Results 111 to 120 of about 327,213 (361)

The rise of injecting drug use in East Africa: a case study from Kenya [PDF]

, 2005
Studies on injecting drug use in East Africa are reviewed. The existingstudies document the spread of heroin injection in Kenya and Tanzania, both countries where HIV rates are high. No data from Uganda on injecting drug use was found by the authors.
Gillian Hundt, Beckerleg Susan, Telfer Maggie, Hundt Gillian, Beckerleg, Susan, Hundt, Gillian Lewando, Maggie Telfer, Susan Beckerleg, Lewando Hundt, Gillian, Telfer , Maggie, Telfer, Maggie   +10 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

THE CORRELATION BETWEEN POOR ORAL HYGIENE AND ORAL HEALTH-RELATED QUALITY OF LIFE AMONG DRUG USERS

Jurnal Berkala Epidemiologi
Background: The quality of life among drug users has become an increasingly important public health issue. One of the factors suspected to contribute to this is poor oral hygiene, which may result from reduced saliva production due to long-term use of ...
Riky Hamdani, Alexander Sitepu, Indraswari Wahyu Pertiwi   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Beyond Addiction: Burden of Polypharmacy and Risk in Frail Patients with Substance Use Disorder

Pharmacy
Substance use disorder (SUD) is a chronic and clinically complex condition, frequently complicated by significant organic and psychiatric comorbidities. Most patients are polymedicated and require opioid substitution programs (OSPs).
L. Goretti Santiago Gutiérrez, Daida Alberto Armas, Verónica Hernández García, Juan Ramón Santana Ayala, Roberto García Sánchez, Soraya Paz Montelongo, Ángel J. Gutiérrez, Arturo Hardisson de la Torre, Carmen Rubio Armendáriz   +8 more
doaj   +1 more source

State Drug Control and Illicit Drug Participation [PDF]

The purpose of this paper is to estimate the effect of state criminal justice expenditures and state public health expenditures on deterring illicit drug use. The empirical model is based on a demand and supply model of drug markets.
Frank Chaloupka, Henry Saffer
core  

Visuospatial working memory impairment in current and previous ecstasy/polydrug users [PDF]

, 2011
Objective: Previous research suggests that ecstasy users are impaired in processing visuospatial information. However, for the most part, the deficits observed appear to involve the recall and recognition of complex visual and geometric patterns.
Montgomery, C, Fisk, John E., Catharine Montgomery, Hadjiefthyvoulou, F, John E. Fisk, Montgomery, Catharine, Fisk, JE, Florentia Hadjiefthyvoulou, Hadjiefthyvoulou, Florentia   +8 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Plea for Harm Reduction Policing Involving People Who Use Drugs [PDF]

International Journal of Health Policy and Management, 2018
Ehsan Jozaghi, Lorna Bird
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source