Results 41 to 50 of about 4,194,149 (156)

Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases [PDF]

, 2017
Purpose: The activity of the glymphatic system is impaired in animal models of Alzheimer’s disease (AD). We evaluated the activity of the human glymphatic system in cases of AD with a diffusion-based technique called diffusion tensor image analysis along
Fumihiko Yasuno, Toshiki Nakane, Yasuno, Fumihiko, Shinji Naganawa, Masutani, Yoshitaka, Toshifumi Kishimoto, Matsuoka, Kiwamu, Kishimoto, Toshifumi, Toshiaki Taoka, Hisashi Kawai, Kiwamu Matsuoka, Taoka, Toshiaki, Nakane, Toshiki, Naganawa, Shinji, Kawai, Hisashi, Yoshitaka Masutani, 72735, 72736, 72742, 72740, 72741, 72739, 72737, 72738   +23 more
core   +1 more source

Glymphatic System Dysfunction and its Associated Factors in Wilson's Disease: A DTI–ALPS Study

Brain and Behavior, Volume 16, Issue 10, October 2026.
Glymphatic function, assessed by DTI‐ALPS index, was impaired in neurological Wilson's disease compared with hepatic phenotype and controls. Age, AST, and UWDRS‐I score independently predicted dysfunction, linking neurodegeneration, liver injury, and altered glymphatic activity. ABSTRACT Background Wilson's disease (WD) is a genetic disorder of copper (
Ling Zhu, Tong Wu, Liang‐Jie Zhang, Qin‐yuan Liu, Liang‐liang Zhang, Bin Song, Yu‐long Zhu, Lei Hua, Long Zhang, Bo Li, Quan Sun, Ben‐chun Xue, Yin Xu, Yong‐zhu Han, Yong‐sheng Han   +14 more
wiley   +1 more source

Orientation-Aware Refinement of the DTI-ALPS Index

The diffusion tensor imaging along perivascular spaces (DTI-ALPS) index is a non-invasive marker related to perivascular diffusion, but its reliance on fixed scanner-aligned axes makes it sensitive to head tilt and anatomical variability. We describe a refinement that computes directional diffusivities along subject-specific axes derived from tract ...
Hwang, Scott, Jones, Gavin, Mubin, Numa, Quillen, Jack, Kanekar, Sangam   +4 more
openaire   +1 more source

Evaluation of the DTI-ALPS Index as a Biomarker of the Glymphatic System at 1.5T

The Open Neuroimaging Journal
Introduction The glymphatic system is a waste clearance pathway within the brain that relies on the flow of cerebrospinal fluid facilitated by astrocytes. It has been proposed that this glymphatic system can be observed using Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS).
Irene Marín, Francisco Torres, Rodrigo Riveros, Bárbara Oliva, Joanna Vega, Carolina Saavedra, Sebastián Rojas, Matías González, Carlos Bennett, Pablo Cox, Stéren Chabert   +10 more
openaire   +1 more source

Increased glymphatic system activity in migraine chronification by diffusion tensor image analysis along the perivascular space

The Journal of Headache and Pain, 2023
Background Preliminary evidence suggests that several headache disorders may be associated with glymphatic dysfunction. However, no studies have been conducted to examine the glymphatic activity in migraine chronification.
Xue Zhang, Wei Wang, Xiaoyan Bai, Xueyan Zhang, Ziyu Yuan, Bingjie Jiao, Yingkui Zhang, Zhiye Li, Peng Zhang, Hefei Tang, Yaqing Zhang, Xueying Yu, Ruiliang Bai, Yonggang Wang, Binbin Sui   +14 more
doaj   +1 more source

Association of Glymphatic Imaging Markers With Clinical Outcomes and Cerebral Small Vessel Disease Burden After Intracerebral Hemorrhage

Brain and Behavior, Volume 16, Issue 10, October 2026.
In patients with intracerebral hemorrhage, higher free water fraction in contralateral white matter was associated with lower odds of functional independence and greater WMH burden. These associations did not remain statistically significant after FDR correction, and the FW–outcome association was nonsignificant after adjustment for WMH burden ...
Xiao Hu, Zuoqiao Li, Zijie Wang, Yingmei Zhang, Mengqiu Zhang, Sijia Liu, Fan Chen, Jianshuo Shao, Longsheng Wang, Qi Li   +9 more
wiley   +1 more source

Magnetic Resonance Imaging in Cerebral Small Vessel Disease‐Related Depression: From Visual Scoring to Artificial Intelligence

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Starting with MRI data acquisition, it presents the core steps and outputs of visual scoring, traditional machine learning, and deep learning along three evolving paths, and integrates them into the clinical application direction, illustrating the technological evolution from qualitative description to precise prediction.
Chaofang Lei, Jiaxu Chen, Yilong Wang
wiley   +1 more source

Altered Perivascular Diffusivity in Glioblastoma: Integrating DTI-ALPS Index with Radio-Pathomic and Histopathologic Correlates

Journal of Neuro-Oncology
Abstract Purpose: Glioblastoma is an aggressive primary brain tumor that often exhibits perivascular invasion. This behavior may directly interfere with glymphatic flow, hindering perivascular drainage routes. This study aims to assess glymphatic dysfunction in glioblastoma by evaluating the DTI-ALPS index, an MRI ...
Nath, Biprojit, Bobholz, Samuel A., Kim, Daniel C., Lowman, Allison K., Duenweg, Savannah R., Winiarz, Aleksandra, Chao, Benjamin, Kyereme, Fitzgerald, Barrett, Michael, Reecher, Hope M., Connelly, Jennifer, Mrachek, E. Kelly S., Jacobsohn, Jamie, Krucoff, Max O., Tanhehco, Elaine, Agarwal, Mohit, Destiche, Daniel, Banerjee, Anjishnu, LaViolette, Peter S.   +18 more
openaire   +4 more sources

Cerebral Artery Stenosis, Glymphatic Dysfunction, and Cognitive Trajectories: A Longitudinal Cohort Study of Community‐Dwelling Older Adults

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
DTI‐ALPS and FW‐WM significantly mediated the association between stenosis burden and baseline MMSE. Participants with both stenosis and impaired glymphatic function showed the most rapid MMSE decline and a higher risk of CDR‐SB worsening than those with stenosis but preserved glymphatic function or those without stenosis.
Weizhuang Yuan, Xingyang Niu, Linfang Lan, Xinran Chen   +3 more
wiley   +1 more source

Table_1_Dysfunction of the glymphatic system in childhood absence epilepsy.DOCX

, 2023
ObjectiveThis study aimed to evaluate the glymphatic system in childhood absence epilepsy (CAE) using diffusion tensor image analysis along the paravascular space (DTI-ALPS) index.
Wenwei Zou (15458018), Wanqing Pu (17600928), Xiaoyu Chen (298872), Mengdi Qiu (6368510), Yingchao Ge (17600934), Shanzhen Wei (17600931), Wenchao Qiu (6901748)   +6 more
core   +1 more source