Results 51 to 60 of about 4,194,149 (156)

Differential glymphatic dysfunction and memory correlation in temporal lobe epilepsy subtypes

Epilepsia Open
Objective This study aims to evaluate the glymphatic system (GS) in different temporal lobe epilepsy (TLE) subtypes using diffusion tensor imaging analysis along the perivascular space (DTI‐ALPS) and to explore its correlation with clinical factors and ...
Ruotong Chen, Hong Li, Pu Miao, Hongyi Ye, Xiao Chen, Yuyu Yang, Jinqi Zhou, Yihe Chen, Yi Ge, Chenmin He, Xiaotong Shao, Zijian Wang, Yuting Gong, Cong Chen, Shan Wang, Lingli Hu, Lingqi Ye, Yao Ding, Shuang Wang, Linglin Yang   +19 more
doaj   +1 more source

Non-invasive assessment of glymphatic dysfunction in middle cerebral artery stenosis based on DTI-ALPS and ro-ALPS

Frontiers in Neurology
BackgroundMiddle cerebral artery stenosis (MCA-S) impairs cerebral perfusion and vascular pulsatility, potentially disrupting cerebrospinal fluid dynamics.
Yidi Zhu, Luoyu Wang, Liqing Zhang, Xue Tang, Maoling Liu, Qingqing Wen, Darong Zhu, Han Zhang, Xiufang Xu, Zhongxiang Ding   +9 more
doaj   +1 more source

DTI‐ALPS Primarily Reflects White Matter Diffusion Dispersion and Microstructural Heterogeneity in Neurodegeneration: Insights From Multi‐Modal MRI

Human Brain Mapping, Volume 47, Issue 14, October 1, 2026.
In a 100‐patient memory‐clinic cohort, DTI‐ALPS was evaluated along with diffusion and microstructural metrics. DTI‐ALPS correlated strongly with mode of anisotropy and orientation dispersion index, and moderately with T1/FLAIR ratio and diamagnetic susceptibility, indicating that DTI‐ALPS mainly reflects white‐matter diffusion complexity rather than ...
Luca Sacchi, Giovanni Farruggio, Giorgio Bocca, Tiziana Carandini, Milena De Riz, Laura Ghezzi, Manuela Pintus, Anna Pietroboni, Giacomo Boffa, Elisa Scola, Fabio Triulzi, Marco Bozzali, Daniela Galimberti, Mara Cercignani, Andrea Arighi   +14 more
wiley   +1 more source

Diffusion along perivascular spaces as a marker for Glymphatic system impairment in spinocerebellar Ataxia type 3

Neurobiology of Disease
Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder characterized by the accumulation of polyglutamylated ATXN3 protein within neurons, which can potentially compromise the integrity of the brain's glymphatic system.
Xiao-Yue Xia, Zi-Qiang Huang, Hao-Hang Lin, Zhen-Yi Liu, Lin Zhang, Meng-Cheng Li, Yu-Qin Tu, Na-Ping Chen, Jun Ni, Qun-Lin Chen, Jian-Ping Hu, Shi-Rui Gan, Xin-Yuan Chen   +12 more
doaj   +1 more source

Data_Sheet_1_Glymphatic Dysfunction in Patients With End-Stage Renal Disease.PDF

, 2022
BackgroundWe aimed to compare glymphatic dysfunction between patients with end-stage renal disease (ESRD) and healthy controls and analyze the correlation between the glymphatic function and clinical characteristics using the diffusion tensor image ...
Byeong Cheol Yoo (11994914), Chang Min Heo (11994905), Kang Min Park (11340423), Sihyung Park (11994908), Yoo Jin Lee (489567), Yang Wook Kim (11994911), Bong Soo Park (8938457), Dong Ah Lee (11340420), Won Ho Lee (4801527)   +8 more
core   +1 more source

DTI‐ALPS as a Biomarker of Small Vessel Disease Progression and Amyloid‐β in Normal Aging: A 3‐Year Longitudinal Study

Human Brain Mapping, Volume 47, Issue 14, October 1, 2026.
A higher DTI‐derived ALPS index relates cross‐sectionally to both quantitative and visual measures of SVD and is associated with short‐term amyloid‐β accumulation in cognitively normal older adults. Also, greater amyloid burden and choroid plexus volume are associated with a more rapid deterioration in global cognition and processing speed.
Narges Azizi, Hoda Borooghani, Iman Kiani, Zeinab Gharaylou, Dina Seyedi, Kavous Firouznia, Shahriar Kolahi   +6 more
wiley   +1 more source

Multimodal neuroimaging of brain microstructure and hippocampal morphology alterations in type 2 diabetes mellitus

Scientific Reports
Type 2 diabetes affects the central nervous system, yet the role of glymphatic dysfunction remains unclear. This study investigated alterations in the DTI-ALPS index in T2DM patients and its associations with cognitive function, white matter integrity ...
Mengyuan Li, Lin Yao, Zhen Zhong, Haipeng Huang, Yanglan Li, Haizhu Zheng, Hongfeng Wang   +6 more
doaj   +1 more source

Association of glymphatic system dysfunction with cognitive impairment in temporal lobe epilepsy

Frontiers in Aging Neuroscience
ObjectivesTo explore the relationship between glymphatic dysfunction and cognitive impairment in unilateral temporal lobe epilepsy (TLE).MethodsThis study retrospectively included 38 patients with unilateral TLE and 26 age- and gender-matched healthy ...
Jiajia Wang, Xiaona Xia, Bin Zhang, Xiaotian Ma, Feng Shi, Ying Wei, Ling Li, Xiangshui Meng   +7 more
doaj   +1 more source

Shared genetic architecture between DTI‐ALPS traits and neurodegenerative diseases

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Diffusion tensor image analysis along the perivascular space (DTI‐ALPS) index is associated with neurodegenerative diseases (NDDs), but its shared genetic basis with NDDs remains unclear. METHODS By integrating genome‐wide association datasets for three DTI‐ALPS traits and seven NDDs, we quantified polygenic overlap using MiXeR ...
Hong Zhou, Jialin Deng, Qian Wu, Yule Zeng, Tianyao Wang, Jiayi Wu, Xiaomei Duan, Beisha Tang, Xinhua Wei, Lu He, Feng Liu   +10 more
wiley   +1 more source

Glymphopathy and Reduced Processing Speed in Community-Dwelling Adults with Silent Cerebral Small Vessel Disease: A DTI-ALPS Study

Background/Objectives: Cerebral small vessel disease (CSVD) often manifests as enlarged perivascular spaces (ePVS), which are linked to reduced processing speed even in asymptomatic individuals.
Muhammad Danial Che Ramli, Che Mohd Nasril Che Mohd Nassir, Zaw Myo Hein, Muhammad Faqhrul Fahmy Arbain, Usman Jaffer   +4 more
core   +1 more source