Results 21 to 30 of about 1,165,839 (240)

A Fish MDA5 Integrates Canonical RIG-I and MDA5 Ligand Recognition. [PDF]

Adv Sci (Weinh)
These results show that the large yellow croaker lacks RIG‐I, yet its MDA5 senses both 5′ppp‐dsRNA and long dsRNA. A flexible RNA‐capping loop in the MDA5 C‐terminal domain enables two ligand‐binding modes. This dual recognition signals through MAVS–STING–TBK1/IRF3 and induces type I interferons, revealing unexpected plasticity in vertebrate antiviral ...
Li W, Feng Y, Chen H, Liu J, Fernández Montero Á, Gao J, Ao J, Chen X.   +7 more
europepmc   +2 more sources

Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation. [PDF]

, 2021
Thus, the present study is focused on the chitosan-dsRNA interactions and the physicochemical properties of the dsRNA-loaded nanoparticles, including cytotoxicity and hemolysis assays. dsRNA molecules homologous to a partial genome of the phytopathogenic
INOUE-NAGATA, A. K., Barros-Alexandrino, Tais T., Nagata, Alice K. I., LIMA, A. M. F., PILON, L., Pilon, Lucimeire, Petrônio, Maicon S. [UNESP], Tiera, Marcio J. [UNESP], NAKASU, E. Y. T., PETRÔNIO, M. S., TIERA, M. J., BARROS-ALEXANDRINO, T. T., ASSIS, O. B. G. de, Lima, Aline M. F. [UNESP], Nakasu, Erich Y. T., Assis, Odilio B. G., Lima, Aline M. F., Petrônio, Maicon S., ASSIS, O. B. G., Tiera, Marcio J.   +19 more
core   +1 more source

Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs [PDF]

, 2003
Double-stranded RNA (dsRNA) is a by-product of viral RNA polymerase activity, and its recognition is one mechanism by which the innate immune system is activated.
Boyd, A., Boyd, A, Fazakerley, John K., Weber, F, Elliott, Richard M., Fazakerley, John K, Weber, Friedemann, Weber, F., Streitenfeld, Hein, J. K. Fazakerley, Elliott, Richard M, Boyd, Amanda, H. Streitenfeld, Elliott, R.M., Streitenfeld, H., A. Bridgen, Bridgen, A., Streitenfeld, H, Fazakerley, J K, Fazakerley, J.K., F. Weber, R. M. Elliott, Bridgen, A, Elliott, Richard Michael, Bridgen, Anne, A. Boyd   +25 more
core   +1 more source

RNA interference targets arbovirus replication in Culicoides cells [PDF]

, 2013
Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms.
Varela, Mariana, Esther Schnettler, Ratinier, Maxime, Shaw, Andrew, Palmarini, Massimo, Kohl, Alain, Mariana Varela, Mick Watson, Elliott, Richard M., Alain Kohl, Maxime Ratinier, McFarlane, Melanie, Shaw, Andrew E., Elliott, Richard, Richard M, Massimo Palmarini, Schnettler, Esther, E. Shaw, Watson, Mick, A Alain Kohla, Melanie Mcfarlane   +20 more
core   +1 more source

Double-stranded RNA elements associated with the MVX disease of Agaricus bisporus [PDF]

, 2003
Double-stranded RNA (dsRNA) has been isolated from Agaricus bisporus fruit bodies exhibiting a wide range of disease symptoms. The symptoms which occurred singularly or in combination included; bare cropping areas on commercial beds (primordia disruption)
Adie, Bruce A. T., Grogan, Helen M., Gaze, R. H., Challen, Michael P., Millis, P. R. (Peter R.)   +4 more
core   +1 more source

Subunit Folds and Maturation Pathway of a dsRNA Virus Capsid [PDF]

Structure, 2013
The cystovirus ϕ6 shares several distinct features with other double-stranded RNA (dsRNA) viruses, including the human pathogen, rotavirus: segmented genomes, nonequivalent packing of 120 subunits in its icosahedral capsid, and capsids as compartments for transcription and replication.
Nemecek, Daniel, Boura, Evzen, Wu, Weimin, Cheng, Naiqian, Plevka, Pavel, Qiao, Jian, Mindich, Leonard, Heymann, J Bernard, Hurley, James H, Steven, Alasdair C   +9 more
openaire   +4 more sources

Exchange of the C-terminal part of VP3 from very virulent infectious bursal disease virus results in an attenuated virus with a unique antigenic structure [PDF]

, 2002
Infectious bursal disease virus (IBDV) is the major viral pathogen in the poultry industry. Live attenuated serotype 1 vaccine strains are commonly used to protect susceptible chickens during their first 6 weeks of life. Wild-type serotype 1 IBDV strains
Peeters, B.P.H., Pol, J.M., Hoekman, A.J.W., Huurne, A.A.H.M., ter, Boot, H.J., Gielkens, A.L.J.   +5 more
core   +1 more source

Full Genome Characterisation of Bluetonge Virus Seroptype 6 from the Netherlands 2008 and Comparison to Other Field and Vaccine Strains [PDF]

, 2010
In mid September 2008, clinical signs of bluetongue (particularly coronitis) were observed in cows on three different farms in eastern Netherlands (Luttenberg, Heeten, and Barchem), two of which had been vaccinated with an inactivated BTV-8 vaccine ...
Hoffmann, B., Wright Isabel M., Eschbaumer, M., Anna Sanders, Kyriaki Nomikou, Carrie Batten, van Rijn, Piet A., Maan, S., René G P van Gennip, Gennip, H.G.P., van, Chris A L Oura, van Gennip René G. P., Batten Carrie, Maan, Sushila, van Rijn, P.A., Oura Chris A. L., Sanders, Anna, Mertens, P.P.C., Eschbaumer, Michael, Mertens, Peter P.C., van Rijn Piet A., Oura, Chris A. L., Potgieter, C., Sushila Maan, Peter P C Mertens, Eschbaumer Michael, Hoffmann, Bernd, Maan, N.S., Wright, I.M., Potgieter, Abraham C., Narender S Maan, Nomikou, K., Nomikou Kyriaki, van Gennip, René G. P., Abraham C Potgieter, Oura, C.A.L., Bernd Hoffmann, Wright, Isabel M., Sanders Anna, Potgieter Abraham C., Maan Sushila, Piet A van Rijn, Maan Narender S., Hoffmann Bernd, Batten, Carrie, Isabel M Wright, Rijn, P.A., van, Batten, C., Maan, Narender S., Mertens Peter P.C., Sanders, A.A., Michael Eschbaumer, Nomikou, Kyriaki, Potgieter, A.C., van Gennip, R.G.P., Sanders, A.   +55 more
core   +1 more source

Visualization of Double-Stranded RNA Colocalizing With Pattern Recognition Receptors in Arenavirus Infected Cells

Frontiers in Cellular and Infection Microbiology, 2018
An important step in the initiation of the innate immune response to virus infection is the recognition of non-self, viral RNA, including double-stranded RNA (dsRNA), by cytoplasmic pattern recognition receptors (PRRs).
Elizabeth J. Mateer, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source

Sensitivity and specificity of anti-double-stranded RNA immunofluorescence for universal detection of viral infection in respiratory specimens

Heliyon, 2021
Background: Emerging viruses could be detected before reaching pandemic level if universal viral detection screening was routinely used. Double-stranded RNA (dsRNA) is the only common antigen across most viral families.
Kornthara Kawang, Udsanee Naoudom, Ekasit Kowitdamrong, Stephen J. Kerr, Kiat Ruxrungtham, Voraphoj Nilaratanakul   +5 more
doaj   +1 more source