Results 31 to 40 of about 25,200 (252)

Multispectral pattern recognition measures change in drusen area in age-related macular degeneration with high congruency to expert graders

Scientific Reports, 2022
Drusen are a hallmark lesion of age-related macular degeneration (AMD) and changes in their area and/or volume are strongly associated with disease progression. Assessment of longitudinal change in drusen size in clinical practice however is limited to a
Judy Nam, Angelica Ly, Michael Kalloniatis, Lisa Nivison-Smith   +3 more
doaj   +1 more source

Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells. [PDF]

, 2012
The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured
Birke, Kerstin, Burger, Johannes, Welge-Lussen, Ulrich, Yu, Alice L.   +3 more
core   +3 more sources

A Method of Drusen Measurement Based on the Geometry of Fundus Reflectance [PDF]

, 2003
BACKGROUND: The hallmarks of age-related macular degeneration, the leading cause of blindness in the developed world, are the subretinal deposits known as drusen.
A Abdelsalam, AC Bird, Caroline CW Klaver, CC Klaver, D Schweitzer, DM Snodderly, DS Shin, E Peli, FG Holz, Group The Choroidal Neovascularization Pr, HL Little, IC Frennesson, Irene Barbazetto, J Sigelman, J van de Kraats, Jackie K Chan, Janet R Sparrow, JC Russ, JJ Weiter, JM Bland, JN Kirkpatrick, K Rapantzikos, L Leistritz, M Sebag, MH Goldbaum, MS Figueroa, MS Figueroa, NM Bressler, NM Bressler, R Klein, R Theodore Smith, RA Bone, RL Radius, RT Smith, RT Smith, RW Knighton, SB Bressler, SB Bressler, Takayuki Nagasaki, TE Ogden, TE Ogden, WE Smiddy, WH Morgan   +42 more
core   +4 more sources

Ex Vivo Hyperspectral Autofluorescence Imaging and Localization of Fluorophores in Human Eyes with Age-Related Macular Degeneration

Vision, 2018
To characterize fluorophore signals from drusen and retinal pigment epithelium (RPE) and their changes in age related macular degeneration (AMD), the authors describe advances in ex vivo hyperspectral autofluorescence (AF) imaging of human eye tissue ...
Taariq Mohammed, Yuehong Tong, Julia Agee, Nayanika Challa, Rainer Heintzmann, Martin Hammer, Christine A. Curcio, Thomas Ach, Zsolt Ablonczy, R. Theodore Smith   +9 more
doaj   +1 more source

Retinal drusen in glomerulonephritis with or without immune deposits suggest systemic complement activation in disease pathogenesis

Scientific Reports, 2022
Retinal drusen are characteristic of macular degeneration and complement activation, but also occur in C3, lupus and IgA nephropathy. This cross-sectional observational study compared drusen counts in different forms of glomerulonephritis.
P. Harraka, H. Mack, D. Colville, D. Barit, D. Langsford, T. Pianta, F. Ierino, Judy Savige   +7 more
doaj   +1 more source

Macular neovascularization in eyes with pachydrusen

Scientific Reports, 2021
The natural history and clinical significance of pachydrusen is unclear. This study aims to compare the longitudinal changes of eyes with pachydrusen and soft drusen and progression to exudative macular neovascularisation (MNV). Patients with a diagnosis
Kelvin Yi Chong Teo, Kai Xiong Cheong, Ricardo Ong, Haslina Hamzah, Yasuo Yanagi, Tien Yin Wong, Usha Chakravarthy, Chui Ming Gemmy Cheung   +7 more
doaj   +1 more source

Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report

Scientific Reports, 2022
Drusen are hallmarks of early and intermediate age-related macular degeneration (AMD) but their quantification remains a challenge. We compared automated drusen volume measurements between different OCT devices.
Davide Garzone, Jan Henrik Terheyden, Olivier Morelle, Maximilian W. M. Wintergerst, Marlene Saßmannshausen, Steffen Schmitz-Valckenberg, Maximilian Pfau, Sarah Thiele, Stephen Poor, Sergio Leal, Frank G. Holz, Robert P. Finger, MACUSTAR Consortium   +12 more
doaj   +1 more source

In Vivo Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques. [PDF]

, 2017
Nonhuman primates are the only mammals to possess a true macula similar to humans, and spontaneously develop drusenoid lesions which are hallmarks of age-related macular degeneration (AMD).
Cunefare, David, Farsiu, Sina, Garzel, Laura, Munevar, Christian, Roberts, Jeffrey, Thomasy, Sara, Tieu, Eric, Wong, Brittany, Yiu, Glenn   +8 more
core   +2 more sources

Correlation between retinal function and microstructural foveal changes in intermediate age related macular degeneration [PDF]

, 2017
Purpose: To assess foveal microstructural changes influencing retinal sensitivity (RS) and fixation stability using microperimeter MP-1 in intermediate age-related macular degeneration (AMD).
Carnevale, Carmela, Cutini, Alessandro, Fragiotta, Serena, Vingolo, Enzo Maria   +3 more
core   +2 more sources

Cataract and optic disk drusen in a patient with glycogenosis and di George syndrome: clinical and molecular report [PDF]

, 2017
Background We report the ophthalmic findings of a patient with type Ia glycogen storage disease (GSD Ia), DiGeorge syndrome (DGS), cataract and optic nerve head drusen (ONHD).
Allegrini, D., Autelitano, A., Damante, G., Maver, A., Montanari, C., Montesano, G., Paci, S., Pece, A., Penco, S., Peterlin, B., Rossetti, L. M.   +10 more
core   +2 more sources