Results 61 to 70 of about 750,537 (293)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Substance misuse assessment in mental health services: the importance of professional curiosity [PDF]

, 2017
Co-morbidity of mental health and substance misuse problems (or "Dual Diagnosis") is highly prevalent in mental health and drug treatment services. The parallel approach, where the two conditions are treated at the same time in separate services, is the ...
Milani, Raffaella Margherita, University of West London   +1 more
core  

The diagnostic accuracy of two human epididymis protein 4 (HE4) testing systems in combination with CA125 in the differential diagnosis of ovarian masses [PDF]

, 2011
Background: Cancer antigen 125 (CA125) is the best known single tumor marker for ovarian cancer (OC). We investigated whether the additional information of the human epididymis protein 4 (HE4) improves diagnostic accuracy.
Burges, Alexander, Fuerst, Sophie, Hertlein, Linda, Hofmann, Karin, Kirschenhofer, Angela, Krocker, Katja, Lenhard, Miriam, Mayr, Doris, Nagel, Dorothea, Stieber, Petra   +9 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A multisite randomized controlled trial of Seeking Safety vs. Relapse Prevention Training for women with co-occurring posttraumatic stress disorder and substance use disorders

European Journal of Psychotraumatology, 2019
Background: Co-occurring posttraumatic stress disorder (PTSD) and substance use disorders (SUD) are associated with a more severe course and worse outcome than either disorder alone. In Europe, few treatments have been evaluated for PTSD and SUD. Seeking
Ingo Schäfer, Annett Lotzin, Philipp Hiller, Susanne Sehner, Martin Driessen, Thomas Hillemacher, Martin Schäfer, Norbert Scherbaum, Barbara Schneider, Johanna Grundmann   +9 more
doaj   +1 more source

Group Motivational Interviewing as a Psychotherapeutic Intervention for Dual Diagnosis Patients Living with a Psychotic Disorder: Critique of the Literature [PDF]

, 2012
Studies indicate that 50% of individuals living with a psychotic disorder also meet Diagnostic and Statistical Manual IV Text Revision (DSM-IV-TR) criteria for substance abuse disorder during their lifetime (Green, Drake, Brunette, & Noordsy, 2007 ...
Stauder, Alexander D
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The relationship between personality dimensions and addiction type in women addicted to alcohol and opioids

Scientific Reports
Personality traits significantly influence the development, persistence, and treatment outcomes of substance use disorders. Despite increasing addiction rates among women, sex-specific research remains limited.
Diana Raketić, Nikola Lalović, Jasmina Barišić, Ivan Ćelić, Srdjan Milovanović   +4 more
doaj   +1 more source

Childhood maltreatment trauma: a comparison between patients in treatment for substance use disorders and patients in mental health treatment

European Journal of Psychotraumatology, 2018
Background: While previous research has found strong associations between childhood maltreatment trauma and substance use disorders (SUDs), the role of possible moderating effects of gender and mediating effects of psychopathology and SUD is unclear ...
Ingvild S. Rasmussen, Kjersti Arefjord, Dagfinn Winje, Anders Dovran   +3 more
doaj   +1 more source

Treating Dual Diagnosis Patients: Challenges and Opportunities [PDF]

, 2011
The use and abuse of drugs and alcohol have recently gained greater attention both from the public and the medical profession. Despite increasing cognizance of its unfortunate consequences, substance use has become a more pervasive element of ...
Howland, M.D., Robert H.
core   +1 more source