Results 41 to 50 of about 32,629 (301)
Scientific Reports, 2022 Drusen are a hallmark lesion of age-related macular degeneration (AMD) and changes in their area and/or volume are strongly associated with disease progression. Assessment of longitudinal change in drusen size in clinical practice however is limited to a
Judy Nam +3 more
doaj +1 more source
Soft Drusen in Age-Related Macular Degeneration: Biology and Targeting Via the Oil Spill Strategies
Investigative Ophthalmology and Visual Science, 2018 AMD is a major cause of legal blindness in older adults approachable through multidisciplinary research involving human tissues and patients. AMD is a vascular-metabolic-inflammatory disease, in which two sets of extracellular deposits, soft drusen/basal
C. Curcio
semanticscholar +1 more source
Complement C3 variant and the risk of age-related macular degeneration [PDF]
, 2007 Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors.
Armbrecht, AM +16 more
core +1 more source
Scientific Reports, 2022 Retinal drusen are characteristic of macular degeneration and complement activation, but also occur in C3, lupus and IgA nephropathy. This cross-sectional observational study compared drusen counts in different forms of glomerulonephritis.
P. Harraka +7 more
doaj +1 more source
Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells. [PDF]
, 2012 The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured
Birke, Kerstin +3 more
core +3 more sources
Macular neovascularization in eyes with pachydrusen
Scientific Reports, 2021 The natural history and clinical significance of pachydrusen is unclear. This study aims to compare the longitudinal changes of eyes with pachydrusen and soft drusen and progression to exudative macular neovascularisation (MNV). Patients with a diagnosis
Kelvin Yi Chong Teo +7 more
doaj +1 more source
Vision, 2018 To characterize fluorophore signals from drusen and retinal pigment epithelium (RPE) and their changes in age related macular degeneration (AMD), the authors describe advances in ex vivo hyperspectral autofluorescence (AF) imaging of human eye tissue ...
Taariq Mohammed +9 more
doaj +1 more source
Acta ophthalmologica, 2020 Optic disc drusen (ODD) are calcified optic nerve head deposits. Objectives of this study were to examine the prevalence of ODD in eyes removed by enucleation and to describe related histopathological signatures of ODD and surrounding tissues.
M. Skougaard +3 more
semanticscholar +1 more source
Российский офтальмологический журнал, 2022 Purpose: to study the nature of changes in morphological parameters of the children’s optic disc and peripapillary retina in cases of congenital pathology.Material and methods.
T. V. Sudovskaya, L. V. Kogoleva
doaj +1 more source
In Vivo Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques. [PDF]
, 2017 Nonhuman primates are the only mammals to possess a true macula similar to humans, and spontaneously develop drusenoid lesions which are hallmarks of age-related macular degeneration (AMD).
Cunefare, David +8 more
core +2 more sources