Results 111 to 120 of about 17,522 (280)

Dynactin 3D Structure: Implications for Assembly and Dynein Binding [PDF]

Journal of Molecular Biology, 2014
The multisubunit protein complex, dynactin, is an essential component of the cytoplasmic dynein motor. High-resolution structural work on dynactin and the dynein/dynactin supercomplex has been limited to small subunits and recombinant fragments that do not report fully on either ≈1MDa assembly.
Hiroshi, Imai, Akihiro, Narita, Yuichiro, Maéda, Trina A, Schroer   +3 more
openaire   +2 more sources

The Roles of Plant MicroRNAs in Defence Against Pathogens

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
miRNAs modulate plant immunity against various pathogens, including fungi, bacteria, viruses, nematodes and oomycetes, by targeting pathogen effectors and modulating hormonal signalling. ABSTRACT MicroRNAs (miRNAs) are a class of noncoding RNAs that play important roles in regulating gene expression.
Abdou Mahaman Mahamadou, Assane Hamidou Abdoulaye, Yuhua Chen, Linling Zheng, Mayamiko Masangano, Attiogbe Kekely Bruno, Yinhua Chen   +6 more
wiley   +1 more source

Identification of Rab41/6d effectors provides an explanation for the differential effects of Rab41/6d and Rab6a/a' on Golgi organization

Frontiers in Cell and Developmental Biology, 2016
Unexpectedly, members of the Rab VI subfamily exhibit considerable variation in their effects on Golgi organization and trafficking. By fluorescence microscopy, neither depletion nor overexpression of the GDP-locked form of Rab6a/a’, the first trans ...
Shijie eLiu, Waqar eMajeed, Tetyana eKudlyk, Vladimir eLupashin, Brian eStorrie   +4 more
doaj   +1 more source

Diet and cell size both affect queen-worker differentiation through DNA methylation in honey bees (Apis mellifera, Apidae). [PDF]

PLoS ONE, 2011
Young larvae of the honey bee (Apis mellifera) are totipotent; they can become either queens (reproductives) or workers (largely sterile helpers). DNA methylation has been shown to play an important role in this differentiation. In this study, we examine
Yuan Yuan Shi, Zachary Y Huang, Zhi Jiang Zeng, Zi Long Wang, Xiao Bo Wu, Wei Yu Yan   +5 more
doaj   +1 more source

So far, yet so close: α-Catenin dimers help migrating cells get together [PDF]

, 2017
Epithelial cells in tissues use their actin cytoskeletons to stick together, whereas unattached cells make active plasma membrane protrusions to migrate. In this issue, Wood et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201612006) show that the
Benjamin, Braga, Chinthalapudi, Drees, Edwards, Hansen, Klezovitch, Laura Machesky, Lien, Shewan, Vania M.M. Braga, Vasioukhin, Wood   +12 more
core   +2 more sources

Role of dynein–dynactin complex, kinesins, motor adaptors, and their phosphorylation in dendritogenesis

Journal of Neurochemistry, 2020
One of the characteristic features of different classes of neurons that is vital for their proper functioning within neuronal networks is the shape of their dendritic arbors.
A. Tempes, J. Węsławski, A. Brzozowska, J. Jaworski   +3 more
semanticscholar   +1 more source

Dynactin drives dynein without microtubule binding [PDF]

The Journal of Cell Biology, 2007
Dynactin might bind to and organize microtubules. But it doesn't need to bind microtubules to jump-start dynein motoring, Kim et al. report on page 641. Figure 1 Organelle cargo distribution is similar in wild-type cells (left) and cells expressing nonmicrotubule-binding dynactin (right), indicating that transport remains intact ...
openaire   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, Volume 9, Issue 12, December 2025.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M

Nature Communications, 2023
The activity of dynein is regulated by a number of adaptors that mediate its interaction with dynactin, effectively activating the motor complex while also connecting it to different cargos.
Núria Gallisà-Suñé, Paula Sànchez-Fernàndez-de-Landa, Fabian Zimmermann, Marina Serna, Laura Regué, Joel Paz, Oscar Llorca, Jens Lüders, Joan Roig   +8 more
doaj   +1 more source

A microscopy-based screen employing multiplex genome sequencing identifies cargo-specific requirements for dynein velocity [PDF]

, 2014
The timely delivery of membranous organelles and macromolecules to specific locations within the majority of eukaryotic cells depends on microtubule-based transport.
Abenza JF, Anthony J. Roberts, Bailleul B, Barbour L, Cho C, Eckley DM, Egan MJ, Egan MJ, Erzberger JP, Fernandez-Abalos JM, Galagan J, Gero Steinberg, Gibson DG, Hammer JA, Hendricks AG, Huang J, Ikenaga M, Imamula K, Kaeling Tan, Kon T, Laan L, Lee SB, Lefrancois P, Lenz JH, Li H, Li H, Ligon LA, Malone CJ, Mark Chonofsky, Martin J. Egan, McKenna A, Meyer M, Morris NR, Murakami K, Nayak T, Orr-Weaver TL, Perlson E, Qiu W, Reck-Peterson SL, Requena N, Samara L. Reck-Peterson, Schafer DA, Schmidt H, Seidel C, Shaner NC, Sivagurunathan S, Subach OM, Szewczyk E, Todd RB, Todd RB, Vogel SK, Wortman JR, Xiang X, Xiang X, Zhang J, Zhang J   +55 more
core   +3 more sources