Results 321 to 330 of about 114,219 (358)
Specific interference by ingested dsRNA
Nature, 1998 A genetic interference phenomenon in the nematode Caenorhabditis elegans has been described in which expression of an individual gene can be specifically reduced by microinjecting a corresponding fragment of double-stranded (ds) RNA1. One striking feature of this process is a spreading effect: interference in a broad region of the animal is observed ...
Andrew Fire, Lisa Timmons
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Journal of Agricultural and Food Chemistry, 2022
Developing safe and effective double-stranded RNA (dsRNA) delivery systems remains a major challenge for gene silencing, especially in lepidopteran insects. This study evaluated the protamine sulfate (PS)/lipid/dsRNA nanoparticle (NP) delivery system for
Ramesh Kumar Dhandapani +2 more
semanticscholar +1 more source
Developing safe and effective double-stranded RNA (dsRNA) delivery systems remains a major challenge for gene silencing, especially in lepidopteran insects. This study evaluated the protamine sulfate (PS)/lipid/dsRNA nanoparticle (NP) delivery system for
Ramesh Kumar Dhandapani +2 more
semanticscholar +1 more source
ACS Applied Bio Materials, 2021
Chickpea pod borer, Helicoverpa armigera, displays resistance to chemical insecticides and transgenics. The potential nontransformative RNAi approach of specific gene silencing by mRNA breakdown through exogenous double-stranded (dsRNA) delivery to ...
Henry Kolge +4 more
semanticscholar +1 more source
Chickpea pod borer, Helicoverpa armigera, displays resistance to chemical insecticides and transgenics. The potential nontransformative RNAi approach of specific gene silencing by mRNA breakdown through exogenous double-stranded (dsRNA) delivery to ...
Henry Kolge +4 more
semanticscholar +1 more source
, 2016
DNA methyltransferase inhibitors (DNMTis) upregulate immune attraction, including the interferon response, in solid tumors. We now define viral defense signaling as one mechanism for this.
Katherine B. Chiappinelli +17 more
semanticscholar +1 more source
DNA methyltransferase inhibitors (DNMTis) upregulate immune attraction, including the interferon response, in solid tumors. We now define viral defense signaling as one mechanism for this.
Katherine B. Chiappinelli +17 more
semanticscholar +1 more source
A dsRNA detector in the immune toolkit [PDF]
Science, 2021 Innate Immunity Nod-like receptor (NLR) proteins recognize pathogen-associated molecular patterns within cells, which triggers the formation of signaling complexes called inflammasomes. These complexes then initiate pyroptosis, a highly inflammatory form of cell death.
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Murine immunosuppression with mycoviral dsRNA
Immunopharmacology, 1982The effect of three different size molecular weight species of mycoviral dsRNA on the immune response to sRBC was tested in C57Bl/6 mice. The various dsRNA species were extracted from electrophoresis polyacrylamide-agarose slab gels. Their molecular weights ranged from 1.0 x 10(6) daltons to 3.5 x 10(6) daltons.
J.P. Adler, Charles W. Hewitt
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Virus Research, 2004
The dsRNA viruses represent a large, diverse group of pathogens (affecting a very wide range of host species), several of which are of medical, veterinary or agricultural importance. Many of the icosahedral dsRNA viruses show striking structural and functional similarities that reflect the similar problems that they face replicating their dsRNA genomes
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The dsRNA viruses represent a large, diverse group of pathogens (affecting a very wide range of host species), several of which are of medical, veterinary or agricultural importance. Many of the icosahedral dsRNA viruses show striking structural and functional similarities that reflect the similar problems that they face replicating their dsRNA genomes
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Pest Management Science, 2019
BACKGROUND It is difficult to efficiently silence gene expression in some insects, probably because of the degradation of dsRNA by enzymes present in the gut and hemolymph post-oral feeding or body injecting of dsRNA.
Yang Zheng +6 more
semanticscholar +1 more source
BACKGROUND It is difficult to efficiently silence gene expression in some insects, probably because of the degradation of dsRNA by enzymes present in the gut and hemolymph post-oral feeding or body injecting of dsRNA.
Yang Zheng +6 more
semanticscholar +1 more source
Mechanism of the Antiretroviral Effect of dsRNA
1994The development of AIDS seems to be linked to an impairment of processes which are induced or activated by double-stranded RNA (dsRNA), such as the biosynthesis of interferon (IFN), production of 2′,5′-oligoadenylate (2-5A), ribonuclease L (RNase L) activity and different cell-mediated immune functions. A restriction of available bioactive dsRNA (or of
Heinz-Christoph Schröder +2 more
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