Results 11 to 20 of about 32,629 (301)

Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors

Journal of Extracellular Vesicles, 2021
Age‐related macular degeneration (AMD) is a leading cause of blindness worldwide. Drusen are key contributors to the etiology of AMD and the ability to modulate drusen biogenesis could lead to therapeutic strategies to slow or halt AMD progression.
Miguel Flores‐Bellver, Jason Mighty, Silvia Aparicio‐Domingo, Kang V. Li, Cui Shi, Jing Zhou, Hannah Cobb, Patrick McGrath, German Michelis, Patricia Lenhart, Ganna Bilousova, Søren Heissel, Michael J. Rudy, Christina Coughlan, Andrew E. Goodspeed, S. Patricia Becerra, Stephen Redenti, M. Valeria Canto‐Soler   +17 more
doaj   +2 more sources

Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report

Scientific Reports, 2022
Drusen are hallmarks of early and intermediate age-related macular degeneration (AMD) but their quantification remains a challenge. We compared automated drusen volume measurements between different OCT devices.
Davide Garzone, Jan Henrik Terheyden, Olivier Morelle, Maximilian W. M. Wintergerst, Marlene Saßmannshausen, Steffen Schmitz-Valckenberg, Maximilian Pfau, Sarah Thiele, Stephen Poor, Sergio Leal, Frank G. Holz, Robert P. Finger, MACUSTAR Consortium   +12 more
doaj   +2 more sources

Association of Drusen Deposition with Choroidal Intercapillary Pillars in the Aging Human Eye [PDF]

, 2004
PURPOSE. To determine the pattern of drusen accumulation with age and to investigate the initial sites of deposition and their relationship to choroidal capillaries in human donor eyes from the eye bank of Moorfields Eye Hospital.METHODS.
Imre Lengyel, Adnan Tufail, Heba Al Hosaini, Philip J. Luthert, Alan C. Bird, Glen Jeffery   +5 more
openalex   +3 more sources

Age-related macular degeneration, subretinal drusenoid deposits, and cuticular and calcified drusen in black and hispanic subjects [PDF]

International Journal of Retina and Vitreous
Background Subretinal drusenoid deposits (SDDs), cuticular drusen, and calcified drusen have been linked to rapid progression of age-related macular degeneration (AMD). SDDs have also been linked to high-risk vascular diseases (HRVDs).
John M. Tan, Yang Fei, Liang Wang, Oscar Otero-Marquez, Tasin R. Bhuiyan, J. Fernando Arevalo, Gareth M.C. Lema, Roland Theodore Smith   +7 more
doaj   +2 more sources

A Method of Drusen Measurement Based on the Geometry of Fundus Reflectance [PDF]

BioMedical Engineering OnLine, 2003
Background The hallmarks of age-related macular degeneration, the leading cause of blindness in the developed world, are the subretinal deposits known as drusen.
Barbazetto Irene, Sparrow Janet R, Nagasaki Takayuki, Smith R Theodore, Klaver Caroline CW, Chan Jackie K   +5 more
doaj   +5 more sources

A Deep Learning Framework for the Detection and Quantification of Reticular Pseudodrusen and Drusen on Optical Coherence Tomography [PDF]

Translational Vision Science & Technology, 2022
Purpose The purpose of this study was to develop and validate a deep learning (DL) framework for the detection and quantification of reticular pseudodrusen (RPD) and drusen on optical coherence tomography (OCT) scans. Methods A DL framework was developed
R. Schwartz, Hagar Khalid, S. Liakopoulos, Y. Ouyang, Coen de Vente, C. González-Gonzalo, Aaron Y. Lee, R. Guymer, E. Chew, C. Egan, Zhichao Wu, Himeesh Kumar, Joseph Farrington, C. S'anchez, A. Tufail   +14 more
semanticscholar   +1 more source

Automated segmentation and quantification of calcified drusen in 3D swept source OCT imaging.

Biomedical Optics Express, 2023
Qualitative and quantitative assessments of calcified drusen are clinically important for determining the risk of disease progression in age-related macular degeneration (AMD).
Jie Lu, Yuxuan Cheng, Jianqing Li, Ziyu Liu, Mengxi Shen, Qinqin Zhang, Jeremy Liu, Gissel Herrera, Farhan E. Hiya, Rosalyn Morin, Joan Joseph, Giovanni Gregori, P. Rosenfeld, Ruikang K Wang   +13 more
semanticscholar   +1 more source

Relationship Between Drusen Height and OCT Biomarkers of Atrophy in Non-Neovascular AMD

Investigative Ophthalmology and Visual Science, 2022
Purpose To determine if increasing drusen height correlates with predictive optical coherence tomography (OCT) biomarkers of atrophy. Methods Retrospective cross-sectional study that enrolled patients with drusen associated with intermediate AMD. Macular
A. Au, Ahmad Santina, Neda Abraham, Miri Fogel Levin, G. Corradetti, S. Sadda, D. Sarraf   +6 more
semanticscholar   +1 more source

Optic Nerve Drusen Evaluation: A Comparison between Ultrasound and OCT

Journal of Clinical Medicine, 2022
This observational study compared optic coherence tomography (OCT) and B-scan in the detection of optic disc drusen. In total, 86 eyes of 50 patients with optic disc drusen (ODD) (36 bilateral) with a mean age of 34.68 ± 23.81 years, and 54 eyes of 27 ...
N. Rosa, Maddalena De Bernardo, Giulia Abbinante, G. Vecchio, Ferdinando Cione, L. Capasso   +5 more
semanticscholar   +1 more source

Low-Reflectivity Drusen With Overlying RPE Damage Revealed by Spectral-Domain OCT: Hint for the Development of Age-Related Macular Degeneration

Frontiers in Medicine, 2021
Purpose: To observe the relationship between the characteristic changes in the drusen morphology revealed by the spectral-domain optical coherence tomography (SD-OCT) and the progression of age-related macular degeneration (AMD).Methods: A total of 380 ...
Shasha Yang, Zongyin Gao, Haijiang Qiu, Chengguo Zuo, Lan Mi, Hui Xiao, Xing Liu   +6 more
doaj   +1 more source