Results 1 to 10 of about 22,577 (182)

Drusen-specific dark adaptation profiles in intermediate age-related macular degeneration [PDF]

International Journal of Retina and Vitreous
Aims To investigate the influence of macular drusen phenotypes on dark adaptation (DA) in intermediate age-related macular degeneration (iAMD). Methods This cross-sectional, multicentric study enrolled 57 eyes of 43 iAMD patients.
Paolo Forte, Lorenzo Ferro Desideri, Marco Nassisi, Federica Milanesi, Alessandro Feo, Irene Bagnasco, Sharlot M. Iglesia, Giovanni Forte, Davide Scandella, Fabiola Roccatagliata, Vincenzo Fontana, Chiara Maria Eandi, Michele Iester, Jasleen K. Jolly, Martin S. Zinkernagel, Francesco Viola, Massimo Nicolò   +16 more
doaj   +2 more sources

Choriocapillaris Flow and Retinal Vascular Fractal Dimension in Dry Age-Related Macular Degeneration [PDF]

Diagnostics
Background/Objective: To evaluate the association between optical coherence tomography angiography (OCTA)-derived choriocapillaris flow (CCflow), retinal vascular fractal dimension (FD), and drusen burden in eyes with dry age-related macular degeneration
Mine Ozturk, Abdullah Ağın
doaj   +2 more sources

Radiomic Characterization and Automated Classification of Drusen Substructure Phenotype Associated with High-Risk Dry Age-Related Macular Degeneration [PDF]

Diagnostics
Background/Objectives: Optical coherence tomography (OCT)-reflective drusen substructures (ODSs) are associated with the conversion of intermediate AMD to geographic atrophy (GA). However, ODSs must be manually identified, a laborious process introducing
Scott W. Perkins, Neal Shah, Jon Whitney, Karen Matar, Hannah J. Yu, Charles C. Wykoff, Justis P. Ehlers   +6 more
doaj   +2 more sources

Age-related macular degeneration, subretinal drusenoid deposits, and cuticular and calcified drusen in black and hispanic subjects [PDF]

International Journal of Retina and Vitreous
Background Subretinal drusenoid deposits (SDDs), cuticular drusen, and calcified drusen have been linked to rapid progression of age-related macular degeneration (AMD). SDDs have also been linked to high-risk vascular diseases (HRVDs).
John M. Tan, Yang Fei, Liang Wang, Oscar Otero-Marquez, Tasin R. Bhuiyan, J. Fernando Arevalo, Gareth M.C. Lema, Roland Theodore Smith   +7 more
doaj   +2 more sources

Low-Reflectivity Drusen With Overlying RPE Damage Revealed by Spectral-Domain OCT: Hint for the Development of Age-Related Macular Degeneration

Frontiers in Medicine, 2021
Purpose: To observe the relationship between the characteristic changes in the drusen morphology revealed by the spectral-domain optical coherence tomography (SD-OCT) and the progression of age-related macular degeneration (AMD).Methods: A total of 380 ...
Shasha Yang, Zongyin Gao, Haijiang Qiu, Chengguo Zuo, Lan Mi, Hui Xiao, Xing Liu   +6 more
doaj   +1 more source

The HIT Study—The Hydroxychloroquine Effect in the Treatment of Patients with Age-Related Macular Degeneration: A Randomized Controlled Trial

Medicina, 2023
Background and Objectives: Decreased age-related macular degeneration (AMD) has been reported in individuals with rheumatoid arthritis treated with hydroxychloroquine (HCQ, plaquenil).
Tal Yahalomi, Yoav Pikkel, Roee Arnon, Dafi Porat, Joseph Pikkel   +4 more
doaj   +1 more source

Drusen characteristics of type 2 macular neovascularization in age-related macular degeneration

BMC Ophthalmology, 2020
Background Type 2 macular neovascularization (MNV) is supposed to be a rare condition in age-related macular degeneration (AMD). The main purpose of this study was to assess accompanying factors of type 2 MNV in AMD.
Daniel Ahmed, Martin Stattin, Anna-Maria Haas, Alexandra Graf, Katharina Krepler, Siamak Ansari-Shahrezaei   +5 more
doaj   +1 more source

Small hard drusen and associated factors in early seniority.

PLoS ONE, 2022
PurposeThe purpose of this study was to examine the ocular and systemic risk profile of the fundus phenotype ≥ 20 small hard (macular) drusen (< 63 μm in diameter).MethodsThis single-center, cross-sectional study of 176 same-sex twin pairs aged 30 to 80 (
Mohamed Belmouhand, Simon P Rothenbuehler, Sami Dabbah, Jakob Bjerager, Birgit Sander, Jacob B Hjelmborg, Christine Dalgård, Rasmus Jensen, Michael Larsen   +8 more
doaj   +1 more source

Evaluation of the microperimetry in eyes with cuticular drusen

Scientific Reports, 2022
Retinal sensitivity may vary by subtypes of cuticular drusen. This retrospective study included 52 eyes of 32 patients with cuticular drusen. All the patients underwent assessment of best-corrected visual acuity (BCVA), spectral-domain optical coherence ...
Seung Wan Nam, Jung Hwa Lee, Zeeyoon Byun, Don-Il Ham, Mingui Kong   +4 more
doaj   +1 more source

Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors

Journal of Extracellular Vesicles, 2021
Age‐related macular degeneration (AMD) is a leading cause of blindness worldwide. Drusen are key contributors to the etiology of AMD and the ability to modulate drusen biogenesis could lead to therapeutic strategies to slow or halt AMD progression.
Miguel Flores‐Bellver, Jason Mighty, Silvia Aparicio‐Domingo, Kang V. Li, Cui Shi, Jing Zhou, Hannah Cobb, Patrick McGrath, German Michelis, Patricia Lenhart, Ganna Bilousova, Søren Heissel, Michael J. Rudy, Christina Coughlan, Andrew E. Goodspeed, S. Patricia Becerra, Stephen Redenti, M. Valeria Canto‐Soler   +17 more
doaj   +1 more source