Results 31 to 40 of about 22,596 (200)

In Vivo Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques. [PDF]

, 2017
Nonhuman primates are the only mammals to possess a true macula similar to humans, and spontaneously develop drusenoid lesions which are hallmarks of age-related macular degeneration (AMD).
Cunefare, David, Farsiu, Sina, Garzel, Laura, Munevar, Christian, Roberts, Jeffrey, Thomasy, Sara, Tieu, Eric, Wong, Brittany, Yiu, Glenn   +8 more
core   +2 more sources

Complement C3 variant and the risk of age-related macular degeneration [PDF]

, 2007
Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors.
Armbrecht, AM, Bird, AC, Clayton, DG, Deary, IJ, Dhillon, B, Genetic Factors AMD Study G, Hayward, C, Khan, JC, Matharu, BK, Moore, AT, Morgan, J, Redmond, E, Sepp, T, Shahid, H, Thurlby, DA, Wright, AF, Yates, JRW   +16 more
core   +1 more source

Ex Vivo Hyperspectral Autofluorescence Imaging and Localization of Fluorophores in Human Eyes with Age-Related Macular Degeneration

Vision, 2018
To characterize fluorophore signals from drusen and retinal pigment epithelium (RPE) and their changes in age related macular degeneration (AMD), the authors describe advances in ex vivo hyperspectral autofluorescence (AF) imaging of human eye tissue ...
Taariq Mohammed, Yuehong Tong, Julia Agee, Nayanika Challa, Rainer Heintzmann, Martin Hammer, Christine A. Curcio, Thomas Ach, Zsolt Ablonczy, R. Theodore Smith   +9 more
doaj   +1 more source

Retinal drusen in glomerulonephritis with or without immune deposits suggest systemic complement activation in disease pathogenesis

Scientific Reports, 2022
Retinal drusen are characteristic of macular degeneration and complement activation, but also occur in C3, lupus and IgA nephropathy. This cross-sectional observational study compared drusen counts in different forms of glomerulonephritis.
P. Harraka, H. Mack, D. Colville, D. Barit, D. Langsford, T. Pianta, F. Ierino, Judy Savige   +7 more
doaj   +1 more source

Correlation between retinal function and microstructural foveal changes in intermediate age related macular degeneration [PDF]

, 2017
Purpose: To assess foveal microstructural changes influencing retinal sensitivity (RS) and fixation stability using microperimeter MP-1 in intermediate age-related macular degeneration (AMD).
Carnevale, Carmela, Cutini, Alessandro, Fragiotta, Serena, Vingolo, Enzo Maria   +3 more
core   +2 more sources

Macular neovascularization in eyes with pachydrusen

Scientific Reports, 2021
The natural history and clinical significance of pachydrusen is unclear. This study aims to compare the longitudinal changes of eyes with pachydrusen and soft drusen and progression to exudative macular neovascularisation (MNV). Patients with a diagnosis
Kelvin Yi Chong Teo, Kai Xiong Cheong, Ricardo Ong, Haslina Hamzah, Yasuo Yanagi, Tien Yin Wong, Usha Chakravarthy, Chui Ming Gemmy Cheung   +7 more
doaj   +1 more source

Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye. [PDF]

, 2015
Accumulation of protein- and lipid-containing deposits external to the retinal pigment epithelium (RPE) is common in the aging eye, and has long been viewed as the hallmark of age-related macular degeneration (AMD).
Bird, AC, Boldt, K, Bundy, JG, Fearn, S, Flinn, JM, Jones, EA, Kortvely, E, Lanzirotti, A, Lengyel, I, McPhail, DS, Pauleikhoff, L, Ratu, SG, Reffatto, V, Thompson, RB, Ueffing, M   +14 more
core   +1 more source

Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report

Scientific Reports, 2022
Drusen are hallmarks of early and intermediate age-related macular degeneration (AMD) but their quantification remains a challenge. We compared automated drusen volume measurements between different OCT devices.
Davide Garzone, Jan Henrik Terheyden, Olivier Morelle, Maximilian W. M. Wintergerst, Marlene Saßmannshausen, Steffen Schmitz-Valckenberg, Maximilian Pfau, Sarah Thiele, Stephen Poor, Sergio Leal, Frank G. Holz, Robert P. Finger, MACUSTAR Consortium   +12 more
doaj   +1 more source

Exploration of cuticular drusen: comprehensive analysis from multi-modal imaging characteristics to clinical diagnosis and treatment

Yanke Xuebao
With the application of multimodal imaging techniques, a specific subtype of age-related macular degeneration (AMD), known as cuticular drusen, has been identified.
ZHANG Guanghan, ZHANG Xiongze, JI Yuying
doaj   +1 more source

Cataract and optic disk drusen in a patient with glycogenosis and di George syndrome: clinical and molecular report [PDF]

, 2017
Background We report the ophthalmic findings of a patient with type Ia glycogen storage disease (GSD Ia), DiGeorge syndrome (DGS), cataract and optic nerve head drusen (ONHD).
Allegrini, D., Autelitano, A., Damante, G., Maver, A., Montanari, C., Montesano, G., Paci, S., Pece, A., Penco, S., Peterlin, B., Rossetti, L. M.   +10 more
core   +2 more sources