Results 41 to 50 of about 1,165,839 (240)

Identification of the Active Sites in the Methyltransferases of a Transcribing dsRNA Virus

Journal of Molecular Biology, 2014
Many double-stranded RNA (dsRNA) viruses are capable of transcribing and capping RNA within a stable icosahedral viral capsid. The turret of turreted dsRNA viruses belonging to the family Reoviridae is formed by five copies of the turret protein, which contains domains with both 7-N-methyltransferase and 2'-O-methyltransferase activities, and serves to
Zhu, Bin, Yang, Chongwen, Liu, Hongrong, Cheng, Lingpeng, Song, Feng, Zeng, Songjun, Huang, Xiaojun, Ji, Gang, Zhu, Ping   +8 more
openaire   +2 more sources

Structural basis for dsRNA recognition by NS1 protein of influenza A virus [PDF]

Cell Research, 2008
Influenza A viruses are important human pathogens causing periodic pandemic threats. Nonstructural protein 1 (NS1) protein of influenza A virus (NS1A) shields the virus against host defense. Here, we report the crystal structure of NS1A RNA-binding domain (RBD) bound to a double-stranded RNA (dsRNA) at 1.7A.
Cheng, A., Wong, S.M., Yuan, Y.A.
openaire   +2 more sources

Exogenous Application of RNAi-Inducing Double-Stranded RNA Inhibits Aphid-Mediated Transmission of a Plant Virus

Frontiers in Plant Science, 2019
Plant viruses are difficult to control, and they decrease both the quality and yield of crops, thus threatening global food security. A new approach that uses topical application of double-stranded RNA (dsRNA) to induce antiviral RNA-interference has ...
Elizabeth A. Worrall, Ana Bravo-Cazar, Alexander T. Nilon, Stephen J. Fletcher, Karl E. Robinson, John P. Carr, Neena Mitter   +6 more
doaj   +1 more source

Use of High-Throughput Sequencing and Two RNA Input Methods to Identify Viruses Infecting Tomato Crops

Microorganisms, 2021
We used high-throughput sequencing to identify viruses on tomato samples showing virus-like symptoms. Samples were collected from crops in the Iberian Peninsula.
Ayoub Maachi, Covadonga Torre, Raquel N. Sempere, Yolanda Hernando, Miguel A. Aranda, Livia Donaire   +5 more
doaj   +1 more source

Analysis of the dsRNAs of apple chlorotic leaf spot virus

Journal of General Virology, 1992
Double-stranded RNAs were isolated from plants infected with five different isolates of apple chlorotic leaf spot virus (ACLSV). Analysis by PAGE and by Northern blot hybridization showed that six major species of viral dsRNA of approximately 7.5, 6.4, 5.4, 2.2, 1.1 and 1.0 kbp can be detected in infected plants, irrespective of the ACLSV isolate used.
German-Retana, Sylvie, Candresse, Thierry, Le Gall, Olivier, Lanneau, Maryvonne, Dunez, Jean   +4 more
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The Effect of Oral Administration of dsRNA on Viral Replication and Mortality in Bombus terrestris

Viruses, 2015
Israeli acute paralysis virus (IAPV), a single-stranded RNA virus, has a worldwide distribution and affects honeybees as well as other important pollinators.
Niels Piot, Simon Snoeck, Maarten Vanlede, Guy Smagghe, Ivan Meeus   +4 more
doaj   +1 more source

Transgenic Microalgae Expressing Double-Stranded RNA as Potential Feed Supplements for Controlling White Spot Syndrome in Shrimp Aquaculture

Microorganisms, 2023
Viral infection of farmed fish and shellfish represents a major issue within the aquaculture industry. One potential control strategy involves RNA interference of viral gene expression through the oral delivery of specific double-stranded RNA (dsRNA). In
Patai Charoonnart, Henry Nicholas Taunt, Luyao Yang, Conner Webb, Colin Robinson, Vanvimon Saksmerprome, Saul Purton   +6 more
doaj   +1 more source

Atomic structure reveals the unique capsid organization of a dsRNA virus [PDF]

Proceedings of the National Academy of Sciences, 2009
For most dsRNA viruses, the genome-enclosing capsid comprises 120 copies of a single capsid protein (CP) organized into 60 icosahedrally equivalent dimers, generally identified as 2 nonsymmetricallyinteracting CP molecules with extensive lateral contacts.
Pan, Junhua, Dong, Liping, Lin, Li, Ochoa, Wendy F., Sinkovits, Robert S., Havens, Wendy M., Nibert, Max L., Baker, Timothy S., Ghabrial, Said A., Tao, Yizhi Jane   +9 more
openaire   +4 more sources

Influenza A virus circumvents the innate immune response through the sequestration of double-stranded RNA

Journal of Virology
Double-stranded RNA (dsRNA), which induces an innate immune response against viral infections, is rarely detected in influenza A virus (IAV)-infected cells.
Masahiro Nakano, Sho Miyamoto, Chiho Ohnishi, Chiharu Nogami, Nanami Hirose, Yoko Fujita-Fujiharu, Yukiko Muramoto, Takeshi Noda   +7 more
doaj   +1 more source

siRNA biogenesis and advances in topically applied dsRNA for controlling virus infections in tomato plants

Scientific Reports, 2020
A non-transgenic approach based on RNA interference was employed to induce protection against tomato mosaic virus (ToMV) infection in tomato plants. dsRNA molecules targeting the cp gene of ToMV were topically applied on plants prior to virus inoculation.
Camila M. Rego-Machado, Erich Y. T. Nakasu, João M. F. Silva, Natália Lucinda, Tatsuya Nagata, Alice K. Inoue-Nagata   +5 more
doaj   +1 more source