Results 21 to 30 of about 1,143,151 (266)

Preclinical Application of Conditional Reprogramming Culture System for Laryngeal and Hypopharyngeal Carcinoma

Frontiers in Cell and Developmental Biology, 2021
Management of laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) remains highly challenging due to highly variable therapeutic responses.
Yanbo Dong, Jian Wang, Wei Ji, Mengzhu Zheng, Peng Wang, Liangfa Liu, Shanhu Li   +6 more
doaj   +1 more source

Drug sensitivity of Proteus species [PDF]

Journal of Clinical Pathology, 1968
The results of sensitivity test for four Proteus species were compared. P. mirabilis was, in general, more drug sensitive than the other species and P. rettgeri was the least sensitive. The conclusion was drawn that species identification of Proteus is essential in routine bacteriological diagnosis.
C T, Huang, G, Chou
openaire   +2 more sources

A Novel hepatocellular carcinoma specific hypoxic related signature for predicting prognosis and therapeutic responses

Frontiers in Immunology, 2022
Hypoxia is an important feature of the tumor microenvironment(TME) and is closely associated with cancer metastasis, immune evasion, and drug resistance.
Guangzhen Cai, Jinghan Zhu, Deng Ning, Ganxun Li, Yuxin Zhang, Yixiao Xiong, Junnan Liang, Chengpeng Yu, Xiaoping Chen, Huifang Liang, Zeyang Ding   +10 more
doaj   +1 more source

RP11-616M22.7 recapitulates imatinib resistance in gastrointestinal stromal tumor

Molecular Therapy: Nucleic Acids, 2021
Emerging evidence has shown that long non-coding RNAs (lncRNAs) play crucial roles in human cancers. However, systematic characterization of lncRNAs and their roles in gastrointestinal stromal tumor (GIST) therapy have been lacking.
Yebo Shao, Shixian Lian, Jiajia Zheng, Hanxing Tong, Jiongyuan Wang, Jing Xu, Wenshuai Liu, Guoxiang Hu, Yong Zhang, Junyi He   +9 more
doaj   +1 more source

Context Sensitive Modeling of Cancer Drug Sensitivity

PLOS ONE, 2015
Recent screening of drug sensitivity in large panels of cancer cell lines provides a valuable resource towards developing algorithms that predict drug response. Since more samples provide increased statistical power, most approaches to prediction of drug sensitivity pool multiple cancer types together without distinction.
Chen, Bo-Juen, Pe'er, Dana, Litvin, Oren, Ungar, Lyle   +3 more
openaire   +5 more sources

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Synergistic effects of 5-fluorouracil in combination with salinomycin promoted ferroptosis via inhibiting SLC7A11/GPX4 in colorectal cancer

Frontiers in Oncology
Purpose5-Fluorouracil (5-FU) resistance is considered to be a possible reason for the failure of conventional drug treatment of colorectal cancer (CRC).
Can Wang, Junyang Wang, Fei Xing, Ning Liu, Xudong Wang   +4 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma

Frontiers in Pharmacology
ObjectiveOsteosarcoma is the most common primary bone cancer with a high propensity for local invasion and metastasis. An increasing number of research studies show that telomeres play an important role in the occurrence and development of cancer.
Shihao Li, Lina Zhang, Haiyang Zhang
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source