parasite cultures is an essential step in the development of novel anti-malarial drugs, but currently relies on laboratory parasite lines established in vitro during the last century.
Sutherland, CJ, van Schalkwyk, DA, Wright, Stephen G, Henriques, G, Burrow, Rebekah, Beshir, Khalid B, Beshir, KB, Hasford, Christian, Hasford, C, Ding, XC, Gadalla, Nahla B, Chiodini, Peter L, Sutherland, Colin J, van Schalkwyk, Donelly A, Henriques, Gisela, Gadalla, NB, Wright, SG, Ding, Xavier C, Chiodini, PL   +18 more
core   +1 more source

Synergistic effects of 5-fluorouracil in combination with salinomycin promoted ferroptosis via inhibiting SLC7A11/GPX4 in colorectal cancer

Frontiers in Oncology
Purpose5-Fluorouracil (5-FU) resistance is considered to be a possible reason for the failure of conventional drug treatment of colorectal cancer (CRC).
Can Wang, Junyang Wang, Fei Xing, Ning Liu, Xudong Wang   +4 more
doaj   +1 more source

Development of an in vitro drug sensitivity assay based on newly excysted larvae of Echinostoma caproni [PDF]

, 2013
Echinostomiasis is one of the major food-borne trematodiases and the species Echinostoma caproni serves as a useful model for trematocidal drug discovery. The current in vitro drug sensitivity assay uses adult E.
Gordana Panic, Katrin Ingram, Jennifer Keiser, Keiser, Jennifer, Ingram, Katrin, Panic, Gordana   +5 more
core   +1 more source

A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma

Frontiers in Pharmacology
ObjectiveOsteosarcoma is the most common primary bone cancer with a high propensity for local invasion and metastasis. An increasing number of research studies show that telomeres play an important role in the occurrence and development of cancer.
Shihao Li, Lina Zhang, Haiyang Zhang
doaj   +1 more source

Fluorescence/luminescence-based markers for the assessment of Schistosoma mansoni schistosomula drug assays [PDF]

, 2015
Schistosomiasis is responsible for a tremendous public health burden, yet only a single drug, praziquantel, is available. New antischistosomal treatments should therefore be developed. The accuracy, speed and objectivity of in vitro drug screening depend
Gordana Panic, Jennifer Keiser, Flores, Dayana, Keiser, Jennifer, Ingram-Sieber, Katrin, Dayana Flores, Katrin Ingram-Sieber, Panic, Gordana   +7 more
core   +1 more source

Isolation, Identification and Drug Sensitivity Analysis of a Strain of Streptococcus agalactiae in Tilapia (Oreochromis niloticus) from Goose-fish Polyculture Environment

Guangdong nongye kexue
【Objective】In order to identify the pathogenic bacteria causing the tilapia disease outbreak in the geese-fish polyculture system, the growth characteristics, pathogenicity and drug sensitivity of the pathogenic bacteria were analyzed, with an aim to ...
Jinfeng MO, Meng ZHOU, Guozhang LI, Yifan NIE, Jianmin YE, Zaohe WU   +5 more
doaj   +1 more source

Exosomal microRNAs in breast cancer: towards theranostic applications

Frontiers in Molecular Biosciences
Breast cancer is one of the top two reproductive cancers responsible for high rates of morbidity and mortality among women globally. Despite the advancements in the treatment of breast cancer, its early diagnosis remains a challenge.
Richa Gulati, Tridip Mitra, Rohan Rajiv, Emilda Judith Ezhil Rajan, Chris Pierret, Elizabeth Ann L. Enninga, Rajiv Janardhanan   +6 more
doaj   +1 more source

Quantifying Glioblastoma Drug Response Dynamics Incorporating Treatment Sensitivity and Blood Brain Barrier Penetrance From Experimental Data

Frontiers in Physiology, 2020
Many drugs investigated for the treatment of glioblastoma (GBM) have had disappointing clinical trial results. Efficacy of these agents is dependent on adequate delivery to sensitive tumor cell populations, which is limited by the blood-brain barrier ...
Susan Christine Massey, Javier C. Urcuyo, Bianca Maria Marin, Jann N. Sarkaria, Kristin R. Swanson, Kristin R. Swanson, Kristin R. Swanson   +6 more
doaj   +1 more source

Evaluation of the Peer Support Program (Student Drug Prevention) 1986-1987

, 2019
The Peer Support program is a school based program funded by the National Campaign Against Drug Abuse (NCADA) as a drug prevention strategy. Prior to the existence of the NCADA the program was funded through the NSW Drug and Alcohol Authority.
Directorate of the Drug Offensive
core   +1 more source

Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma

Frontiers in Oncology
Hepatocellular carcinoma (HCC) is one of the most common lethal cancers worldwide. Natural killer cells (NK cells) play a key role in liver immunosurveillance, but in the tumor microenvironment, NK cells are readily depleted, as evidenced by down ...
Yuxiang Huang, Hengjian Liao, Jiefu Luo, Huaning Wei, Anling Li, Yujie Lu, Bangde Xiang   +6 more
doaj   +1 more source