Results 11 to 20 of about 1,143,151 (266)

Molecular Characterization and Clinical Relevance of ALDH2 in Human Cancers

Frontiers in Medicine, 2022
Background: Aldehyde dehydrogenase 2 (ALDH2) is well-known to be a key enzyme in alcohol metabolism. However, a comprehensive understanding of ALDH2 across human cancers is lacking.Methods: A systematic and comprehensive analysis of the molecular ...
Bo Ma, Zaoqu Liu, Zaoqu Liu, Zaoqu Liu, Hui Xu, Hui Xu, Hui Xu, Long Liu, Tao Huang, Lingfang Meng, Libo Wang, Yuyuan Zhang, Lifeng Li, Xinwei Han, Xinwei Han, Xinwei Han   +15 more
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Immune-Related lncRNA Pairs as Prognostic Signature and Immune-Landscape Predictor in Lung Adenocarcinoma

Frontiers in Oncology, 2022
BackgroundSuppressive tumor microenvironment is closely related to the progression and poor prognosis of lung adenocarcinoma (LUAD). Novel individual and universal immune-related biomarkers to predict the prognosis and immune landscape of LUAD patients ...
Zhengrong Yin, Mei Zhou, Tingting Liao, Juanjuan Xu, Jinshuo Fan, Jingjing Deng, Yang Jin   +6 more
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Integrated bioinformatical analysis, machine learning and in vitro experiment-identified m6A subtype, and predictive drug target signatures for diagnosing renal fibrosis

Frontiers in Pharmacology, 2022
Renal biopsy is the gold standard for defining renal fibrosis which causes calcium deposits in the kidneys. Persistent calcium deposition leads to kidney inflammation, cell necrosis, and is related to serious kidney diseases.
Chunxiang Feng, Zhixian Wang, Zhixian Wang, Chang Liu, Shiliang Liu, Yuxi Wang, Yuanyuan Zeng, Qianqian Wang, Tianming Peng, Xiaoyong Pu, Jiumin Liu   +10 more
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A Metabolism-Related Gene Landscape Predicts Prostate Cancer Recurrence and Treatment Response

Frontiers in Immunology, 2022
BackgroundProstate cancer (PCa) is the most common malignant tumor in men. Although clinical treatments of PCa have made great progress in recent decades, once tolerance to treatments occurs, the disease progresses rapidly after recurrence.
Lijie Zhou, Lijie Zhou, Ruixin Fan, Ruixin Fan, Yongbo Luo, Yongbo Luo, Cai Zhang, Donghui Jia, Rongli Wang, Youmiao Zeng, Youmiao Zeng, Mengda Ren, Mengda Ren, Kaixuan Du, Kaixuan Du, Wenbang Pan, Wenbang Pan, Jinjian Yang, Jinjian Yang, Fengyan Tian, Chaohui Gu, Chaohui Gu   +21 more
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Establishment and external verification of an oxidative stress-related gene signature to predict clinical outcomes and therapeutic responses of colorectal cancer

Frontiers in Pharmacology, 2023
Objective: Accumulated evidence highlights the biological significance of oxidative stress in tumorigenicity and progression of colorectal cancer (CRC).
Sha Cao, Cheng Chen, Dezhi Gu, Zhengdong Wang, Guanghui Xu   +4 more
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Identification and validation of a novel cuproptosis-related genes signature associated with prognosis, clinical implications and immunotherapy of hepatocellular carcinoma

Frontiers in Pharmacology, 2023
Background: Cuproptosis is a novel type of regulated cell death and is reported to promote tumor occurrence and progression. However, whether a cuproptosis-related signature has an impact on hepatocellular carcinoma (HCC) is still unclear.Materials and ...
Fengjiao He, Fengjiao He, Fengjiao He, Puhua Zeng, Sijing Ma, Ximing Yang, Huan Liu, Huan Liu, Qiong Liu, Qiong Liu, Yangying Zhou, Yangying Zhou, Hong Zhu, Hong Zhu   +13 more
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A novel prognostic gene set for colon adenocarcinoma relative to the tumor microenvironment, chemotherapy, and immune therapy

Frontiers in Genetics, 2023
Background: Colon adenocarcinoma (COAD) is a common aggressive malignant tumor. Heterogeneity in tumorigenesis and therapy response leads to an unsatisfactory overall survival of colon adenocarcinoma patients.
Hui Zhou, Yongxiang Wang, Zijian Zhang, Li Xiong, Zhongtao Liu, Yu Wen   +5 more
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Subtypes analysis and prognostic model construction based on lysosome-related genes in colon adenocarcinoma

Frontiers in Genetics, 2023
Background: Lysosomes are essential for the development and recurrence of cancer. The relationship between a single lysosome-related gene and cancer has previously been studied, but the relationship between the lysosome-related genes (LRGs) and colon ...
Yang Chen, Yang Chen, Yunfei Lu, Yunfei Lu, Changzhi Huang, Changzhi Huang, Jingyu Wu, Jingyu Wu, Yu Shao, Yu Shao, Zhenling Wang, Zhenling Wang, Hongqiang Zhang, Hongqiang Zhang, Zan Fu, Zan Fu   +15 more
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The Pan-Cancer Crosstalk Between the EFNA Family and Tumor Microenvironment for Prognosis and Immunotherapy of Gastric Cancer

Frontiers in Cell and Developmental Biology, 2022
Background:EFNA1–5 have important physiological functions in regulating tumorigenesis and metastasis. However, correlating EFNA genes in the tumor immune microenvironment (TIME), and the prognosis of patients with gastric cancer remains to be determined ...
Rongrong Xie, Mengping Yuan, Yiyan Jiang
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Construction of an interferon regulatory factors-related risk model for predicting prognosis, immune microenvironment and immunotherapy in clear cell renal cell carcinoma

Frontiers in Oncology, 2023
BackgroundInterferon regulatory factors (IRFs) played complex and essential roles in progression, prognosis, and immune microenvironment in clear cell renal cell carcinoma (ccRCC).
Hao Pan, Wei Lu, Mengyuan Zhang, Chengxiao Liu   +3 more
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