Results 1 to 10 of about 28,751 (255)

A deep learning framework for the detection and quantification of drusen and reticular pseudodrusen on optical coherence tomography [PDF]

Translational Vision Science & Technology, 2022
Purpose - To develop and validate a deep learning (DL) framework for the detection and quantification of drusen and reticular pseudodrusen (RPD) on optical coherence tomography scans. Design - Development and validation of deep learning models for classification and feature segmentation.
R. Schwartz, Hagar Khalid, S. Liakopoulos, Y. Ouyang, Coen de Vente, C. González-Gonzalo, Aaron Y. Lee, R. Guymer, E. Chew, C. Egan, Zhichao Wu, Himeesh Kumar, Joseph Farrington, C. S'anchez, A. Tufail   +14 more
arxiv   +3 more sources

Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors

Journal of Extracellular Vesicles, 2021
Age‐related macular degeneration (AMD) is a leading cause of blindness worldwide. Drusen are key contributors to the etiology of AMD and the ability to modulate drusen biogenesis could lead to therapeutic strategies to slow or halt AMD progression.
Miguel Flores‐Bellver, Jason Mighty, Silvia Aparicio‐Domingo, Kang V. Li, Cui Shi, Jing Zhou, Hannah Cobb, Patrick McGrath, German Michelis, Patricia Lenhart, Ganna Bilousova, Søren Heissel, Michael J. Rudy, Christina Coughlan, Andrew E. Goodspeed, S. Patricia Becerra, Stephen Redenti, M. Valeria Canto‐Soler   +17 more
doaj   +2 more sources

Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report

Scientific Reports, 2022
Drusen are hallmarks of early and intermediate age-related macular degeneration (AMD) but their quantification remains a challenge. We compared automated drusen volume measurements between different OCT devices.
Davide Garzone, Jan Henrik Terheyden, Olivier Morelle, Maximilian W. M. Wintergerst, Marlene Saßmannshausen, Steffen Schmitz-Valckenberg, Maximilian Pfau, Sarah Thiele, Stephen Poor, Sergio Leal, Frank G. Holz, Robert P. Finger, MACUSTAR Consortium   +12 more
doaj   +2 more sources

Multiclass segmentation as multitask learning for drusen segmentation in retinal optical coherence tomography [PDF]

arXiv, 2019
Automated drusen segmentation in retinal optical coherence tomography (OCT) scans is relevant for understanding age-related macular degeneration (AMD) risk and progression. This task is usually performed by segmenting the top/bottom anatomical interfaces that define drusen, the outer boundary of the retinal pigment epithelium (OBRPE) and the Bruch's ...
Rhona Asgari, J. Orlando, S. Waldstein, F. Schlanitz, M. Baratsits, U. Schmidt-Erfurth, H. Bogunović   +6 more
arxiv   +3 more sources

Association of soft drusen with risk of all-cause and specific-cause mortality in the National Health and Nutrition Examination Survey, 2005 to 2008 [PDF]

Scientific Reports
The aim of this study is to investigate the correlation between soft drusen and the likelihood of mortality from all causes and specific ailments within a representative United States population.
Huihui Wu, Xiaofang Wang, Yajun Liu, Ye Zhang, Ruiwen Cheng, Mengru Su, Xinghong Sun, Feng Jiang   +7 more
doaj   +2 more sources

U-Net with spatial pyramid pooling for drusen segmentation in optical coherence tomography [PDF]

arXiv, 2019
The presence of drusen is the main hallmark of early/intermediate age-related macular degeneration (AMD). Therefore, automated drusen segmentation is an important step in image-guided management of AMD. There are two common approaches to drusen segmentation. In the first, the drusen are segmented directly as a binary classification task.
Rhona Asgari, S. Waldstein, F. Schlanitz, M. Baratsits, U. Schmidt-Erfurth, H. Bogunović   +5 more
arxiv   +2 more sources

Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients.

PLoS ONE, 2021
Drusen are known to be the important hallmark to predict the development of age-related macular degeneration (AMD). The prevalence of drusen is lower in Asians compared with Caucasians so that the role of signs constituting early AMD is not well ...
Shoji Notomi, Satomi Shiose, Keijiro Ishikawa, Yosuke Fukuda, Kumiko Kano, Kenichiro Mori, Iori Wada, Yoshihiro Kaizu, Hidetaka Matsumoto, Masato Akiyama, Koh-Hei Sonoda   +10 more
doaj   +2 more sources

Developing an image-based grading scale for peripheral drusen to investigate associations of peripheral drusen type with age-related macular degeneration [PDF]

Scientific Reports
Age-related macular degeneration (AMD) is a leading cause of blindness. It is associated with peripheral drusen which has not been categorized. We investigated peripheral drusen to validate an image grading system and to understand possible associations ...
Paripoorna Sharma, Fritz Gerald P. Kalaw, Andrew Lin, Evan H. Walker, Shyamanga Borooah   +4 more
doaj   +2 more sources

Automatic Classification of Bright Retinal Lesions via Deep Network Features [PDF]

arXiv, 2017
The diabetic retinopathy is timely diagonalized through color eye fundus images by experienced ophthalmologists, in order to recognize potential retinal features and identify early-blindness cases. In this paper, it is proposed to extract deep features from the last fully-connected layer of, four different, pre-trained convolutional neural networks ...
Elawady, Mohamed, Sadek, Ibrahim, Shabayek, Abd El Rahman   +2 more
arxiv   +2 more sources

Automated segmentation and quantification of calcified drusen in 3D swept source OCT imaging.

Biomedical Optics Express, 2023
Qualitative and quantitative assessments of calcified drusen are clinically important for determining the risk of disease progression in age-related macular degeneration (AMD).
Jie Lu, Yuxuan Cheng, Jianqing Li, Ziyu Liu, Mengxi Shen, Qinqin Zhang, Jeremy Liu, Gissel Herrera, Farhan E. Hiya, Rosalyn Morin, Joan Joseph, Giovanni Gregori, P. Rosenfeld, Ruikang K Wang   +13 more
semanticscholar   +1 more source