Results 11 to 20 of about 4,681,502 (208)

Polo like kinase 2 tumour suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer [PDF]

, 2012
The polo-like kinase PLK2 has recently been identified as a potential theranostic marker in the management of chemotherapy sensitive cancers. The methylation status of the PLK2 CpG island varies with sensitivity to paclitaxel and platinum in ovarian ...
Mcneish, I., Blagden, S., Hatzimichael, E., Syed, N., Coley, H.M., Crook, T., Thompson, A.   +6 more
core   +8 more sources

Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae [PDF]

, 2013
Trichuriasis represents a major public health problem in the developing world and is regarded as a neglected disease. Albendazole and mebendazole, the two drugs of choice against trichuriasis display only moderate cure rates, hence alternative drugs are ...
Jennifer Keiser, Keiser, Jennifer, Tritten, Lucienne, Lucienne Tritten, Wimmersberger, David, David Wimmersberger   +5 more
core   +1 more source

Immune-Related lncRNA Pairs as Prognostic Signature and Immune-Landscape Predictor in Lung Adenocarcinoma

Frontiers in Oncology, 2022
BackgroundSuppressive tumor microenvironment is closely related to the progression and poor prognosis of lung adenocarcinoma (LUAD). Novel individual and universal immune-related biomarkers to predict the prognosis and immune landscape of LUAD patients ...
Zhengrong Yin, Mei Zhou, Tingting Liao, Juanjuan Xu, Jinshuo Fan, Jingjing Deng, Yang Jin   +6 more
doaj   +1 more source

Integrated bioinformatical analysis, machine learning and in vitro experiment-identified m6A subtype, and predictive drug target signatures for diagnosing renal fibrosis

Frontiers in Pharmacology, 2022
Renal biopsy is the gold standard for defining renal fibrosis which causes calcium deposits in the kidneys. Persistent calcium deposition leads to kidney inflammation, cell necrosis, and is related to serious kidney diseases.
Chunxiang Feng, Zhixian Wang, Zhixian Wang, Chang Liu, Shiliang Liu, Yuxi Wang, Yuanyuan Zeng, Qianqian Wang, Tianming Peng, Xiaoyong Pu, Jiumin Liu   +10 more
doaj   +1 more source

The Role of Thiol-Cysteine Sensitivity in Modulating the Bioavailability and Efficacy of Drug Candidates [PDF]

, 2023
Thiols are essential biomolecules involved in many biological processes, including redox regulation and signal transduction. Thiols are ubiquitous in biological systems and can be reversibly modified by electrophilic compounds through a mechanism known ...
Kendis, Parks, Syon, Schlecht, Haley , Fleming   +2 more
core   +1 more source

A Metabolism-Related Gene Landscape Predicts Prostate Cancer Recurrence and Treatment Response

Frontiers in Immunology, 2022
BackgroundProstate cancer (PCa) is the most common malignant tumor in men. Although clinical treatments of PCa have made great progress in recent decades, once tolerance to treatments occurs, the disease progresses rapidly after recurrence.
Lijie Zhou, Lijie Zhou, Ruixin Fan, Ruixin Fan, Yongbo Luo, Yongbo Luo, Cai Zhang, Donghui Jia, Rongli Wang, Youmiao Zeng, Youmiao Zeng, Mengda Ren, Mengda Ren, Kaixuan Du, Kaixuan Du, Wenbang Pan, Wenbang Pan, Jinjian Yang, Jinjian Yang, Fengyan Tian, Chaohui Gu, Chaohui Gu   +21 more
doaj   +1 more source

Establishment and external verification of an oxidative stress-related gene signature to predict clinical outcomes and therapeutic responses of colorectal cancer

Frontiers in Pharmacology, 2023
Objective: Accumulated evidence highlights the biological significance of oxidative stress in tumorigenicity and progression of colorectal cancer (CRC).
Sha Cao, Cheng Chen, Dezhi Gu, Zhengdong Wang, Guanghui Xu   +4 more
doaj   +1 more source

Identification and validation of a novel cuproptosis-related genes signature associated with prognosis, clinical implications and immunotherapy of hepatocellular carcinoma

Frontiers in Pharmacology, 2023
Background: Cuproptosis is a novel type of regulated cell death and is reported to promote tumor occurrence and progression. However, whether a cuproptosis-related signature has an impact on hepatocellular carcinoma (HCC) is still unclear.Materials and ...
Fengjiao He, Fengjiao He, Fengjiao He, Puhua Zeng, Sijing Ma, Ximing Yang, Huan Liu, Huan Liu, Qiong Liu, Qiong Liu, Yangying Zhou, Yangying Zhou, Hong Zhu, Hong Zhu   +13 more
doaj   +1 more source

A novel prognostic gene set for colon adenocarcinoma relative to the tumor microenvironment, chemotherapy, and immune therapy

Frontiers in Genetics, 2023
Background: Colon adenocarcinoma (COAD) is a common aggressive malignant tumor. Heterogeneity in tumorigenesis and therapy response leads to an unsatisfactory overall survival of colon adenocarcinoma patients.
Hui Zhou, Yongxiang Wang, Zijian Zhang, Li Xiong, Zhongtao Liu, Yu Wen   +5 more
doaj   +1 more source

Subtypes analysis and prognostic model construction based on lysosome-related genes in colon adenocarcinoma

Frontiers in Genetics, 2023
Background: Lysosomes are essential for the development and recurrence of cancer. The relationship between a single lysosome-related gene and cancer has previously been studied, but the relationship between the lysosome-related genes (LRGs) and colon ...
Yang Chen, Yang Chen, Yunfei Lu, Yunfei Lu, Changzhi Huang, Changzhi Huang, Jingyu Wu, Jingyu Wu, Yu Shao, Yu Shao, Zhenling Wang, Zhenling Wang, Hongqiang Zhang, Hongqiang Zhang, Zan Fu, Zan Fu   +15 more
doaj   +1 more source