Results 31 to 40 of about 1,165,839 (240)

Virus and dsRNA-triggered transcriptional responses reveal key components of honey bee antiviral defense

Scientific Reports, 2017
Recent high annual losses of honey bee colonies are associated with many factors, including RNA virus infections. Honey bee antiviral responses include RNA interference and immune pathway activation, but their relative roles in antiviral defense are not ...
Laura M. Brutscher, Katie F. Daughenbaugh, Michelle L. Flenniken   +2 more
doaj   +1 more source

Analysis of Double-Stranded RNA from Microbial Communities Identifies Double-Stranded RNA Virus-like Elements

Cell Reports, 2014
Double-stranded RNA (dsRNA) can function as genetic information and may have served as genomic material before the existence of DNA-based life. By developing a method to purify dsRNA, we have investigated the diversity of dsRNA in microbial populations ...
Carolyn J. Decker, Roy Parker
doaj   +1 more source

Efficient Dicer processing of virus-derived double-stranded RNAs and its modulation by RIG-I-like receptor LGP2.

PLoS Pathogens, 2021
The interferon-regulated antiviral responses are essential for the induction of both innate and adaptive immunity in mammals. Production of virus-derived small-interfering RNAs (vsiRNAs) to restrict virus infection by RNA interference (RNAi) is a ...
Yuqiang Zhang, Yan Xu, Yunpeng Dai, Zhe Li, Jiaxing Wang, Zhi Ye, Yanxin Ren, Hua Wang, Wan-Xiang Li, Jinfeng Lu, Shou-Wei Ding, Yang Li   +11 more
doaj   +1 more source

The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury.

PLoS Pathogens, 2021
The mammalian orthoreovirus double-stranded (ds) RNA-binding protein σ3 is a multifunctional protein that promotes viral protein synthesis and facilitates viral entry and assembly.
Yingying Guo, Meleana M Hinchman, Mercedes Lewandrowski, Shaun T Cross, Danica M Sutherland, Olivia L Welsh, Terence S Dermody, John S L Parker   +7 more
doaj   +1 more source

Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules [PDF]

, 2010
The tospovirus NSs protein was previously shown to suppress the antiviral RNA silencing mechanism in plants. Here the biochemical analysis of NSs proteins from different tospoviruses, using purified NSs or NSs containing cell extracts, is described.
Kormelink, R.J.M., Rik Huismann, Esther Schnettler, Rob Goldbach, Goldbach, R., Marcel Prins, Goldbach, R.W., Kormelink, R., Hemmes, H., Prins, M., Huismann, R., Hans Hemmes, Huisman, R., Hemmes, J.C., Schnettler, E., Richard Kormelink, Prins, M.W.   +16 more
core   +1 more source

Adaptive Response of Saccharomyces Hosts to Totiviridae L-A dsRNA Viruses Is Achieved through Intrinsically Balanced Action of Targeted Transcription Factors

Journal of Fungi, 2022
Totiviridae L-A virus is a widespread yeast dsRNA virus. The persistence of the L-A virus alone appears to be symptomless, but the concomitant presence of a satellite M virus provides a killer trait for the host cell.
Bazilė Ravoitytė, Juliana Lukša, Ralf Erik Wellinger, Saulius Serva, Elena Servienė   +4 more
doaj   +1 more source

Class A scavenger receptor 1 (MSR1) restricts hepatitis C virus replication by mediating toll-like receptor 3 recognition of viral RNAs produced in neighboring cells [PDF]

, 2013
Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health.
McGivern, David R., Fengyu Hu, Daisuke Yamane (206804), David R McGivern, Hu, Fengyu, Hiromichi Dansako (357935), Nobuyuki Kato (235685), Christoph Welsch (22852), Stanley M. Lemon (30543), Daisuke Yamane, Christoph Welsch, Welsch, Christoph, David R. McGivern (415119), Lemon, Stanley M., Kato, Nobuyuki, Fengyu Hu (415120), Dansako, Hiromichi, Stanley M Lemon, Yamane, Daisuke, Nobuyuki Kato, Hiromichi Dansako, Yamane Daisuke, McGivern David R., Welsch Christoph, Hu Fengyu, Dansako Hiromichi, Kato Nobuyuki, Lemon Stanley M.   +27 more
core   +1 more source

Characterization of a Botybirnavirus Conferring Hypovirulence in the Phytopathogenic Fungus Botryosphaeria dothidea

Viruses, 2019
A double-stranded RNA (dsRNA) virus was isolated and characterized from strain EW220 of the phytopathogenic fungus Botryosphaeria dothidea. The full-length cDNAs of the dsRNAs were 6434 bp and 5986 bp in size, respectively.
Lifeng Zhai, Mengmeng Yang, Meixin Zhang, Ni Hong, Guoping Wang   +4 more
doaj   +1 more source

A Novel Partitivirus That Confer Hypovirulence to the Plant Pathogenic Fungus Colletotrichum liriopes

Frontiers in Microbiology, 2021
Here, we report a novel double-stranded RNA virus designated Colletotrichum liriopes partitivirus 1 (ClPV1) from the plant pathogenic fungus C. liriopes.
Jun Zi Zhu, Jun Zi Zhu, Jun Guo, Zhao Hu, Xu Tong Zhang, Xiao Gang Li, Xiao Gang Li, Jie Zhong   +7 more
doaj   +1 more source

A transient homotypic interaction model for the influenza A virus NS1 protein effector domain [PDF]

, 2011
Influenza A virus NS1 protein is a multifunctional virulence factor consisting of an RNA binding domain (RBD), a short linker, an effector domain (ED), and a C-terminal 'tail'. Although poorly understood, NS1 multimerization may autoregulate its actions.
Margaret A Taylor, Richard E. Randall, García-Sastre, A., Hale Benjamin G., Kerry, P.S., Lewis Andrew, Taylor Margaret A., Kerry, Philip S., Andrew Lewis, Kerry Philip S., Hass, C., Benjamin G. Hale, Hale, Benjamin G., Rupert J. Russell, Juan Ayllon, Richard E Randall, Randall Richard E., Hale, B.G., Margaret A. Taylor, Ayllon, Juan, Philip S Kerry, Randall, R.E., Adolfo García-Sastre, Ayllón Barasoain, Juan, Lewis, Andrew, Hass Claudia, Ayllon, J., Rupert J Russell, García Sastre, Adolfo, Taylor, M.A., Lewis, A., García-Sastre Adolfo, Taylor, Margaret A., Hass, Claudia, Ayllon Juan, Russell, R.J., Randall, Richard E., Claudia Hass, Russell, Rupert J., Benjamin G Hale, Russell Rupert J., Philip S. Kerry, Garcia-Sastre, Adolfo, Randall, Richard E.; id_orcid   +43 more
core   +1 more source