Results 41 to 50 of about 25,200 (252)

Exploration of cuticular drusen: comprehensive analysis from multi-modal imaging characteristics to clinical diagnosis and treatment

Yanke Xuebao
With the application of multimodal imaging techniques, a specific subtype of age-related macular degeneration (AMD), known as cuticular drusen, has been identified.
ZHANG Guanghan, ZHANG Xiongze, JI Yuying
doaj   +1 more source

Prevalence of age-related macular degeneration in Nakuru, Kenya: a cross-sectional population-based study. [PDF]

, 2013
BACKGROUND: Diseases of the posterior segment of the eye, including age-related macular degeneration (AMD), have recently been recognised as the leading or second leading cause of blindness in several African countries.
Bastawrous, Andrew, Foster, Allen, Kuper, Hannah, Leung, Irene, Mathenge, Wanjiku, Peto, Tunde   +5 more
core   +6 more sources

Morphometric parameters of the optic disc and peripapillary retina in children in cases of congenital pathology

Российский офтальмологический журнал, 2022
Purpose: to study the nature of changes in morphological parameters of the children’s optic disc and peripapillary retina in cases of congenital pathology.Material and methods.
T. V. Sudovskaya, L. V. Kogoleva
doaj   +1 more source

Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye. [PDF]

, 2015
Accumulation of protein- and lipid-containing deposits external to the retinal pigment epithelium (RPE) is common in the aging eye, and has long been viewed as the hallmark of age-related macular degeneration (AMD).
Bird, AC, Boldt, K, Bundy, JG, Fearn, S, Flinn, JM, Jones, EA, Kortvely, E, Lanzirotti, A, Lengyel, I, McPhail, DS, Pauleikhoff, L, Ratu, SG, Reffatto, V, Thompson, RB, Ueffing, M   +14 more
core   +1 more source

Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. [PDF]

, 2017
Age-related macular degeneration (AMD) ranks third among the leading causes of visual impairment with a blindness prevalence rate of 8.7%. Despite several treatment regimens, such as anti-angiogenic drugs, laser therapy, and vitamin supplementation ...
Chwa, Marilyn, Cohen, Pinchas, Kenney, M Cristina, Kuppermann, Baruch D, Lu, Stephanie, Nashine, Sonali, Nesburn, Anthony B   +6 more
core   +1 more source

Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model

Nature Communications, 2021
Age-related macular degeneration is characterized by lipid-rich drusen deposits underneath the retinal pigment epithelium (RPE). Here the authors report an in vitro iPSC-RPE model for AMD that recapitulates drusen and RPE atrophy, and identify two drugs ...
Ruchi Sharma, Aman George, Malika Nimmagadda, Davide Ortolan, Barbosa-Sabanero Karla, Zoya Qureshy, Devika Bose, Roba Dejene, Genqing Liang, Qin Wan, Justin Chang, Balendu Shekhar Jha, Omar Memon, Kiyoharu Joshua Miyagishima, Aaron Rising, Madhu Lal, Eric Hanson, Rebecca King, Mercedes Maria Campos, Marc Ferrer, Juan Amaral, David McGaughey, Kapil Bharti   +22 more
doaj   +1 more source

Developing an image-based grading scale for peripheral drusen to investigate associations of peripheral drusen type with age-related macular degeneration

Scientific Reports
Age-related macular degeneration (AMD) is a leading cause of blindness. It is associated with peripheral drusen which has not been categorized. We investigated peripheral drusen to validate an image grading system and to understand possible associations ...
Paripoorna Sharma, Fritz Gerald P. Kalaw, Andrew Lin, Evan H. Walker, Shyamanga Borooah   +4 more
doaj   +1 more source

Pseudotumor cerebri syndrome in childhood : incidence, clinical profile and risk factors in a national prospective population-based cohort study [PDF]

, 2017
Aim To investigate the epidemiology, clinical profile and risk factors of pseudotumor cerebri syndrome (PTCS) in children aged 1-16 years. Methods A national prospective population-based cohort study over 25 months.
Dean, Fiona, Kennedy, Colin R., Lim, Ming J., Matthews, Yim-Yee, Mclachlan, Karen, Rigby, Alan S., Solanki, Guirish A., White, Catharine P., Whitehouse, William P.   +8 more
core   +3 more sources

Secretory autophagy and epithelial‐to‐mesenchymal transition in cadaveric AMD samples: Novel pathways in disease progression

Acta Ophthalmologica, EarlyView.
Abstract Purpose To examine the presence of secretory autophagy and epithelial–mesenchymal transition (EMT) in the macular retinal pigment epithelium (RPE) of human cadaver eyes with different forms of age‐related macular degeneration (AMD). Methods Human cadaver macula samples representing dry and wet AMD, as well as age‐matched controls, were ...
Iswariyaraja Sridevi Gurubaran, Ali Koskela, Hanna Heloterä, Kai Kaarniranta   +3 more
wiley   +1 more source

Drusen Segmentation From Retinal Images via Supervised Feature Learning

IEEE Access, 2018
This paper presents a supervised feature learning method to learn discriminative and compact descriptors for drusen segmentation from retinal images.
Xiuxiu Ren, Yuanjie Zheng, Yanna Zhao, Chao Luo, Hong Wang, Jian Lian, Yunlong He   +6 more
doaj   +1 more source