Results 111 to 120 of about 9,677 (245)

Prognostic Value of Dynactin mRNA Expression in Cutaneous Melanoma [PDF]

Medical Science Monitor, 2018
BACKGROUND Dynactin (DCTN) is a multi-subunit protein encoded by DCTN genes for 6 subunits. In different diseases the DCTN genes may have different roles; therefore, we investigated the prognostic potential of DCTN mRNA expression in cutaneous melanoma (CM).
Qiaoqi Wang, Xiangkun Wang, Dong Li, Xiwen Liao, Shijun Wang, Fuqiang Pan, Qian Liang   +6 more
openaire   +2 more sources

3D Cell Culture on Hierarchical Porous Soft Aerogel Structures Printed by DIW Process from Dual Network Gel Ink

Advanced Materials Technologies, Volume 10, Issue 5, March 4, 2025.
A 3D biocompatible gel is prepared by crosslinking silica and PVA/TMA, forming a dual flexible network with hierarchical porous structures. The MDCK cells are seeded and spatially distributed within the 3D biocompatible scaffold, exhibiting uniform growth and proliferation, maintaining viability for over 35 days.
Javier Lopez Navas, Chin Yan Suen, Zhang Liu, Deo Charis Mostrales, King Lun Yeung   +4 more
wiley   +1 more source

Domain organization and conformational change of dynactin p150 [PDF]

, 2018
AbstractDynactin is a principal regulator of the minus-end directed microtubule motor dynein. The sidearm of dynactin is essential for binding to microtubules and regulation of dynein activity. Although our understanding of the structure of the dynactin backbone (Arp1 rod) has greatly improved recently, structural details of the sidearm part remain ...
Saito, Kei, Murayama, Takashi, Hata, Tomone, Kobayashi, Takuya, Shibata, Keitaro, Kazuno, Saiko, Fujimura, Tsutomu, Sakurai, Takashi, Toyoshima, Yoko Y.   +8 more
openaire   +2 more sources

Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome

EBioMedicine, 2017
Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150Glued, is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra.
Yuka Hosaka, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Changxu Cui, Taku Arano, Yuzuru Imai, Nobutaka Hattori   +6 more
doaj   +1 more source

Conformational diversity of dynactin sidearm and domain organization of its subunit p150

Molecular Biology of the Cell, 2020
Dynactin is a principal regulator of the minus-end directed microtubule motor dynein. The sidearm of dynactin is essential for binding to microtubules and regulation of dynein activity. Although our understanding of the structure of the dynactin backbone
Kei Saito, T. Murayama, Tomone Hata, Takuya Kobayashi, Keitaro Shibata, S. Kazuno, T. Fujimura, Takashi Sakurai, Y. Toyoshima   +8 more
semanticscholar   +1 more source

Semantic variant primary progressive aphasia with ANXA11 p.D40G

Alzheimer's &Dementia, Volume 21, Issue 3, March 2025.
Abstract INTRODUCTION Pathogenic variants of annexin A11 (ANXA11) have been identified in patients with amyotrophic lateral sclerosis (ALS) with or without frontotemporal dementia (FTD). We explored ANXA11 pathogenic variants in a Korean FTD cohort to investigate the prevalence and the role of ANXA11 variation in FTD.
Sun Min Lee, Soo Jin Yoon, Kyung Won Park, Ahro Kim, Hee Jin Kim, Na‐Yeon Jung, Hyemin Jang, William W. Seeley, Young‐Eun Kim, So Young Moon, Eun‐Joo Kim, the Longitudinal study of Early onset dementia And Family members (LEAF) investigators   +11 more
wiley   +1 more source

The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway

Experimental and Molecular Medicine, 2020
Osteoclasts (OCs), cells specialized for bone resorption, are generated from monocyte/macrophage precursors by a differentiation process governed by RANKL.
Yong Deok Lee, Bongjun Kim, Suhan Jung, Haemin Kim, Min Kyung Kim, Jun-Oh Kwon, Min-Kyoung Song, Z. Lee, Hong-Hee Kim   +8 more
semanticscholar   +1 more source

Locus coeruleus vulnerability to tau hyperphosphorylation in a rat model

Aging Cell, Volume 24, Issue 3, March 2025.
Hyperphosphorylated tau (ptau) leads to calcium overload via LTCC Cav1.2 channels (1), mitochondrial complex I deficit (2), increased mitochondrial fusion (3), which can be associated with reactive oxygen species (ROS) production. Ptau also impedes anterograde transport of distinct cargoes including mitochondria.
Tamunotonye Omoluabi, Zia Hasan, Jessie E. Piche, Abeni R. S. Flynn, Jules J. E. Doré, Susan G. Walling, Andrew C. W. Weeks, Touati Benoukraf, Qi Yuan   +8 more
wiley   +1 more source

The role of microtubules and the dynein/dynactin motor complex of host cells in the biogenesis of the Coxiella burnetii-containing vacuole.

PLoS ONE, 2019
Microtubules (Mts) are dynamic cytoskeleton structures that play a key role in vesicular transport. The Mts-mediated transport depends on motor proteins named kinesins and the dynein/dynactin motor complex.
Rodolfo M Ortiz Flores, Jesús S Distel, Milton O Aguilera, Walter Berón   +3 more
doaj   +1 more source

RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

eLife, 2018
Polarised mRNA transport is a prevalent mechanism for spatial control of protein synthesis. However, the composition of transported ribonucleoprotein particles (RNPs) and the regulation of their movement are poorly understood.
Mark A McClintock, Carly I Dix, Christopher M Johnson, Stephen H McLaughlin, Rory J Maizels, Ha Thi Hoang, Simon L Bullock   +6 more
doaj   +1 more source