Results 41 to 50 of about 31,224 (320)
Cataract and optic disk drusen in a patient with glycogenosis and di George syndrome: clinical and molecular report [PDF]
, 2017 Background We report the ophthalmic findings of a patient with type Ia glycogen storage disease (GSD Ia), DiGeorge syndrome (DGS), cataract and optic nerve head drusen (ONHD).
Allegrini, D. +10 more
core +2 more sources
Correlation between retinal function and microstructural foveal changes in intermediate age related macular degeneration [PDF]
, 2017 Purpose: To assess foveal microstructural changes influencing retinal sensitivity (RS) and fixation stability using microperimeter MP-1 in intermediate age-related macular degeneration (AMD).
Carnevale, Carmela +3 more
core +2 more sources
The Proteomics of Drusen [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 The formation of extracellular deposits known as drusen below the macular region of the retina correlates with increased risk of severe visual loss from age-related macular degeneration (AMD). Inflammation and complement dysregulation contribute to AMD progression; however, disease mechanisms remain incompletely defined.
openaire +3 more sources
Scientific Reports, 2022 Retinal drusen are characteristic of macular degeneration and complement activation, but also occur in C3, lupus and IgA nephropathy. This cross-sectional observational study compared drusen counts in different forms of glomerulonephritis.
P. Harraka +7 more
doaj +1 more source
Acta ophthalmologica, 2020 Optic disc drusen (ODD) are calcified optic nerve head deposits. Objectives of this study were to examine the prevalence of ODD in eyes removed by enucleation and to describe related histopathological signatures of ODD and surrounding tissues.
M. Skougaard +3 more
semanticscholar +1 more source
Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye. [PDF]
, 2015 Accumulation of protein- and lipid-containing deposits external to the retinal pigment epithelium (RPE) is common in the aging eye, and has long been viewed as the hallmark of age-related macular degeneration (AMD).
Bird, AC +14 more
core +1 more source
Soft Drusen in Age-Related Macular Degeneration: Biology and Targeting Via the Oil Spill Strategies
Investigative Ophthalmology and Visual Science, 2018 AMD is a major cause of legal blindness in older adults approachable through multidisciplinary research involving human tissues and patients. AMD is a vascular-metabolic-inflammatory disease, in which two sets of extracellular deposits, soft drusen/basal
C. Curcio
semanticscholar +1 more source
Macular neovascularization in eyes with pachydrusen
Scientific Reports, 2021 The natural history and clinical significance of pachydrusen is unclear. This study aims to compare the longitudinal changes of eyes with pachydrusen and soft drusen and progression to exudative macular neovascularisation (MNV). Patients with a diagnosis
Kelvin Yi Chong Teo +7 more
doaj +1 more source
Российский офтальмологический журнал, 2022 Purpose: to study the nature of changes in morphological parameters of the children’s optic disc and peripapillary retina in cases of congenital pathology.Material and methods.
T. V. Sudovskaya, L. V. Kogoleva
doaj +1 more source
Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules [PDF]
, 2019 The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called ...
Cerini, Alberto +5 more
core +1 more source