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Virus Research, 2004
The dsRNA viruses represent a large, diverse group of pathogens (affecting a very wide range of host species), several of which are of medical, veterinary or agricultural importance. Many of the icosahedral dsRNA viruses show striking structural and functional similarities that reflect the similar problems that they face replicating their dsRNA genomes
Peter P C Mertens
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The dsRNA viruses represent a large, diverse group of pathogens (affecting a very wide range of host species), several of which are of medical, veterinary or agricultural importance. Many of the icosahedral dsRNA viruses show striking structural and functional similarities that reflect the similar problems that they face replicating their dsRNA genomes
Peter P C Mertens
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The competitive landscape of the dsRNA world
Molecular CellThe ability to sense and respond to infection is essential for life. Viral infection produces double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of dsRNA. This structure-based recognition of viral dsRNA allows dsRNA sensors to recognize infection by many viruses, but it comes at a cost-the dsRNA sensors cannot always
Kyle A Cottrell +2 more
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Specific interference by ingested dsRNA
Nature, 1998A genetic interference phenomenon in the nematode Caenorhabditis elegans has been described in which expression of an individual gene can be specifically reduced by microinjecting a corresponding fragment of double-stranded (ds) RNA1. One striking feature of this process is a spreading effect: interference in a broad region of the animal is observed ...
L, Timmons, A, Fire
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Murine immunosuppression with mycoviral dsRNA
Immunopharmacology, 1982The effect of three different size molecular weight species of mycoviral dsRNA on the immune response to sRBC was tested in C57Bl/6 mice. The various dsRNA species were extracted from electrophoresis polyacrylamide-agarose slab gels. Their molecular weights ranged from 1.0 x 10(6) daltons to 3.5 x 10(6) daltons.
C W, Hewitt, J P, Adler
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Activation of the dsRNA-Dependent Kinase
1994The double-stranded RNA (dsRNA)-dependent protein kinase, designated here as dsI, but also referred to as DAI, Pl kinase, p68 kinase and PI/eIF-2α protein kinase, is an interferon-induced serine/threonine protein kinase. It is uniquely distinguished from other protein kinases in that its activation to a functional enzyme, and in some cases prevention ...
R A, Petryshyn, J, Li, R, Judware
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2011
Several families of viruses have segmented genomes with 3-12 chromosomes. They are capable of packaging these segments in a precise manner so that each virus particle contains one each of the genomic segments. The Cystoviridae are a family of bacteriophages that contain three genomic segments of dsRNA.
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Several families of viruses have segmented genomes with 3-12 chromosomes. They are capable of packaging these segments in a precise manner so that each virus particle contains one each of the genomic segments. The Cystoviridae are a family of bacteriophages that contain three genomic segments of dsRNA.
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Mechanism of the Antiretroviral Effect of dsRNA
1994The development of AIDS seems to be linked to an impairment of processes which are induced or activated by double-stranded RNA (dsRNA), such as the biosynthesis of interferon (IFN), production of 2′,5′-oligoadenylate (2-5A), ribonuclease L (RNase L) activity and different cell-mediated immune functions. A restriction of available bioactive dsRNA (or of
W E, Müller +2 more
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Science, 2008
Toll-like receptors recognize molecules associated with pathogens and initiate inflammatory responses. For example, Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), an intermediate viral replication. The TLR3 ectodomain binds as a dimer to dsRNA, but the molecular basis for signaling remains unclear.
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Toll-like receptors recognize molecules associated with pathogens and initiate inflammatory responses. For example, Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), an intermediate viral replication. The TLR3 ectodomain binds as a dimer to dsRNA, but the molecular basis for signaling remains unclear.
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2019
This chapter describes the practical value for attempting to detect and describes the double-stranded (dsRNAs) lies in the ease with which they can be isolated and characterized. Most diagnostic laboratories recognize the value of less specific tests which can be used in addition to specific tests in the early testing stages, especially when the ...
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This chapter describes the practical value for attempting to detect and describes the double-stranded (dsRNAs) lies in the ease with which they can be isolated and characterized. Most diagnostic laboratories recognize the value of less specific tests which can be used in addition to specific tests in the early testing stages, especially when the ...
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Archives of Biochemistry and Biophysics, 2016
Double stranded RNA (dsRNA) participates in several biological processes, where RNA molecules acquire secondary structure inside the cell through base complementarity. The double stranded RNA binding domain (dsRBD) is one of the main protein folds that is able to recognize and bind to dsRNA regions. The N-terminal dsRBD of DCL1 in Arabidopsis thaliana (
Drusin, Salvador Iván +4 more
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Double stranded RNA (dsRNA) participates in several biological processes, where RNA molecules acquire secondary structure inside the cell through base complementarity. The double stranded RNA binding domain (dsRBD) is one of the main protein folds that is able to recognize and bind to dsRNA regions. The N-terminal dsRBD of DCL1 in Arabidopsis thaliana (
Drusin, Salvador Iván +4 more
openaire +3 more sources