Results 51 to 60 of about 1,165,839 (240)

LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA. [PDF]

, 2013
The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that trigger the production of type I ...
Kay S Childs, Richard E. Randall (190211), Randall, RE, Stephen Goodbourn (411674), Goodbourn, Stephen, Kay S. Childs (411673), Richard E. R, Goodbourn, S, Childs, Kay S., Childs Kay S., Richard E Randall, Randall Richard E., Randall, Richard E., Kay S. Childs, Stephen Goodbourn, Childs, KS, Goodbourn Stephen, Randall, Richard E.; id_orcid   +17 more
core   +2 more sources

A putative ATPase mediates RNA transcription and capping in a dsRNA virus [PDF]

eLife, 2015
mRNA transcription in dsRNA viruses is a highly regulated process but the mechanism of this regulation is not known. Here, by nucleoside triphosphatase (NTPase) assay and comparisons of six high-resolution (2.9–3.1 Å) cryo-electron microscopy structures of cytoplasmic polyhedrosis virus with bound ligands, we show that the large sub-domain of the ...
Yu, Xuekui, Jiang, Jiansen, Sun, Jingchen, Zhou, Z Hong   +3 more
openaire   +4 more sources

Nanopore Sequencing of Double-Stranded RNA (dsRNA) for Plant Virus and Viroid Detection

, 2023
Thi file contain results of 24 grapevines leaf samples analyzed using dsRNA-MiSeq (Illumina Miseq) and dsRNAcD sequencing (ONT nanopore), that were used in the following article ''Nanopore Sequencing of Double-Stranded RNA (dsRNA) for Plant Virus and ...
Javaran, Vahid Jalali, Fall, Mamadou Lamine, Poursalavati, Abdonaser   +2 more
core   +1 more source

Binding of influenza A virus NS1 protein to dsRNA in vitro

Journal of General Virology, 1992
The non-structural protein NS1 of influenza A virus exhibits two modes of RNA-binding activity. One is sequence-specific binding to minus-sense virus RNA with either a 5'- or 3'-terminal common sequence as reported previously. The other was identified as binding to dsRNA and this activity did not show sequence specificity.
E, Hatada, R, Fukuda
openaire   +2 more sources

Detection and Molecular Characterization of Novel dsRNA Viruses Related to the Totiviridae Family in Umbelopsis ramanniana

Frontiers in Cellular and Infection Microbiology, 2019
Umbelopsis ramanniana is an oleaginous fungus belonging to the Mucoromycotina subphylum. Our group had previously detected four double-stranded RNA (dsRNA) bands in the U. ramanniana NRRL 1296 strain by gel electrophoresis. Here we describe the molecular
Tünde Kartali, Ildikó Nyilasi, Boglárka Szabó, Sándor Kocsubé, Roland Patai, Tamás F. Polgár, Gábor Nagy, Csaba Vágvölgyi, Tamás Papp, Tamás Papp   +9 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

Angewandte Chemie, EarlyView.
Double‐stranded RNA (dsRNA) plays an important role in the innate immune system, but can be misregulated in disease, leading to inflammation. Despite the importance of this motif, methods for detecting dsRNA remain limited. This work shows that ADAR3 can be repurposed to provide improved detection of dsRNA, which is demonstrated in the context of viral
Weina Cheng, Tyson D. Todd, Alexandria L. Quillin, Harshad Ingle, Angela M. Halstead, Megan T. Baldridge, José B. Sáenz, Jennifer M. Heemstra   +7 more
wiley   +2 more sources

Detection and Characterization of Cucumis melo Cryptic Virus, Cucumis melo Amalgavirus 1, and Melon Necrotic Spot Virus in Cucumis melo

Viruses, 2019
Three RNA viruses—Cucumis melo cryptic virus (CmCV), Cucumis melo amalgavirus 1 (CmAV1), and melon necrotic spot virus (MNSV)—were identified from a melon (Cucumis melo) transcriptome dataset.
Binhui Zhan, Mengji Cao, Kaina Wang, Xifeng Wang, Xueping Zhou   +4 more
doaj   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source