Results 31 to 40 of about 4,194,149 (156)

Decrease of excessive daytime sleepiness after shunt treatment for normal pressure hydrocephalus

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleepiness and apathy are often reported in patients with normal pressure hydrocephalus. However, research on outcomes after shunt surgery has mainly focused on the classical triad symptoms, that is, gait, cognition, and bladder dysfunction. This study aimed to describe the effects of shunt treatment on excessive daytime sleepiness and whether ...
Simon Lidén, Anna Lindam, Dan Farahmand, Anne‐Marie Landtblom, Katarina Laurell   +4 more
wiley   +1 more source

Multimodal Characterization of Glymphatic‐Related Magnetic Resonance Imaging Markers in Huntington's Disease: A Multi‐Cohort Retrospective Study

Annals of Neurology, Volume 100, Issue 5, Page 1055-1067, November 2026.
Objective To characterize magnetic resonance imaging (MRI)‐based glymphatic surrogates in Huntington's disease (HD) using MRI measures of perivascular diffusivity and structural perivascular alterations across multiple large cohorts. Methods We analyzed 2,731 MRI sessions from 880 participants across 3 large retrospective HD cohorts.
Alexia Solomon, Zexi Wang, Francesco Sanvito, Zheng Zhou, Adys Mendizabal, Jingwen Yao   +5 more
wiley   +1 more source

Glymphatic system dysfunction in children with autism spectrum disorder as evidenced by the diffusion tensor imaging along perivascular spaces index

Frontiers in Psychiatry
IntroductionThis study aims to evaluate glymphatic system function in autism spectrum disorder (ASD) by employing diffusion tensor imaging along perivascular spaces (DTI-ALPS), and investigate its relationship with visual-motor integration (VMI) function.
Shengnan Zhao, Manxue Zhang, Tingting Luo, Lei Li, Yuchu Jiang, Mingjing Situ, Yi Huang, Yi Huang, Yi Huang   +8 more
doaj   +1 more source

Brain Clearance of Contrast Agent in Intravenous DCE‐MRI Is Measurable and Cannot Be Explained by Clearance Across the BBB Alone

Magnetic Resonance in Medicine, Volume 96, Issue 5, Page 2309-2320, November 2026.
ABSTRACT Purpose To determine the feasibility of measuring brain clearance of gadolinium contrast agent using standard intravenous DCE‐MRI acquisitions and evaluate the contribution of blood–brain barrier (BBB) and non‐BBB clearance routes. Methods Uptake and extended Tofts models were fit to DCE‐MRI data from people with Parkinson's disease, post ...
Martin Kozár, Ioana‐Emilia Mosneag, Sarah Al‐Bachari, Igor Chernyavsky, Geoff J. M. Parker, Hervé Boutin, Laura M. Parkes, Ingo Schiessl, Ben R. Dickie   +8 more
wiley   +1 more source

DTI-ALPS index as a predictor of glymphatic system dysfunction in cerebral infarction

American Journal of Translational Research
To evaluate glymphatic system (GS) dysfunction in patients with cerebral infarction using diffusion tensor imaging - along the perivascular space (DTI-ALPS), and to investigate factors associated with glymphatic function impairment following stroke.A retrospective study was conducted on 82 patients diagnosed with cerebral infarction at Zhujiang ...
Bomiao, Lin, Yuh Yang, Leong, Mazlyfarina, Mohamad   +2 more
openaire   +2 more sources

Glymphatic system dysfunction associated with cognitive impairment in chronic tinnitus patients

Frontiers in Neuroscience
BackgroundThe glymphatic system has been regarded as a pivotal factor in the pathogenesis of neurodegenerative diseases. Given the heightened risk of cognitive impairment in chronic tinnitus patients, the possible alterations of the glymphatic system in ...
Yinjuan Du, Zhichun Huang, Yuanqing Wu, Yuan Xue, Zigang Che   +4 more
doaj   +1 more source

Vascular drivers of cerebrospinal fluid movement and enlarged perivascular spaces

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Perivascular spaces (PVSs) facilitate cerebrospinal fluid flow and waste clearance, which are critical for maintaining brain homeostasis. Enlarged PVSs (ePVSs) are an emerging marker of cerebral small vessel disease and are implicated in protein accumulation, neurodegeneration, and cognitive decline.
James D. LeFevre, Yukti Vyas, Angela L. Jefferson   +2 more
wiley   +1 more source

Additional file 1 of Increased glymphatic system activity in migraine chronification by diffusion tensor image analysis along the perivascular space

, 2023
Additional file 1: Figure S1. Correlations between headache intensity and DTI-ALPS index both in the left hemisphere (a) and right hemisphere (b) before Bonferroni correction (p < 0.0025, statistical significance).
Xueyan Zhang (277449), Hefei Tang (8083562), Ruiliang Bai (4480165), Bingjie Jiao (15774554), Yingkui Zhang (13109976), Xueying Yu (605947), Ziyu Yuan (122263), Binbin Sui (8624580), Xue Zhang (166886), Peng Zhang (2071), Wei Wang (17594), Yaqing Zhang (296099), Zhiye Li (13109979), Xiaoyan Bai (554943), Yonggang Wang (115253)   +14 more
core   +1 more source

Reconsideration of the DTI-ALPS index as a glymphatic surrogate: disease-specific findings in small vessel disease due to cerebral amyloid angiopathy or arteriolosclerosis

Frontiers in Aging Neuroscience
ObjectivesTo explore the disease-specific performance of diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index in cerebral amyloid angiopathy (CAA) and arteriolosclerosis CSVD (aCSVD).MethodsWe retrospectively enrolled probable ...
Yaping Zhou, Xingqi Pan, Ziyi Xia, Yuhui Sha, Gan Sun, Fei Han, Ming Yao, Lixin Zhou, Liyun Tu, Feng Feng, Joanna M. Wardlaw, Yi-Cheng Zhu, Jun Ni   +12 more
doaj   +1 more source

MRI‐derived glymphatic‐related composite captures brain and cognitive vulnerability associated with cardiovascular risk in older adults

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION We evaluated a multimodal magnetic resonance imaging (MRI)‐derived glymphatic‐related composite and examined its associations with cardiovascular risk, brain structural integrity, and cognition in older adults. METHODS Ninety‐two participants were included in the baseline analyses and 68 in the 6‐month reassessment analyses ...
Zhan Wang, Guojun Lin, Fang Fang, Jing Yu   +3 more
wiley   +1 more source